使用内充气正比计数管测量放射性气体活度是放射性气体活度绝对测量的最主要方法之一.基于Geant4(GEometry ANd Tracking 4)的模拟数据,研究了内充气正比计数法测量活度的过程中,壁效应和小脉冲幅度的修正方法本身对最终活度测量的不确...使用内充气正比计数管测量放射性气体活度是放射性气体活度绝对测量的最主要方法之一.基于Geant4(GEometry ANd Tracking 4)的模拟数据,研究了内充气正比计数法测量活度的过程中,壁效应和小脉冲幅度的修正方法本身对最终活度测量的不确定度的影响.根据模拟结果,得到如下结论:为达到0.3％以下的不确定度,3H与85Kr的测量下阈应分别低于0.2 keV和0.6 keV;壁效应对3H的影响较小,对85Kr的影响较大,但其结果可通过改变气体压强的方法修正到0.3％以内的不确定度.展开更多
α放射性核素靶向治疗(targeted alpha therapy,TAT)技术作为一种很有前景的肿瘤放疗手段近些年来正不断发展。因α放射性核素具有线性传能密度(linear energy transfer,LET)高、射程短、放射生物学效应和细胞毒性强等特点,TAT在微小肿...α放射性核素靶向治疗(targeted alpha therapy,TAT)技术作为一种很有前景的肿瘤放疗手段近些年来正不断发展。因α放射性核素具有线性传能密度(linear energy transfer,LET)高、射程短、放射生物学效应和细胞毒性强等特点,TAT在微小肿瘤、散在性肿瘤及发生微转移肿瘤的治疗上展现出了独特的优势。但是,由于可用于TAT的α核素来源非常有限,且其制备和纯化也十分困难,这就导致α核素的获取成为了制约TAT技术发展的主要因素之一。针对α放射性核素靶向治疗中α核素的获取问题,本文从核素的性质、制备技术及分离方法的角度对几种适用于靶向治疗的α放射性核素(^(225)Ac、^(213)Bi、^(212)Pb、^(212)Bi、^(227)Th、^(223)Ra、^(230)U、^(226)Th、^(211)At、^(149)Tb)的研究现状进行了概述。展开更多
Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,e...Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,exhibit significant photo‑physicochemical properties that make them attractive for various applications.Herein,this review comprehensively discusses the remarkable properties of corrole complexes,as well as related structures and chelation properties.It further explores the biological applications of corrole complexes for in vivo imaging and anticancer therapy.Additionally,it addresses common research bottlenecks and challenges,providing insights into future potential applications in disease diagnosis and treatment.Generally,this review aims to illuminate the significance of corrole complexes and their promising biological applications.展开更多
文摘α放射性核素靶向治疗(targeted alpha therapy,TAT)技术作为一种很有前景的肿瘤放疗手段近些年来正不断发展。因α放射性核素具有线性传能密度(linear energy transfer,LET)高、射程短、放射生物学效应和细胞毒性强等特点,TAT在微小肿瘤、散在性肿瘤及发生微转移肿瘤的治疗上展现出了独特的优势。但是,由于可用于TAT的α核素来源非常有限,且其制备和纯化也十分困难,这就导致α核素的获取成为了制约TAT技术发展的主要因素之一。针对α放射性核素靶向治疗中α核素的获取问题,本文从核素的性质、制备技术及分离方法的角度对几种适用于靶向治疗的α放射性核素(^(225)Ac、^(213)Bi、^(212)Pb、^(212)Bi、^(227)Th、^(223)Ra、^(230)U、^(226)Th、^(211)At、^(149)Tb)的研究现状进行了概述。
文摘Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,exhibit significant photo‑physicochemical properties that make them attractive for various applications.Herein,this review comprehensively discusses the remarkable properties of corrole complexes,as well as related structures and chelation properties.It further explores the biological applications of corrole complexes for in vivo imaging and anticancer therapy.Additionally,it addresses common research bottlenecks and challenges,providing insights into future potential applications in disease diagnosis and treatment.Generally,this review aims to illuminate the significance of corrole complexes and their promising biological applications.
