女性盆腔脏器脱垂（female pelvic organ prolapse,FPOP）是一种常见的盆底功能障碍性疾病,是指由于盆底肌肉和盆底支持组织的薄弱,导致盆腔脏器下降,从而引起的脏器位置和功能异常。FPOP多发于40岁以上的中老年女性^（[1]）,尽管不会...女性盆腔脏器脱垂（female pelvic organ prolapse,FPOP）是一种常见的盆底功能障碍性疾病,是指由于盆底肌肉和盆底支持组织的薄弱,导致盆腔脏器下降,从而引起的脏器位置和功能异常。FPOP多发于40岁以上的中老年女性^（[1]）,尽管不会威胁生命,但严重影响患者的生活^（[2]）。展开更多
Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may...Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.展开更多
文摘女性盆腔脏器脱垂（female pelvic organ prolapse,FPOP）是一种常见的盆底功能障碍性疾病,是指由于盆底肌肉和盆底支持组织的薄弱,导致盆腔脏器下降,从而引起的脏器位置和功能异常。FPOP多发于40岁以上的中老年女性^（[1]）,尽管不会威胁生命,但严重影响患者的生活^（[2]）。
基金Funding Grants from University of Macao Research Grants(MYRG2015-00160-ICMS-QRCM and MYRG2014-00069-ICMS-QRCM)
文摘Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.
