目的分析Web of Science收录的中药毒性相关文献,了解中药毒性现代研究发展现状。方法检索Web of Science建库至2018年12月31日的中药毒性相关文献,分析中药毒性领域文献年代分布、被引情况、研究领域、研究方向、地区和机构分布、期刊...目的分析Web of Science收录的中药毒性相关文献,了解中药毒性现代研究发展现状。方法检索Web of Science建库至2018年12月31日的中药毒性相关文献,分析中药毒性领域文献年代分布、被引情况、研究领域、研究方向、地区和机构分布、期刊分布。结果共纳入文献6933篇,20世纪90年代前研究者对中药毒性关注较少,20世纪90年代中药毒性研究稳中有增,21世纪中药毒性相关文献发文量增长迅速。研究领域涉及范围较广,研究方向出现多专业交叉现象,发文量最高的前2位国家分别为中国、美国,发文机构主要为中国医学科学院/北京协和医学院、中国科学院、香港中文大学,文献来源期刊前2位为JOURNAL OF ETHNOPHARMACOLOGY和THE AMERICAN JOURNAL OF CHINESE MEDICINE。结论近年来国际上关于中药毒性的研究增多,该领域发展态势良好,中药毒性/安全性研究仍需加强。展开更多
Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may...Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.展开更多
文摘目的分析Web of Science收录的中药毒性相关文献,了解中药毒性现代研究发展现状。方法检索Web of Science建库至2018年12月31日的中药毒性相关文献,分析中药毒性领域文献年代分布、被引情况、研究领域、研究方向、地区和机构分布、期刊分布。结果共纳入文献6933篇,20世纪90年代前研究者对中药毒性关注较少,20世纪90年代中药毒性研究稳中有增,21世纪中药毒性相关文献发文量增长迅速。研究领域涉及范围较广,研究方向出现多专业交叉现象,发文量最高的前2位国家分别为中国、美国,发文机构主要为中国医学科学院/北京协和医学院、中国科学院、香港中文大学,文献来源期刊前2位为JOURNAL OF ETHNOPHARMACOLOGY和THE AMERICAN JOURNAL OF CHINESE MEDICINE。结论近年来国际上关于中药毒性的研究增多,该领域发展态势良好,中药毒性/安全性研究仍需加强。
基金Funding Grants from University of Macao Research Grants(MYRG2015-00160-ICMS-QRCM and MYRG2014-00069-ICMS-QRCM)
文摘Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.
