The experimental uveitis was induced by injecting lens protein into the antertor cham- ber of rabbit's eye.A special fluorophotometer was used for objectively measuring the flaoreseein level in the anterior chambe...The experimental uveitis was induced by injecting lens protein into the antertor cham- ber of rabbit's eye.A special fluorophotometer was used for objectively measuring the flaoreseein level in the anterior chamber of the eve to rellect the degree of inflammation.When administered in- travenously.the inhibitory effects of flufenamic acid and mefenamic acid on experimental uveius showed a dose-dependent relationship,The former at dosages 5.0.12.5 and 250 mg kg decreased the areas under the time-response curve to 22.3%.11.5% and 9.3% of the control.respcctively:however the latter at dosages 6.2.12.5 and 25.0 mg/kg decreased the areas under the curve to 35.5%.21.0% and 8.6% of the control,respectively.When instilled by ocular route.50μl of 1% eye-drops of flufenmic acid or mefenamic acid lowered the fluoreseein levels of treated eyes as well as contra-lateral eyes.The areas under the time-response curve for treated eyes were decreased to 20.3% of the control and those of contra-lateral eyes to about 50% of the control.The results indicate that both flufenamic and mefenamic acids,applied intravenously or topically,can inhibit ocular inflammation.展开更多
文摘The experimental uveitis was induced by injecting lens protein into the antertor cham- ber of rabbit's eye.A special fluorophotometer was used for objectively measuring the flaoreseein level in the anterior chamber of the eve to rellect the degree of inflammation.When administered in- travenously.the inhibitory effects of flufenamic acid and mefenamic acid on experimental uveius showed a dose-dependent relationship,The former at dosages 5.0.12.5 and 250 mg kg decreased the areas under the time-response curve to 22.3%.11.5% and 9.3% of the control.respcctively:however the latter at dosages 6.2.12.5 and 25.0 mg/kg decreased the areas under the curve to 35.5%.21.0% and 8.6% of the control,respectively.When instilled by ocular route.50μl of 1% eye-drops of flufenmic acid or mefenamic acid lowered the fluoreseein levels of treated eyes as well as contra-lateral eyes.The areas under the time-response curve for treated eyes were decreased to 20.3% of the control and those of contra-lateral eyes to about 50% of the control.The results indicate that both flufenamic and mefenamic acids,applied intravenously or topically,can inhibit ocular inflammation.
