本论文论述了四川比较文学自1978年到2008年的三十年的成长和发展历程,梳理了四川比较文学经历了从自我觉醒阶段,到成长为中国比较文学的生力军、被誉为中国比较文学"四大方面军"阶段,再到形成世界格局中四川比较文学这样三...本论文论述了四川比较文学自1978年到2008年的三十年的成长和发展历程,梳理了四川比较文学经历了从自我觉醒阶段,到成长为中国比较文学的生力军、被誉为中国比较文学"四大方面军"阶段,再到形成世界格局中四川比较文学这样三个历史性阶段的发展。在这三个十年时,四川比较文学建设起了以《比较文学报》、《中外文化与文论》Com-parative Literature:West and East为中心的言论阵地、培养了一批比较文学人才,形成了相对稳定的学术梯队,发表、出版了大量有价值的研究论文与专著,在中外文学关系、比较文学学科建设、比较诗学、译介学、流散文学等研究领域取得了较高的成就,并以"比较文学中国学派"、"失语症"、"异质性"、"话语重建"、"变异学"、"跨文明"等重要理论观点的提出推动了四川和全国比较文学的发展。四川比较文学三十年发展历程表明:四川比较文学对中国比较文学以及对世界比较文学学科理论发展作出了历史性贡献。展开更多
Stroke is one of three important diseases threaten healthy of human being. Ischemia stroke with high mortality and disability rate is accout for 55%-80% of stroke. Cerebral ischemia reperfusion injury is one mainly pa...Stroke is one of three important diseases threaten healthy of human being. Ischemia stroke with high mortality and disability rate is accout for 55%-80% of stroke. Cerebral ischemia reperfusion injury is one mainly pathological mechanism of ischemia stroke. The functional disturbance of the network of neuro-endocrine and immune (NEI) induced by cerebral ischemia reperfusion heighten abnormally glucocorticiod (GCS) in hippocampus and plasm ,and aggravate pathological impairment after cerebral ischemia reperfusion. Recently investigation showed that excessive GCS is one of important pathological factors causing neuron apoptosis in major brain regions such as hippocampus related to cognitive function, which is responsible for vascular dementia (VaD) after stroke. At present, the mechanism induced neuron apoptosis by higher GCS is remained unkown. JianNaoAn with function of BuShenHuoXueHuaTan, is one effective compound of Chinese herbal drug on curing VaD. The proceding experimental result has confirmed the function of JianNaoAn down-modulated genes expression of IL-1 ,CRF related to NEI and relieved impairment of nerve cells induced by cerebral ischemia -reperfusion. We investigate the action about excessive GCS causing neurons apoptosis after cerebral ischemia and the influence of JianNaoAn on this pathological machenism through radioimmunoassay (RIA), immunohistochemistry, in situ hybridization and TUNEL experimental techniques. Furthermore the protective function of JianNaoAn on neuron after cerebral ischemia-reperfusion and potentially pharmacological methanism to prevent and cure post-stroke dementia were revealed. At 2,6,12,24 h of different ischemia-reperfusion points, the concentration of cortisiol of the JianNaoAn treated group in plasm and hippocampus decreased significantly compared with the model group (P<0.05). The number of positive cells is reduced significantly compared with the model group by TUNEL staining method, especially in reperfusion 12 h,the distinction in number of positive cell between the JiaNaoAn treated group and the model group is very significant (P <0.01) . The proteins and mRNA expression of NMDAR,cytochrome C and caspase 3, which are the key genes in the apoptosis pathway of depended mitochondrion, are down-modulated in the treatment group and the antagonist group ,and there were distinct difference compared with the model group. However,there is no significant difference about the expression of glucocorticoid receptor between the treatment group and the model group. By the apoptosis pathway of dependent mitochondrion that excessive GCS caused neurons apoptosis in hippocampus is confirmed in our experiment. But JianNaoAn can reduce selectively GCS and inhibit the activity of the apoptosis pathway of dependent mitochondrion induced by excessive GCS, and then decrease the degree of apoptosis in hippocampus after cerebral ischemia- reperfusion. The protective action is one function of preventing neurons from injury resulted from cerebral ischemia-reperfusion. Meanwhile, the function of BuShenHuoXueHuaTan method on regulating the disturbance of network of NEI induced by cerebral ischemia-reperfusion may be an important biological mechanism protecting neurons, preventing and treating vascular dementia.展开更多
文摘本论文论述了四川比较文学自1978年到2008年的三十年的成长和发展历程,梳理了四川比较文学经历了从自我觉醒阶段,到成长为中国比较文学的生力军、被誉为中国比较文学"四大方面军"阶段,再到形成世界格局中四川比较文学这样三个历史性阶段的发展。在这三个十年时,四川比较文学建设起了以《比较文学报》、《中外文化与文论》Com-parative Literature:West and East为中心的言论阵地、培养了一批比较文学人才,形成了相对稳定的学术梯队,发表、出版了大量有价值的研究论文与专著,在中外文学关系、比较文学学科建设、比较诗学、译介学、流散文学等研究领域取得了较高的成就,并以"比较文学中国学派"、"失语症"、"异质性"、"话语重建"、"变异学"、"跨文明"等重要理论观点的提出推动了四川和全国比较文学的发展。四川比较文学三十年发展历程表明:四川比较文学对中国比较文学以及对世界比较文学学科理论发展作出了历史性贡献。
文摘Stroke is one of three important diseases threaten healthy of human being. Ischemia stroke with high mortality and disability rate is accout for 55%-80% of stroke. Cerebral ischemia reperfusion injury is one mainly pathological mechanism of ischemia stroke. The functional disturbance of the network of neuro-endocrine and immune (NEI) induced by cerebral ischemia reperfusion heighten abnormally glucocorticiod (GCS) in hippocampus and plasm ,and aggravate pathological impairment after cerebral ischemia reperfusion. Recently investigation showed that excessive GCS is one of important pathological factors causing neuron apoptosis in major brain regions such as hippocampus related to cognitive function, which is responsible for vascular dementia (VaD) after stroke. At present, the mechanism induced neuron apoptosis by higher GCS is remained unkown. JianNaoAn with function of BuShenHuoXueHuaTan, is one effective compound of Chinese herbal drug on curing VaD. The proceding experimental result has confirmed the function of JianNaoAn down-modulated genes expression of IL-1 ,CRF related to NEI and relieved impairment of nerve cells induced by cerebral ischemia -reperfusion. We investigate the action about excessive GCS causing neurons apoptosis after cerebral ischemia and the influence of JianNaoAn on this pathological machenism through radioimmunoassay (RIA), immunohistochemistry, in situ hybridization and TUNEL experimental techniques. Furthermore the protective function of JianNaoAn on neuron after cerebral ischemia-reperfusion and potentially pharmacological methanism to prevent and cure post-stroke dementia were revealed. At 2,6,12,24 h of different ischemia-reperfusion points, the concentration of cortisiol of the JianNaoAn treated group in plasm and hippocampus decreased significantly compared with the model group (P<0.05). The number of positive cells is reduced significantly compared with the model group by TUNEL staining method, especially in reperfusion 12 h,the distinction in number of positive cell between the JiaNaoAn treated group and the model group is very significant (P <0.01) . The proteins and mRNA expression of NMDAR,cytochrome C and caspase 3, which are the key genes in the apoptosis pathway of depended mitochondrion, are down-modulated in the treatment group and the antagonist group ,and there were distinct difference compared with the model group. However,there is no significant difference about the expression of glucocorticoid receptor between the treatment group and the model group. By the apoptosis pathway of dependent mitochondrion that excessive GCS caused neurons apoptosis in hippocampus is confirmed in our experiment. But JianNaoAn can reduce selectively GCS and inhibit the activity of the apoptosis pathway of dependent mitochondrion induced by excessive GCS, and then decrease the degree of apoptosis in hippocampus after cerebral ischemia- reperfusion. The protective action is one function of preventing neurons from injury resulted from cerebral ischemia-reperfusion. Meanwhile, the function of BuShenHuoXueHuaTan method on regulating the disturbance of network of NEI induced by cerebral ischemia-reperfusion may be an important biological mechanism protecting neurons, preventing and treating vascular dementia.
