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从“火与元气不两立”探讨子宫颈癌的病机及防治
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作者 邱佳慧 纪立金 许金榜 《中华养生保健》 2024年第13期72-76,共5页
子宫颈癌是常见的妇科恶性肿瘤,文章以其临床症状切入,结合“火与元气不两立”之理,提出子宫颈癌各阶段频频呈现正邪相互博弈一负一胜的病理表现,并指出正邪博弈的关键在于脾枢调衡,阐明脾虚枢机不利是子宫颈癌的核心病机,健脾调枢是治... 子宫颈癌是常见的妇科恶性肿瘤,文章以其临床症状切入,结合“火与元气不两立”之理,提出子宫颈癌各阶段频频呈现正邪相互博弈一负一胜的病理表现,并指出正邪博弈的关键在于脾枢调衡,阐明脾虚枢机不利是子宫颈癌的核心病机,健脾调枢是治疗方法。选用补脾胃泻阴火升阳汤为主方治疗,并论述各阶段病机特点及防治要点,指导主方临证加减,具体如下:发病前,湿盛、阴不足并见,加予祛湿养阴;发病早期,正气不足是决定发病的关键因素,加予补气,辅以抗邪;发病中期,湿盛瘀毒下注营造利于癌灶生长的局部环境,加予祛湿化瘀攻毒,辅以补养气血;发病晚期,湿盛瘀毒下注、日久气血虚衰,加予补养气血,酌以祛湿化瘀攻毒。康复期,病灶去,气血耗伤,机体仍属脾虚枢机不利,以防复为主,补养气血、健脾调枢。 展开更多
关键词 子宫颈癌 火与元气不两立 脾虚枢机不利 补脾胃泻阴火升阳汤
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针药人工周期疗法对痰湿型多囊卵巢综合征患者MAPK/ERK途径的影响 被引量:14
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作者 许金榜 杨娟 +4 位作者 游秀密 张俊新 林秋平 顿晶晶 林莺 《中国中西医结合杂志》 CAS CSCD 北大核心 2018年第4期415-420,共6页
目的探讨针药人工周期疗法改善痰湿型多囊卵巢综合征(PCOS)生殖内分泌紊乱的作用机制。方法 70例脾肾亏虚、痰湿内阻型的PCOS并发胰岛素抵抗(IR)患者,随机分为对照组及治疗组,每组35例。治疗组根据不同月经阶段分期给予针灸、中药及二... 目的探讨针药人工周期疗法改善痰湿型多囊卵巢综合征(PCOS)生殖内分泌紊乱的作用机制。方法 70例脾肾亏虚、痰湿内阻型的PCOS并发胰岛素抵抗(IR)患者,随机分为对照组及治疗组,每组35例。治疗组根据不同月经阶段分期给予针灸、中药及二甲双胍治疗;对照组仅口服二甲双胍治疗。两组治疗时间均为12周。观察两组患者排卵率、妊娠率,检测黄体生成素(LH)、卵泡刺激素(FSH)、催乳素(PRL)、雌二醇(E_2)、T及LH/FSH水平,并检测胰岛素促有丝分裂通路MAPK/ERK途径相关基因(INSR、IRS、ERK1、ERK2)mRNA、蛋白表达及磷酸化水平。结果最终治疗组32例,对照组30例完成研究。治疗组治疗后排卵率为89.2%(74/83),妊娠率为58.6%(17/29),均高于对照组的排卵率[74.2%(46/62)]和妊娠率[26.1%(6/23),P<0.05]。与治疗前比较,两组LH、LH/FSH、T水平、P-ERK1、ERK1磷酸化比例降低(P<0.05),且治疗组低于对照组(P<0.05)。两组FSH、PRL、E_2水平、INSR、IRS、ERK1、ERK2 mRNA与蛋白表达水平比较,差异无统计学意义(P>0.05)。结果针药人工周期疗法可能通过MAPK/ERK通路改善多囊卵巢综合征患者生殖内分泌紊乱,提高患者的排卵率和妊娠率。 展开更多
关键词 多囊卵巢综合征 生殖内分泌 信号通路 中医药疗法 人工周期
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Effect of electroacupuncture combined with ginger-isolated moxibustion on endometrial receptivity in infertile patients with polycystic ovarian syndrome 被引量:13
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作者 Qiu-Ping LIN Ying LIU +3 位作者 Jin-bang XU Juan YANG Xiu-mi YOU Jun-Xin ZHANG 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第1期15-20,共6页
Objective:To observe the effect of the combined therapy of electroacupuncture(EA) and ginger-isolated moxibustion on endometrial receptivity in the patients with polycystic ovarian syndrome(PCOS).Methods:A total of 70... Objective:To observe the effect of the combined therapy of electroacupuncture(EA) and ginger-isolated moxibustion on endometrial receptivity in the patients with polycystic ovarian syndrome(PCOS).Methods:A total of 70 subjects of PCOS were randomized into two groups,35 cases in each one.In the western medication group,letrozole and human chorionic gonadotropin(HCG) were administered.In the combined therapy group,on the base of the treatment as the western medication group,the artificial cycle therapy with EA and ginger-isolated moxibustion was provided.The treatment duration was 3 menstrual cycles in two groups.After treated for 3 menstrual cycles,the symptom score of traditional Chinese medicine(TCM),endometrial thickness,the number of ovulation cycle,endometrial morphology,bilateral uterine artery pulsatility index(PI),resistance index(RI),the sum of peak systolic velocity/end diastolic velocity(S/D) and pregnancy were compared in the patients between two groups.Results:(1) After treatment,the endometrial thickness was better(0.21 ± 0.13 vs 0.14 ± 0.08,P <0.01),TCM symptom score reducing range was larger(5.00 ± 2.24 vs 0.52 ± 1.66,P <0.01),the reducing degrees of bilateral uterine artery PI,RI and S/D sum were better(0.62 ± 0.26 vs 0.04 ± 0.15,0.08± 0.05 vs0.01±0.05,0.61±0.33 vs 0.07±0.17,0.11±0.05 vs 0.01 ± 0.05,4.80±1.14 vs 0.15 ± 0.89,all P <0.01) in the combined therapy group respectively as compared with the western medication group.After treatment,the number of ovulation cycle and the proportion of A+B type of endometrial morphological were higher in the combined therapy group(2.09 ± 0.78 vs 1.27 ± 0.84,87.5% vs 60.61%,P <0.01,P <0.05) as compared with the western medication group respectively.(2) The clinical pregnancy rate was56.25% in the combined therapy group,better than 30.30% in the western medication group(P <0.05).The early abortion rate was 10.53% in the combined therapy group,lower than 50.00% in the western medication group(P <0.05).Conclusion:The combined treatment of electroacupuncture and ginger-isolated moxibustion with western medication effectively improves endometrial receptivity,increases clinical pregnancy rate and reduces early abortion rate in the patients with PCOS. 展开更多
关键词 ELECTROACUPUNCTURE Ginger-isolated moxibustion Polycystic ovarian syndrome(PCOS) Endometrial receptivity
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