The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and oth...The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and other spectral approaches.At the same time,the stoichiometric ratio,the constants and the thermodynamic parameters of inclusion complexes were determined.The experimental results demonstrated that a 1:1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was△G°<0 and△H°<0,the inclusion reaction was a spontaneous exothermal reaction.△S°<0,it was indicated that forming inclusion complex of berberine hydrochloride with β-cyclodextrin is an increased process for degree of order of molecules.Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubility,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β-cyclodextrin by current work.展开更多
目的采用响应面法优化超声提取中药茜草多糖工艺。方法在单因素实验的基础上,选择超声功率、超声温度、液料比、提取时间为影响因子,根据Box-Benhnken实验设计原理,用Design-Expert软件进行响应面分析。结果最佳提取工艺条件为超声波功...目的采用响应面法优化超声提取中药茜草多糖工艺。方法在单因素实验的基础上,选择超声功率、超声温度、液料比、提取时间为影响因子,根据Box-Benhnken实验设计原理,用Design-Expert软件进行响应面分析。结果最佳提取工艺条件为超声波功率240 W,超声温度56℃,液料比40∶1 m L/g,超声时间6 min,提取次数2次。在该条件下,中药茜草多糖的实际产率为8.75%。结论该方法准确、可靠,对工业上开发利用茜草多糖有一定的意义和价值。展开更多
文摘The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and other spectral approaches.At the same time,the stoichiometric ratio,the constants and the thermodynamic parameters of inclusion complexes were determined.The experimental results demonstrated that a 1:1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was△G°<0 and△H°<0,the inclusion reaction was a spontaneous exothermal reaction.△S°<0,it was indicated that forming inclusion complex of berberine hydrochloride with β-cyclodextrin is an increased process for degree of order of molecules.Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubility,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β-cyclodextrin by current work.
文摘目的采用响应面法优化超声提取中药茜草多糖工艺。方法在单因素实验的基础上,选择超声功率、超声温度、液料比、提取时间为影响因子,根据Box-Benhnken实验设计原理,用Design-Expert软件进行响应面分析。结果最佳提取工艺条件为超声波功率240 W,超声温度56℃,液料比40∶1 m L/g,超声时间6 min,提取次数2次。在该条件下,中药茜草多糖的实际产率为8.75%。结论该方法准确、可靠,对工业上开发利用茜草多糖有一定的意义和价值。
