重症肺炎患者血清APC,IL-18的表达及其与临床预后的相关性

目的:探究重症肺炎患者血清APC,IL-18的表达及其与临床预后的相关性。方法:选取2022年1月~2024年1月我院收治的76例重症肺炎患者作为研究组,选择同期的76名到我院进行体检的健康人员作为对照组,全部研究对象均接受血清APC,IL-18指标的检测。结果:研究组的血清APC水平更低(P Objective: To investigate the expression of serum APC and IL-18 in patients with severe pneumonia and their correlation with clinical prognosis. Method: 76 severe pneumonia patients admitted to our hospital from January 2022 to January 2024 were selected as the study group, and 76 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group. All study subjects underwent serum APC and IL-18 index detection. Result: The serum APC level in the study group was lower (P < 0.05), and the IL-18 level in the study group was higher (P < 0.05);The regression analysis results showed that the levels of serum IL-18 and APC were related to the clinical prognosis of patients with severe pneumonia (P < 0.05);There is a significant positive correlation (P < 0.05) between different prognostic outcomes and serum IL-18 levels, and a significant negative correlation (P < 0.05) between different prognostic outcomes and serum APC levels. Conclusion: Compared with healthy individuals, patients with severe pneumonia show significant changes in serum APC and IL-18 indicators, which also have a significant impact on the prognosis of severe pneumonia patients, providing important reference for subsequent clinical diagnosis and treatment.

冠状动脉旁路移植术后低心排的危险因素

目的:探讨冠状动脉旁路移植(CABG)术后低心排的危险因素。方法:采用病例对照研究,以宜昌市第一人民医院重症医学科2008年1月～2012年9月CABG术后临床资料完整的全部病例(92例)患者为研究对象,低心排[诊断标准:多巴胺用量>10μg/(kg·min)]者为病例组(n=13),以无低心排患者对照组(n=79)。对两组患者潜在的危险因素进行对比分析,并采用非条件logistic多元回归分析判断影响CABG术后低心排的独立危险因素。结果:单因素分析结果显示:年龄、性别、术前近期心肌梗死(MI)、心律失常、术后呼吸衰竭、术前贫血为CABG术后低心排的危险因素。logistic多因素回归分析显示,CABG术后低心排的独立的危险因素是:术前近期MI OR18.149,95.0%CI[1.949-169.011];心律失常OR 30.509,95.0%CI[2.607-357.028];女性OR 10.743,95.0%CI[1.347-85.659](P<0.05,P<0.01)。结论:术前近期MI;心律失常是CABG术后低心排的独立的危险因素。