目的:研究微小染色体维持蛋白7 (MCM7)和肿瘤相关钙信号转导蛋白2 (TACSTD2)在甲状腺乳头状癌(PTC)中的表达及临床意义。方法:采用免疫组化方法对109例甲状腺良恶性病变(甲状腺乳头状癌69例、结节性甲状腺肿组织40例、癌旁甲状腺组织69...目的:研究微小染色体维持蛋白7 (MCM7)和肿瘤相关钙信号转导蛋白2 (TACSTD2)在甲状腺乳头状癌(PTC)中的表达及临床意义。方法:采用免疫组化方法对109例甲状腺良恶性病变(甲状腺乳头状癌69例、结节性甲状腺肿组织40例、癌旁甲状腺组织69例)中MCM7和TACSTD2的表达进行检测。结果:MCM7在上述组织中的阳性表达率分别为97.1% (67/69)、65.0% (26/40)和15.94% (11/69),TACSTD2在上述组织的阳性表达率分别为98.55% (68/69)、60.0% (24/40)和17.39% (12/69)。两种蛋白在上述三种组织的阳性表达率差异均具有统计学意义(c2 = 94.5 P c2 = 93.6, P P P = 0.016, Objective: To investigate the expression and clinical significance of minosomal maintenance protein 7 (MCM7) and tumor-associated calcium signal transducer 2 (TACSTD2) in papillary thyroid carcinoma (PTC). Methods: Immunohistochemistry was used to detect the expression of MCM7 and TACSTD2 in 109 cases of benign and malignant thyroid lesions (69 cases of papillary thyroid carcinoma, 40 cases of nodular goiter and 69 cases of adjacent thyroid tissues). Results: The positive expression rates of MCM7 in the above tissues were 97.1% (67/69), 65.0% (26/40) and 15.94% (11/69), respectively. The positive expression rates of TACSTD2 in the above tissues were 98.55% (68/69), 60.0% (24/40) and 17.39% (12/69), respectively. The positive expression rates of the two proteins in the above three tissues were statistically significant (c2 = 94.5, P c2 = 93.6, P P P = 0.016, < 0.05). Conclusions: MCM7 and TACSTD2 are highly expressed in PTC tissues, and the positive expression of TACSTD2 is positively correlated with tumor diameter, which may be involved in the occurrence and development of PTC. Both of them may provide new molecular biological markers for the diagnosis of PTC.展开更多
目的探讨与分析择期宫颈环扎联合间苯三酚治疗宫颈机能不全对孕妇妊娠结局的影响。方法方便选取2017年7月—2023年2月于日照市中心医院诊治的宫颈机能不全孕妇74例作为研究对象,根据随机数表法分为间苯三酚组37例与对照组37例。对照组...目的探讨与分析择期宫颈环扎联合间苯三酚治疗宫颈机能不全对孕妇妊娠结局的影响。方法方便选取2017年7月—2023年2月于日照市中心医院诊治的宫颈机能不全孕妇74例作为研究对象,根据随机数表法分为间苯三酚组37例与对照组37例。对照组给予择期宫颈环扎治疗,间苯三酚组在对照组治疗的基础上给予间苯三酚治疗,记录两组的妊娠结局。结果间苯三酚组的手术时间、术中出血量、术后住院天数均优于对照组,差异有统计学意义(P均<0.05);间苯三酚组分娩孕周明显多于对照组,差异有统计学意义(P<0.05);间苯三酚组的宫内感染率、晚期流产率、足月分娩率分别为5.41%、2.70%、94.59%,均优于对照组的21.62%、18.92%、78.38%,差异有统计学意义(χ^(2)=4.162、5.045、4.162,P均<0.05);间苯三酚组的围产儿存活率显著高于对照组,差异有统计学意义(P<0.05);且间苯三酚组存活围产儿的出生体质量、5 min Apgar评分、1 min Apgar评分均高于对照组,差异有统计学意义(P均<0.05)。结论择期宫颈环扎联合间苯三酚治疗宫颈机能不全能促进患者康复,延长分娩孕周,改善存活围产儿的出生结局。展开更多
文摘目的:研究微小染色体维持蛋白7 (MCM7)和肿瘤相关钙信号转导蛋白2 (TACSTD2)在甲状腺乳头状癌(PTC)中的表达及临床意义。方法:采用免疫组化方法对109例甲状腺良恶性病变(甲状腺乳头状癌69例、结节性甲状腺肿组织40例、癌旁甲状腺组织69例)中MCM7和TACSTD2的表达进行检测。结果:MCM7在上述组织中的阳性表达率分别为97.1% (67/69)、65.0% (26/40)和15.94% (11/69),TACSTD2在上述组织的阳性表达率分别为98.55% (68/69)、60.0% (24/40)和17.39% (12/69)。两种蛋白在上述三种组织的阳性表达率差异均具有统计学意义(c2 = 94.5 P c2 = 93.6, P P P = 0.016, Objective: To investigate the expression and clinical significance of minosomal maintenance protein 7 (MCM7) and tumor-associated calcium signal transducer 2 (TACSTD2) in papillary thyroid carcinoma (PTC). Methods: Immunohistochemistry was used to detect the expression of MCM7 and TACSTD2 in 109 cases of benign and malignant thyroid lesions (69 cases of papillary thyroid carcinoma, 40 cases of nodular goiter and 69 cases of adjacent thyroid tissues). Results: The positive expression rates of MCM7 in the above tissues were 97.1% (67/69), 65.0% (26/40) and 15.94% (11/69), respectively. The positive expression rates of TACSTD2 in the above tissues were 98.55% (68/69), 60.0% (24/40) and 17.39% (12/69), respectively. The positive expression rates of the two proteins in the above three tissues were statistically significant (c2 = 94.5, P c2 = 93.6, P P P = 0.016, < 0.05). Conclusions: MCM7 and TACSTD2 are highly expressed in PTC tissues, and the positive expression of TACSTD2 is positively correlated with tumor diameter, which may be involved in the occurrence and development of PTC. Both of them may provide new molecular biological markers for the diagnosis of PTC.
文摘目的探讨与分析择期宫颈环扎联合间苯三酚治疗宫颈机能不全对孕妇妊娠结局的影响。方法方便选取2017年7月—2023年2月于日照市中心医院诊治的宫颈机能不全孕妇74例作为研究对象,根据随机数表法分为间苯三酚组37例与对照组37例。对照组给予择期宫颈环扎治疗,间苯三酚组在对照组治疗的基础上给予间苯三酚治疗,记录两组的妊娠结局。结果间苯三酚组的手术时间、术中出血量、术后住院天数均优于对照组,差异有统计学意义(P均<0.05);间苯三酚组分娩孕周明显多于对照组,差异有统计学意义(P<0.05);间苯三酚组的宫内感染率、晚期流产率、足月分娩率分别为5.41%、2.70%、94.59%,均优于对照组的21.62%、18.92%、78.38%,差异有统计学意义(χ^(2)=4.162、5.045、4.162,P均<0.05);间苯三酚组的围产儿存活率显著高于对照组,差异有统计学意义(P<0.05);且间苯三酚组存活围产儿的出生体质量、5 min Apgar评分、1 min Apgar评分均高于对照组,差异有统计学意义(P均<0.05)。结论择期宫颈环扎联合间苯三酚治疗宫颈机能不全能促进患者康复,延长分娩孕周,改善存活围产儿的出生结局。
