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肥大细胞与腧穴 被引量:2
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作者 冷三华 景向红 +18 位作者 韩松平 王富春 巩昌镇 刘京 郭义 陈波 李灿辉 杨观虎 潘卫星 彭增福 陈德诚 金观源 郭松鹏 刘宏伟 陈大志 苏红 李永明 王少白 朱兵 《中华中医药学刊》 CAS 北大核心 2024年第1期16-21,共6页
皮肤活检发现肥大细胞密集是经脉腧穴和微针系统针刺靶点的共同特点。肥大细胞与神经纤维、微血管在组织分布毗邻。外界机械或温度等物理刺激可激活肥大细胞,释放多种细胞因子和化学因子,形成局部炎症性内环境,导致周围C神经等结构敏化... 皮肤活检发现肥大细胞密集是经脉腧穴和微针系统针刺靶点的共同特点。肥大细胞与神经纤维、微血管在组织分布毗邻。外界机械或温度等物理刺激可激活肥大细胞,释放多种细胞因子和化学因子,形成局部炎症性内环境,导致周围C神经等结构敏化。敏化的C神经释放P物质(SP)、降钙素基因相关肽(CGRP)。SP激活肥大细胞,CGRP促进局部微血管扩张而渗透性增加,血浆外渗,白细胞浸润,促进周围组织敏化。肥大细胞激活与C神经纤维敏化之间的反复循环持久存在会导致中枢敏化。周围与中枢敏化表现为腧穴区域敏化,包括对温度的敏化和对压痛的敏化,成为针刺和艾灸靶组织的重要特征。 展开更多
关键词 经脉 腧穴 肥大细胞 C神经纤维 穴位敏化
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抗炎针灸的理念及其临床应用前景
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作者 金观源 《中华中医药学刊》 CAS 北大核心 2024年第8期16-24,共9页
近20年来,随着炎症反射的发现与免疫反应神经调制机制越来越深入地研究,以刺激神经为主要特征的针灸疗法也有了更多的临床或实验证据表明它确实具有局部或系统性的抗炎效应,其作用机制的认知也已经深入到细胞层面。首先回顾了炎症的冗... 近20年来,随着炎症反射的发现与免疫反应神经调制机制越来越深入地研究,以刺激神经为主要特征的针灸疗法也有了更多的临床或实验证据表明它确实具有局部或系统性的抗炎效应,其作用机制的认知也已经深入到细胞层面。首先回顾了炎症的冗余神经调制对于维持生命稳态的意义,以及针灸是如何从穴位到靶器官发挥抗炎作用的过程;然后提出了“抗炎针灸”的理念,它起码包括三层内涵:首先是在疾病或损伤之初,针灸可以预防或减轻病原体感染或组织损伤导致的炎症;二是当炎症已经发生甚至发展到严峻的阶段时,针灸及时干预可以缓解或减轻炎症症状,甚至挽救生命;三是在慢性炎症状态下,针灸有助于打破致炎-抗炎的平衡(准炎症状态),使炎症朝缓解的方向发展,这特别适合那些处于低度炎症状态的慢性病、老年病的治疗。接着介绍了抗炎针灸处方的一般原则,包括穴位作用的相对特异性,最佳刺激工具或手段以及适宜刺激参数的选择。最后展望了抗炎针灸的四大临床应用前景:炎症性疼痛、感染性炎症、炎症性疾病与炎症相关性疾病;提出抗炎针灸将有助于解决现代医学至今尚十分棘手的许多炎症难题,成为推动全球针灸医学进一步发展的动力。 展开更多
关键词 炎症 神经调制 针灸 抗炎针灸 炎症性疼痛 感染性炎症 炎症性疾病 炎症相关性疾病
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Chinese Herbs for Pharyngitis Including COVID-19-Related Sore Throat 被引量:1
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作者 Guanyuan Jin Louis Lei Jin 《Chinese Medicine and Natural Products》 2022年第4期185-192,共8页
Sore throatis one of the most prominentclinical manifestations seen among mild cases of coronavirus disease 2019(COVID-19).Traditional Chinese medicine(TCM)modalities,especially Chinese herbs,have accumulated rich exp... Sore throatis one of the most prominentclinical manifestations seen among mild cases of coronavirus disease 2019(COVID-19).Traditional Chinese medicine(TCM)modalities,especially Chinese herbs,have accumulated rich experience in successfully treating sore throats in both acute and chronic pharyngitis.By sharing a real-world case study of three patients suffering pharyngeal discomfort including sore throat that might be related to the new coronavirus infection and have similar manifestations to general viral-induced pharyngitis,the article systematically presents and summarizes key Chinese herbsfor acute and chronic pharyngitis based on TCM herbal prescriptions(principles of herbal formula writing)below:clearing heat and removing toxins,nourishing yin and the throat,loosening the stools and soothing the throat,along withTCM syndrome differentiation ordisease differentiation andtreatment.Moreover,a modern interpretation of these principles in terms of the relationship between Shanghuo and Fire Rising,which may often be characterized by local redness,swelling,fever,and pain in the mouth or throat along with possible inflammation,and the correspondence between the pharynx and the anus are proposed.Finally,the article will share their experience in applying specific herbs locally via various pharyngeal deliverymodalities to improve efficacy including recommended prescriptions fora variety of acute and chronic pharyngitis,as well as those that may be caused by the new coronavirus infection. 展开更多
关键词 COVID-19 PHARYNGITIS sorethroat Chinese herbs omicron variant TCM
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从干针崛起看古典针灸传承与创新的必要性 被引量:1
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作者 金观源 金雷 +1 位作者 何洁 金霞 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2024年第1期1-8,共8页
By reviewing the historical background and the current state of dry needling(DN),including the"AntiDN Independence"movement by the acupuncture profession in the west,this paper emphasizes that DN is acupunct... By reviewing the historical background and the current state of dry needling(DN),including the"AntiDN Independence"movement by the acupuncture profession in the west,this paper emphasizes that DN is acupuncture,or more precisely,a"de-meridian"style of acupuncture.Clinical applications of DN and its modern studies have seen a tremendous growth spurt during the past two decades,which suggests that the meridian theory of traditional Chinese medicine(TCM)may not be the exclusive theory to guide acupuncture.Even certain high-quality DN trials may serve as good examples for acupuncture research,such as refining the stimulation targets in acupoints,recognizing the reflex properties of acupoints known as acu-reflex points(ARPs),or establishing standardized indicators of stimulus amount while objectively assessing the needling efficacy.Like any other therapies,DN has its shares of drawbacks or limitations,which reminds that while innovating classical acupuncture,it is still necessary to inherit the valuable experience of classic acupuncture and the rational core of meridian theory.This is crucial for enhancing the efficacy of clinical acupuncture intervention including DN to broaden the treatment scope and indications of acupuncture. 展开更多
关键词 Dry needling(DN) De-meridian Classical acupuncture Modern acupuncture INHERITANCE Innovation Acu-reflex points(ARPs)
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