基金supported by the National Natural Science Foundation of China (No. 81400695)the Natural Science Foundation of Anhui Province,China (No. 1508085QH153, 1908085QC132)+1 种基金the Natural Science Research Project Fund for Colleges and Universities in Anhui Province,China (No. KJ2019A0408)the Foundation of Wannan Medical College (No. WK202024)。