目的探讨广州花都地区和贵州黔西地区急性胰腺炎(AP)的发病病因及临床特征。方法回顾性分析2008年1月至2018年12月广州市花都区人民医院及贵州省黔西县人民医院收治的1 832例AP患者临床资料,对不同地区AP占同期总住院人数的比例、入院时...目的探讨广州花都地区和贵州黔西地区急性胰腺炎(AP)的发病病因及临床特征。方法回顾性分析2008年1月至2018年12月广州市花都区人民医院及贵州省黔西县人民医院收治的1 832例AP患者临床资料,对不同地区AP占同期总住院人数的比例、入院时BISAP评分、急性生理功能和慢性健康状况评分II(APACHE-II)、Ranson评分、病因分型、各种并发症及病死率进行统计学对比分析。结果广州花都地区(沿海地区)AP占同期总住院人数的0.21%,贵州黔西地区(山区地区)AP占同期总住院人数的0.47%,沿海地区胆源性胰腺炎占比较山区地区高(57.3% vs 35.8%,P<0.05),而高脂血症性胰腺炎及酒精性胰腺炎山区地区占比较沿海地区高(28.0% vs 19.6%,P<0.05);在基本相同的生长抑素使用率及住院费用情况下,山区地区急性胰腺炎并发器官衰竭及病死率较沿海地区高(7.8% vs 2.6%,P<0.05)。结论山区地区AP发病率较沿海地区高,两地AP病因均以胆源性为主;病因占比方面,沿海地区胆源性AP占比较山区地区高,而酒精性和高脂血症性AP则后者高于前者;山区地区AP病情普遍较沿海地区严重,器官衰竭发生率及病死率较沿海地区高。展开更多
Objective To study the antineoplastic effect of the calcium channel blocker verapamil and 5-fluorouracil intraperitoneal chemotherapy onhepatocarcinoma-bearing rats, and examine the action between calcium channel bloc...Objective To study the antineoplastic effect of the calcium channel blocker verapamil and 5-fluorouracil intraperitoneal chemotherapy onhepatocarcinoma-bearing rats, and examine the action between calcium channel blockers and cytotoxic drugs.Methods We adopted the method of subcapsular implantation of carcinoma tissues of walker-256 in the left liver lobe as a model of livercarcinoma-bearing rats. All experimental animals were divided into four groups. On the sixth day post implantation, in group A (controlgroup) 6 ml of saline was injected intraperitoneally once a day for 3 days. In group B (single chemotherapy group) 6 ml of 5-Fu 75 mg/kg was injected intraperitoneally once a day for 3 days. In group C (combination of treatment group) both 5-Fu (75 mg/kg) and verapamil(25 mg/kg) were administered simultaneously as in A and B. In group D (simple verapamil group) only 6 ml of verapamil (25 mg/kg)was administered as above.Results Compared with groups A, B and D, The volume of cancer and the contents of liver cancer DNA and protein were significantlyreduced. The rates of inhibiting cancer (89.9% in group C and 35.4% in group B) were significantly increased in group C. Group C hadsignificantly long survival time compared to groups A, B and D ( P < 0.05) . By light microscopy, a number of focal necroses were foundin cancer tissue in group C.Conclusion Calcium channel blockers can enhance the antineoplastic effect of 5-Fu intraperitoneal chemotherapy to liver cancer ; Theuse of verapamil can not increase the toxicity of 5-Fu.展开更多
文摘目的探讨广州花都地区和贵州黔西地区急性胰腺炎(AP)的发病病因及临床特征。方法回顾性分析2008年1月至2018年12月广州市花都区人民医院及贵州省黔西县人民医院收治的1 832例AP患者临床资料,对不同地区AP占同期总住院人数的比例、入院时BISAP评分、急性生理功能和慢性健康状况评分II(APACHE-II)、Ranson评分、病因分型、各种并发症及病死率进行统计学对比分析。结果广州花都地区(沿海地区)AP占同期总住院人数的0.21%,贵州黔西地区(山区地区)AP占同期总住院人数的0.47%,沿海地区胆源性胰腺炎占比较山区地区高(57.3% vs 35.8%,P<0.05),而高脂血症性胰腺炎及酒精性胰腺炎山区地区占比较沿海地区高(28.0% vs 19.6%,P<0.05);在基本相同的生长抑素使用率及住院费用情况下,山区地区急性胰腺炎并发器官衰竭及病死率较沿海地区高(7.8% vs 2.6%,P<0.05)。结论山区地区AP发病率较沿海地区高,两地AP病因均以胆源性为主;病因占比方面,沿海地区胆源性AP占比较山区地区高,而酒精性和高脂血症性AP则后者高于前者;山区地区AP病情普遍较沿海地区严重,器官衰竭发生率及病死率较沿海地区高。
文摘Objective To study the antineoplastic effect of the calcium channel blocker verapamil and 5-fluorouracil intraperitoneal chemotherapy onhepatocarcinoma-bearing rats, and examine the action between calcium channel blockers and cytotoxic drugs.Methods We adopted the method of subcapsular implantation of carcinoma tissues of walker-256 in the left liver lobe as a model of livercarcinoma-bearing rats. All experimental animals were divided into four groups. On the sixth day post implantation, in group A (controlgroup) 6 ml of saline was injected intraperitoneally once a day for 3 days. In group B (single chemotherapy group) 6 ml of 5-Fu 75 mg/kg was injected intraperitoneally once a day for 3 days. In group C (combination of treatment group) both 5-Fu (75 mg/kg) and verapamil(25 mg/kg) were administered simultaneously as in A and B. In group D (simple verapamil group) only 6 ml of verapamil (25 mg/kg)was administered as above.Results Compared with groups A, B and D, The volume of cancer and the contents of liver cancer DNA and protein were significantlyreduced. The rates of inhibiting cancer (89.9% in group C and 35.4% in group B) were significantly increased in group C. Group C hadsignificantly long survival time compared to groups A, B and D ( P < 0.05) . By light microscopy, a number of focal necroses were foundin cancer tissue in group C.Conclusion Calcium channel blockers can enhance the antineoplastic effect of 5-Fu intraperitoneal chemotherapy to liver cancer ; Theuse of verapamil can not increase the toxicity of 5-Fu.