Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as ind...Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.展开更多
Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular s...Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition.The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility.The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification.Such multilayered endovascular stents with excellent hemocompatibilty and human endothelial cytocompatibility may have great potential in clinical applications.展开更多
A study of viscoelastic properties of graphite（GP） filled high density polyethylene composites was carried out.The Mooney equation was modified to evaluate the formation and development of agglomerate structure for ...A study of viscoelastic properties of graphite（GP） filled high density polyethylene composites was carried out.The Mooney equation was modified to evaluate the formation and development of agglomerate structure for high filled suspension system.The apparent filler concentration（φ） was substituted by the effective volume fraction,φeff.It is believed that in the case of high filler concentrations the viscoelastic properties of the composites are mainly related with φeff.Here,we define φeff=fφ,in which f（f≥1） is the experiential factor of effective volume,corresponding to the microstructure with different relaxation time in HDPE/GP system.In the low φ region,the viscoelastic properties of the composites can be described by the original Mooney equation,while the viscoelastic properties of the high loading composites can be described by the modified Mooney equation considering the effective filler volume in the case of ω=0.1 rad/s,experientially postulate f=1.55.展开更多
文摘Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.
基金Supported by the National Natural Science Foundation of China (20774078)the Special Funds for National Basic Research Program of China (973 Program,G2005CB623802)the Scientific Research Foundation for Returned Scholars,Ministry of Education of China
文摘Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition.The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility.The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification.Such multilayered endovascular stents with excellent hemocompatibilty and human endothelial cytocompatibility may have great potential in clinical applications.
文摘A study of viscoelastic properties of graphite（GP） filled high density polyethylene composites was carried out.The Mooney equation was modified to evaluate the formation and development of agglomerate structure for high filled suspension system.The apparent filler concentration（φ） was substituted by the effective volume fraction,φeff.It is believed that in the case of high filler concentrations the viscoelastic properties of the composites are mainly related with φeff.Here,we define φeff=fφ,in which f（f≥1） is the experiential factor of effective volume,corresponding to the microstructure with different relaxation time in HDPE/GP system.In the low φ region,the viscoelastic properties of the composites can be described by the original Mooney equation,while the viscoelastic properties of the high loading composites can be described by the modified Mooney equation considering the effective filler volume in the case of ω=0.1 rad/s,experientially postulate f=1.55.
