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氨甲喋呤致口腔粘膜损伤动物模型的建立 被引量:5
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作者 钟大平 张翼军 《中国药科大学学报》 CAS CSCD 北大核心 2004年第1期92-94,共3页
AIM:To explore the model of methotrexate(MTX)-induced mic e oral mucosa lesions METHOD:A total of 282 mice were randomly d ivided into seven groups as follows:control,MTX10,20,30,40,50,75 mg/ml The physiological salin... AIM:To explore the model of methotrexate(MTX)-induced mic e oral mucosa lesions METHOD:A total of 282 mice were randomly d ivided into seven groups as follows:control,MTX10,20,30,40,50,75 mg/ml The physiological saline solution (05 ml) was ip injecte d into mice in control group The dose of MTX (05 ml) was ip injected int o mic e in other groups only once During 10 consecutive days after administration of MTX,3 mice were sacrificed in each day in all the groups and the patholog ical chang es of oral mucosa were examed under the optical microscope RE SULT: The incidence(45%~63%) and the integral rate(194%~56%) of mice ora l mu cosa lesions in group of intermediate-dose MTX (IDMTX) (20~40 mg/kg) were sign ifi cantly higher than those in other groups The death rate (not more than 5%) in group of IDMTX was lower than that in other groups CONCLUSION:As a result of induction of higher lesion rate and lower death rate of mice oral mucosa by IDMTX (2 0~40 mg/kg),the model of IDMTX-induced oral mucosa lesion could be applie d into clinical or basic 展开更多
关键词 氨甲喋呤 口腔粘膜损伤 动物模型 小鼠
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实体瘤迭合白血病六例 被引量:6
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作者 张红宾 张翼军 张勇 《临床血液学杂志》 CAS 1999年第4期163-164,共2页
关键词 实体瘤 白血病 合并症 迭合病因
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碱性成纤维细胞生长因子治疗化疗后口腔溃疡 被引量:19
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作者 张红宾 张翼军 《临床血液学杂志》 2000年第1期33-34,共2页
关键词 口腔溃疡 生长因子 治疗 化疗后
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迪康立舒防治化疗后恶心呕吐的观察与护理 被引量:1
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作者 靳彦 姜明杰 《齐齐哈尔医学院学报》 2002年第10期1157-1157,共1页
关键词 迪康立舒 化疗 恶性 呕吐 预防 治疗 护理 并发症
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