Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ische...Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ischemia reperfusion injury(CIRI)is one of the most important pathological injuries after ischemic stroke,and the effective treatment has always been a research focus at home and abroad.The proposal of the concept of neurovascular unit(NVU)which extends treatment ideas from local to holistic is in accordance with the holistic concept and treatment based on syndrome differentiation in Chinese medicine.Chinese medicine has many advantages,such as being multicomponent,multitarget,and multipath while stem cells are effective biological therapeutic means,both of which have been proved to exert comprehensive and definite effects on NVU injury caused by CIRI.This artide reviews the molecular mechanisms of NVU injury and the cerebropro-tective effects of Chinese medicine monomers or compound formulas combined with MSCs on NUV injury after cerebral ischemia,with a view to provide a theoretical basis for future studies.展开更多
The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogen...The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions.展开更多
Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Me...Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Methods Candidate compounds and potential targets were identifed through the TCM Systems Pharmacology database and a comprehensive literature search.Related targets of STS and ASO were collected in the GeneCards database,DisGeNET database,and Drugbank database.Furthermore,The STRING 11.0 database was used to determine protein-protein interaction(PPI)networks;common targets were obtained and imported into Cytoscape 3.7.2.Then,a PPI network comprising common targets was drawn,and network topology analysis was performed to screen for key shared targets.Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software.Subsequently.a compound-target-pathway network was constructed via Cytoscape 3.7.2.Results The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO:AGE-RAGE signaling pathway,IL-17 signaling pathway;HIF-1 signaling pathway,TNF signaling pathway,interactions between cytokines and cytokine receptors,Th17 cell differentiation,and NOD-like receptor signaling pathway.Among the compounds and targets involved in these pathways,quercetin,luteolin,and kaempferol were found to be core compounds,and TNF,IL-6,and MAPK1 were found to be core targets.Conclusion Taken together,our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation,angiogen-esis,inflammation,immune responses,oxidative stress,and other related signaling pathways.展开更多
Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD b...Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.展开更多
Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine(TCM)in the treatment of AIDS diarrhea.Methods The computer system was used to comprehensively search database of ...Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine(TCM)in the treatment of AIDS diarrhea.Methods The computer system was used to comprehensively search database of Wanfang(WF),VIP,and China National Knowledge Infrastructure(CNKI)for relevant literature on the application effect of Chinese medicine in the treatment of AIDs diarrhea.The retrieval time was set from January 1,2010 to August 15,2021.The documents that did not meet the inclusion criteria were eliminated,and the quality of the qualified literature was evaluated according to the improved Jadad scoring standard.The main outcome indicators were entered into the literature,and Review Manager 5.0 software was used for meta-analysis.Results Eight eligible articles were included,a total of 536 cases of AIDS diarrhea patients were included.All eight eligible articles observed the clinical efficacy of TCM in the treatment of AIDS diarrhea,among which four observed the TCM syndrome changes in the treatment of AIDS diarrhea,and four observed adverse reactions of TCM in the treatment of AIDS diarrhea.All articles were extracted for valid data.After entering all the main observation index data,the results of meta-analysis showed that the effect of TCM in the treatment of AIDS diarrhea was better,the differencewas statistically significant[MD=2.92,95%CI(1.81,4.70),p<0.001];TCM in the treatment of AIDS diarrhea was more conducive to improving the TCM syndrome scores of patients,the difference was statistically significant[MD=-2.55,95%CI(-3.37,-1.73),p<0.001];the adverse effects of TCM in the treatment of AIDS diarrhea were mild,and the difference was statistically significant[MD=1.70,95%Cl(0.48,5.97),p=0.41].Conclusion The effect of TCM in the treatment of AIDS diarrhea patients is remarkable,which can effectively improve the TCM symptom scores of patients without increasing the incidence of adverse reactions.展开更多
Traditional Chinese medicine(TCM)has played an important role in the prevention and control of coronavirus disease 2019(COvID-19)and has received considerable attention from all sectors of society.In the current situa...Traditional Chinese medicine(TCM)has played an important role in the prevention and control of coronavirus disease 2019(COvID-19)and has received considerable attention from all sectors of society.In the current situation of the global outbreak,it is crucial to promote the global application of TCM.However,the pandemic has also exposed various problems affecting the widespread acceptance of TCM.In this review,we summarize efforts to prevent and control cOoVID-19 by TCM and provide strategic guidance on how to promote its practice in the context of public health emergencies by(1)completing the system for evaluating the clinical efficacy of TCM;(2)transforming decoctions into Chinese patent medicines;(3)encouraging low-threshold traditional rehabilitation therapy;(4)strengthening communication and cooperation with the media.The aim of these approaches is to improve the rigor of TCM research and its dissemination,sharing the antiepidemic experience of TCM to the world,as well as increase the engagement of and acceptance by the masses.In this manner,TCM will not only aid in preventing and controlling CoVID-19 but can also provide tools for coping withfuture public health emergencies.展开更多
基金We thank for the funding support from the National Natural Science Foundation of China(8197151612)Henan Provincial Project of Outstanding Talents in Science and Technology Innovation(2018JR0006).
文摘Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ischemia reperfusion injury(CIRI)is one of the most important pathological injuries after ischemic stroke,and the effective treatment has always been a research focus at home and abroad.The proposal of the concept of neurovascular unit(NVU)which extends treatment ideas from local to holistic is in accordance with the holistic concept and treatment based on syndrome differentiation in Chinese medicine.Chinese medicine has many advantages,such as being multicomponent,multitarget,and multipath while stem cells are effective biological therapeutic means,both of which have been proved to exert comprehensive and definite effects on NVU injury caused by CIRI.This artide reviews the molecular mechanisms of NVU injury and the cerebropro-tective effects of Chinese medicine monomers or compound formulas combined with MSCs on NUV injury after cerebral ischemia,with a view to provide a theoretical basis for future studies.
基金supported by"Hundred-Thousand-Ten Thousand"Talents Project of Chinese Medicine Inheritance and Innovation(Qihuang Project)-Qihuang Scholars(284 Official Letter of People's Education of Chinese Medicine 2018)Special Scientific Research Project of National Clinical Research Base of Traditional Chinese Medicine(2019JDZX001)+2 种基金Special Scientific Research Project of National Clinical Research Base of Chinese Medicine(2019JDZX028)Key Scientific Research Project of Henan Province Colleges and Universities(20A360005)Henan Province Science and Technology Research and Social Development Project(202102310497).
文摘The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions.
基金supported by 2018 scientific and technological research projectsin Henan Province(192102310430)Special Project of Chinese Medicine Research in Henan Province(2019ZYZD06)。
文摘Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Methods Candidate compounds and potential targets were identifed through the TCM Systems Pharmacology database and a comprehensive literature search.Related targets of STS and ASO were collected in the GeneCards database,DisGeNET database,and Drugbank database.Furthermore,The STRING 11.0 database was used to determine protein-protein interaction(PPI)networks;common targets were obtained and imported into Cytoscape 3.7.2.Then,a PPI network comprising common targets was drawn,and network topology analysis was performed to screen for key shared targets.Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software.Subsequently.a compound-target-pathway network was constructed via Cytoscape 3.7.2.Results The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO:AGE-RAGE signaling pathway,IL-17 signaling pathway;HIF-1 signaling pathway,TNF signaling pathway,interactions between cytokines and cytokine receptors,Th17 cell differentiation,and NOD-like receptor signaling pathway.Among the compounds and targets involved in these pathways,quercetin,luteolin,and kaempferol were found to be core compounds,and TNF,IL-6,and MAPK1 were found to be core targets.Conclusion Taken together,our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation,angiogen-esis,inflammation,immune responses,oxidative stress,and other related signaling pathways.
基金supported by the National Key Research Project(2020YFE0201800)Henan Province Science and Technology Program for Tackling Key Problems(21210230347)2021 Postgraduate Scientifc Re-search Innovation Progrpm of Henan Universityof Chinese Medicine(2021KYCX008).
文摘Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.
基金funded by National Natural Science Foundation of China(U1604287)National Science and Tech-nology Major Project During the“13th Five-Year”Plan Period(2017ZX10205502).
文摘Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine(TCM)in the treatment of AIDS diarrhea.Methods The computer system was used to comprehensively search database of Wanfang(WF),VIP,and China National Knowledge Infrastructure(CNKI)for relevant literature on the application effect of Chinese medicine in the treatment of AIDs diarrhea.The retrieval time was set from January 1,2010 to August 15,2021.The documents that did not meet the inclusion criteria were eliminated,and the quality of the qualified literature was evaluated according to the improved Jadad scoring standard.The main outcome indicators were entered into the literature,and Review Manager 5.0 software was used for meta-analysis.Results Eight eligible articles were included,a total of 536 cases of AIDS diarrhea patients were included.All eight eligible articles observed the clinical efficacy of TCM in the treatment of AIDS diarrhea,among which four observed the TCM syndrome changes in the treatment of AIDS diarrhea,and four observed adverse reactions of TCM in the treatment of AIDS diarrhea.All articles were extracted for valid data.After entering all the main observation index data,the results of meta-analysis showed that the effect of TCM in the treatment of AIDS diarrhea was better,the differencewas statistically significant[MD=2.92,95%CI(1.81,4.70),p<0.001];TCM in the treatment of AIDS diarrhea was more conducive to improving the TCM syndrome scores of patients,the difference was statistically significant[MD=-2.55,95%CI(-3.37,-1.73),p<0.001];the adverse effects of TCM in the treatment of AIDS diarrhea were mild,and the difference was statistically significant[MD=1.70,95%Cl(0.48,5.97),p=0.41].Conclusion The effect of TCM in the treatment of AIDS diarrhea patients is remarkable,which can effectively improve the TCM symptom scores of patients without increasing the incidence of adverse reactions.
文摘Traditional Chinese medicine(TCM)has played an important role in the prevention and control of coronavirus disease 2019(COvID-19)and has received considerable attention from all sectors of society.In the current situation of the global outbreak,it is crucial to promote the global application of TCM.However,the pandemic has also exposed various problems affecting the widespread acceptance of TCM.In this review,we summarize efforts to prevent and control cOoVID-19 by TCM and provide strategic guidance on how to promote its practice in the context of public health emergencies by(1)completing the system for evaluating the clinical efficacy of TCM;(2)transforming decoctions into Chinese patent medicines;(3)encouraging low-threshold traditional rehabilitation therapy;(4)strengthening communication and cooperation with the media.The aim of these approaches is to improve the rigor of TCM research and its dissemination,sharing the antiepidemic experience of TCM to the world,as well as increase the engagement of and acceptance by the masses.In this manner,TCM will not only aid in preventing and controlling CoVID-19 but can also provide tools for coping withfuture public health emergencies.
