Activation of neocortical 5 hydroxytryptamine 2A (5-HT 2A ) receptors is thought to mediate the profoud psychominetic effects of hallucinogenic drugs such as lysergic acid diethylamide(LSD).Coversely, blockade of neoc...Activation of neocortical 5 hydroxytryptamine 2A (5-HT 2A ) receptors is thought to mediate the profoud psychominetic effects of hallucinogenic drugs such as lysergic acid diethylamide(LSD).Coversely, blockade of neocortical 5-HT 2A receptor may be related to the thymoleptic effects of newly released antidepressant especially atypical antipsychotic drugs. Electrophsiological experiments using in vitro rat slices of the medial prefrontal cortex has found that activation of 5-HT 2A receptors results in glutamate release from thalamocortical terminals.In addition to activation of 5-HT 2A receptors, metabotropic glutamate (mGluR),and neuropeptide (μ-opioid) receptors suppress this release of glutamate that is induced by 5-HT 2A receptor activation. Recent clinical reports have found clear structural change in the prefrontal cortex of depressed patients. Furthermore, a number of post-mortem studies of suicides from different laboratories have found an increased number of 5-HT 2A binding sites in certain regions of the prefrontal cortex. Thus,understanding the effects of 5-HT 2A receptor activation in prefrontal cortex is likely to be relevant for the development of antidepressant drugs.展开更多
目的:评价抑郁症行为激活量表中文版(the Chinese version of behavioral activation for depression scale,C-BADS)应用于美沙酮维持治疗(methadone maintenance treatment,MMT)患者的信度和效度。方法:在武汉市MMT门诊随机招募162例...目的:评价抑郁症行为激活量表中文版(the Chinese version of behavioral activation for depression scale,C-BADS)应用于美沙酮维持治疗(methadone maintenance treatment,MMT)患者的信度和效度。方法:在武汉市MMT门诊随机招募162例阿片类物质成瘾患者接受C-BADS量表调查,采用SPSS 21.0软件进行项目分析和探索性因子分析(exploratory factors analysis,EFA),AMOS 24.0软件进行验证性因子分析(confirmatory factor analysis,CFA)。结果:各维度与总分之间的相关系数为0.228~0.813(均P<0.01),除激活维度外,其余各维度间的相关系数均低于各维度与总分之间的相关系数。各条目与总分之间的相关系数为0.060~0.716。探索性因子分析提取了4个公因子,分别命名为回避/沉思(avoidance/rumination,AR)、激活(activation,AC)、社会功能减退(social impairment,SI)和工作/学习功能减退(work/school impairment,WS),对总方差的累积贡献率为51.153%,各条目在所属因子上的因子负荷为0.328~0.797。验证性因子分析模型的整体拟合度指标为:χ^(2)/df=1.594,CFI=0.839,TLI=0.820,IFI=0.844,RMSEA=0.069,SRMR=0.089。量表内部一致性信度Cronbach'sα系数为0.790,分半信度为0.827。结论:C-BADS用于测量MMT患者行为激活状况具有较好的内部一致性信度和结构效度,但仍需要进一步修改。展开更多
文摘Activation of neocortical 5 hydroxytryptamine 2A (5-HT 2A ) receptors is thought to mediate the profoud psychominetic effects of hallucinogenic drugs such as lysergic acid diethylamide(LSD).Coversely, blockade of neocortical 5-HT 2A receptor may be related to the thymoleptic effects of newly released antidepressant especially atypical antipsychotic drugs. Electrophsiological experiments using in vitro rat slices of the medial prefrontal cortex has found that activation of 5-HT 2A receptors results in glutamate release from thalamocortical terminals.In addition to activation of 5-HT 2A receptors, metabotropic glutamate (mGluR),and neuropeptide (μ-opioid) receptors suppress this release of glutamate that is induced by 5-HT 2A receptor activation. Recent clinical reports have found clear structural change in the prefrontal cortex of depressed patients. Furthermore, a number of post-mortem studies of suicides from different laboratories have found an increased number of 5-HT 2A binding sites in certain regions of the prefrontal cortex. Thus,understanding the effects of 5-HT 2A receptor activation in prefrontal cortex is likely to be relevant for the development of antidepressant drugs.
文摘目的:评价抑郁症行为激活量表中文版(the Chinese version of behavioral activation for depression scale,C-BADS)应用于美沙酮维持治疗(methadone maintenance treatment,MMT)患者的信度和效度。方法:在武汉市MMT门诊随机招募162例阿片类物质成瘾患者接受C-BADS量表调查,采用SPSS 21.0软件进行项目分析和探索性因子分析(exploratory factors analysis,EFA),AMOS 24.0软件进行验证性因子分析(confirmatory factor analysis,CFA)。结果:各维度与总分之间的相关系数为0.228~0.813(均P<0.01),除激活维度外,其余各维度间的相关系数均低于各维度与总分之间的相关系数。各条目与总分之间的相关系数为0.060~0.716。探索性因子分析提取了4个公因子,分别命名为回避/沉思(avoidance/rumination,AR)、激活(activation,AC)、社会功能减退(social impairment,SI)和工作/学习功能减退(work/school impairment,WS),对总方差的累积贡献率为51.153%,各条目在所属因子上的因子负荷为0.328~0.797。验证性因子分析模型的整体拟合度指标为:χ^(2)/df=1.594,CFI=0.839,TLI=0.820,IFI=0.844,RMSEA=0.069,SRMR=0.089。量表内部一致性信度Cronbach'sα系数为0.790,分半信度为0.827。结论:C-BADS用于测量MMT患者行为激活状况具有较好的内部一致性信度和结构效度,但仍需要进一步修改。
