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Inhibition of protein tyrosine phosphatase 1B activity by triterpenes isolated from Aceriphyllum rossii
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作者 崔龙 李志 +2 位作者 孙亚楠 张南 金永镐 《Journal of Chinese Pharmaceutical Sciences》 CAS 2012年第2期178-182,共5页
An organic layer prepared from the seed of Aceriphyllum rossii was studied to identify the active compounds for protein tyrosine phosphatase 1B(PTP1B) inhibition.Bioassay guided fractionation resulted in the isolati... An organic layer prepared from the seed of Aceriphyllum rossii was studied to identify the active compounds for protein tyrosine phosphatase 1B(PTP1B) inhibition.Bioassay guided fractionation resulted in the isolation of PTP1B inhibitory activity of triterpenes(1-4).These four compounds were identified as aceriphyllic acid C(1),aceriphyllic acid D(2),aceriphyllic acid E(3) and aceriphyllic acid F(4).The isolated 1-4 compounds inhibited PTP1B with IC50 values ranged from(2.1±1.5) μmol/L to(11.2±2.5) μmol/L.Kinetic analysis of PTP1B inhibition by aceriphyllic acid C(1) and aceriphyllic acid D(2) suggested that oleanane-type triterpenes inhibited PTP1B activity in a mixed-type manner. 展开更多
关键词 Aceriphyllum rossii Protein tyrosine phosphatase 1B TRITERPENES Bioassay guided
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