心血管系统中线粒体Cx43的研究进展

Connexins are transmembrane proteins.The best-known function of connexins is to form gap junction channels.Cardiomyocytes predominantly express connexin 43(Cx43).Recent studies show that Cx43 is not only present at the sarcolemma but is also detected in mitochondria of cardiomyocytes,at least in part in the inner mitochondrial membrane.Mitochondrial Cx43 plays a central role for triggering/mediating the cardioprotection by ischemic preconditioning(IPC),however the molecular mechanisms have not been elucidated in detail.The present article reviews the available evidence on the localization,the mechanism of transport,the phosphorylation status,the affecting factors and the physiological role of mitochondrial Cx43.These findings open a new field for investigating the previously unsuspected roles of Cx43 in mitochondria about their functions,regulation and molecular mechanisms involved in pathophysiology not only in myocardial ischaemia-reperfusion injury but also in other conditions in the cardiovascular system and beyond.

基于治趣APP的形成性评价在心内科见习教学中的应用

目的 探讨基于治趣APP的形成性评价在心血管内科(简称“心内科”)见习教学中的应用效果。方法 以广西医科大学2019级五年制临床医学专业本科4个班的学生为研究对象,将其随机分为观察组和对照组,每组2个班。对照组采用传统教学模式进行见习教学,观察组采用基于治趣APP的形成性评价进行见习教学。课程教学完成后,通过病例考核、综合考试、治趣APP综合评价以及问卷调查的形式对教学效果和学生的综合表现等进行比较。结果 观察组病例考核成绩、综合考试成绩以及临床思维能力表现(系统性、逻辑性、精确性、敏捷性、经济性)均高/优于对照组,差异均有统计学意义(均P<0.05)。问卷调查结果显示,观察组在理论知识掌握度、临床思维提升度、综合判断能力、分析解决问题能力以及学习积极性等方面,学生认可度高。结论 将基于治趣APP的形成性评价应用于心内科见习教学中,能够有效提升学生的临床思维能力和综合能力,教学效果好,值得在临床见习课程上推广。