Hyperuricemia(HUA)is a metabolic disease caused by excessive production of serum uric acid(s UA)or decreased excretion of s UA in the body.HUA is an independent risk factor for chronic kidney disease,hypertension,card...Hyperuricemia(HUA)is a metabolic disease caused by excessive production of serum uric acid(s UA)or decreased excretion of s UA in the body.HUA is an independent risk factor for chronic kidney disease,hypertension,cardiovascular and cerebrovascular diseases,and diabetes mellitus.Timely and effective treatment for reducing s UA plays a key role in reducing urate deposition,preventing gout attacks,and reducing kidney damage and the occurrence of other accompanying diseases.Four pharmacological methods can be used to treat HUA:decrease urate production,increase urate excretion,prevent urate formation,and catabolize urate.To provide a reference for clinical treatment and new medical research for HUA,the drugs and potential drugs for HUA were reviewed in the present work.展开更多
In the present study, we aimed to investigate the effects of key extraction parameters including extraction time（10–20 min）, extraction temperature（30–60 °C）, ultrasonic power（60–90 W） and solvent-to-so...In the present study, we aimed to investigate the effects of key extraction parameters including extraction time（10–20 min）, extraction temperature（30–60 °C）, ultrasonic power（60–90 W） and solvent-to-solid（S/S） ratio（10–30 m L/g） on yield of celastrol from Celastrus monospermus Roxb. To optimize the conditions, we investigated the effects of parameters on the ultrasound assisted extraction（UAE） with the Box-Behnken Design（BBD）, one widely used form of Response Surface Methodology（RSM）. In all tested solvents, ethanol was the most effective for celastrol extraction, followed by methanol, ethanol, ethyl acetate, n-butanol and water. A second order polynomial model was fitted well to the extraction experimental data with R2 of 0.9928. Extraction yield of 3.116 mg/g was obtained for celastrol under the optimized extraction conditions of extraction time（20 min）, extraction temperature（46 °C）, ultrasonic power（60 W） and S/S ratio（30 m L/g）. Experimental validation was performed, and the experimental values agreed well with the predicted values. The results indicated that the UAE was good extraction material for celastrol from C. monospermus Roxb.展开更多
基金Jingmen Leading Science and Technology Project(Grant No.2020YDKY030)。
文摘Hyperuricemia(HUA)is a metabolic disease caused by excessive production of serum uric acid(s UA)or decreased excretion of s UA in the body.HUA is an independent risk factor for chronic kidney disease,hypertension,cardiovascular and cerebrovascular diseases,and diabetes mellitus.Timely and effective treatment for reducing s UA plays a key role in reducing urate deposition,preventing gout attacks,and reducing kidney damage and the occurrence of other accompanying diseases.Four pharmacological methods can be used to treat HUA:decrease urate production,increase urate excretion,prevent urate formation,and catabolize urate.To provide a reference for clinical treatment and new medical research for HUA,the drugs and potential drugs for HUA were reviewed in the present work.
文摘In the present study, we aimed to investigate the effects of key extraction parameters including extraction time（10–20 min）, extraction temperature（30–60 °C）, ultrasonic power（60–90 W） and solvent-to-solid（S/S） ratio（10–30 m L/g） on yield of celastrol from Celastrus monospermus Roxb. To optimize the conditions, we investigated the effects of parameters on the ultrasound assisted extraction（UAE） with the Box-Behnken Design（BBD）, one widely used form of Response Surface Methodology（RSM）. In all tested solvents, ethanol was the most effective for celastrol extraction, followed by methanol, ethanol, ethyl acetate, n-butanol and water. A second order polynomial model was fitted well to the extraction experimental data with R2 of 0.9928. Extraction yield of 3.116 mg/g was obtained for celastrol under the optimized extraction conditions of extraction time（20 min）, extraction temperature（46 °C）, ultrasonic power（60 W） and S/S ratio（30 m L/g）. Experimental validation was performed, and the experimental values agreed well with the predicted values. The results indicated that the UAE was good extraction material for celastrol from C. monospermus Roxb.
