随着精准医学和人工智能的迅速发展,对心脏相关疾病的研究也日益深入,关于心脏的评估已从早期的解剖结构检查逐渐转向心肌功能和活性的评价。长期生活在高海拔地区低氧环境下易导致心肌损伤,严重情况甚至可引发高原性心脏病(high altitu...随着精准医学和人工智能的迅速发展,对心脏相关疾病的研究也日益深入,关于心脏的评估已从早期的解剖结构检查逐渐转向心肌功能和活性的评价。长期生活在高海拔地区低氧环境下易导致心肌损伤,严重情况甚至可引发高原性心脏病(high altitude heart disease, HAHD)。早期心肌损伤目前比较难以诊断,且预后较差,因此及时进行诊断和治疗对高海拔地区居民的健康至关重要。心脏磁共振成像(cardiac magnetic resonance imaging, CMR)能敏感地检测出高海拔地区心肌早期结构和功能的变化,可为临床提供早期诊断和治疗的科学依据,同时在心脏相关疾病疗效监测、用药指导和预后判断等方面发挥着重要作用。本研究对高海拔地区心脏早期损伤的临床特点、损伤机制、心脏磁共振评价方法以及临床意义进行综述。Research on heart-related disorders has become more thorough as precision medicine and artificial intelligence have advanced quickly. Assessment of myocardial function and activity has gradually replaced early anatomical structure testing in the evaluation of the heart. Living in low oxygen settings for an extended period of time at high altitudes can easily cause cardiac damage. In extreme circumstances, it may result high altitude heart disease (HAHD). For the health of people living in high-altitude regions, prompt diagnosis and treatment are essential because early myocardial damage is currently difficult to diagnose and has a bad prognosis. In high-altitude environments, cardiac magnetic resonance imaging (CMRI) can accurately identify early alterations in the structure and function of the heart, offering a scientific foundation for prompt diagnosis and treatment in clinical settings. It is also crucial for prognosis prediction, drug guidance, and evaluating the effectiveness of heart-related conditions. The clinical features, mechanisms of injury, techniques for evaluating cardiac magnetic resonance imaging, and clinical importance of early heart injury in high-altitude regions are reviewed in this paper.展开更多
目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光...目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光探针法检测HBV-DNA、全自动生化分析仪测定ALT;Mann-Whitney U test用于两分组样本之间的比较,Kruskal-Wallis H分析多组非参数连续数据,两变量间的相关性采用Spearman等级相关分析,计数资料用卡方检验,P<0.05为差异有统计学意义。结果:①藏族HBsAg阳性者男性多于女性(1.3:1)且主要分布在11∼60岁,平均年龄(37.16±14.38)岁;②HBV-M组合模式共有7种,以小三阳(42.7%)和大三阳(38.5%)为主,且大三阳模式的HBV-DNA与ALT异常率均显著高于小三阳(P<0.001);③藏族HBsAg阳性者的HBV-DNA载量与ALT水平呈正相关(rs=0.244,P<0.001)、与年龄呈负相关(rs=-0.223,P<0.001);④HBsAg阳性者中不同性别间ALT有统计学意义(P<0.001),而HBVDNA载量间无统计学意义(P>0.05);⑤HBeAg(+)与(-)两组间HBV-DNA、ALT的差异均有统计学意义(P<0.001)。结论:本研究发现的7种HBV-M模式中主要为小三阳、大三阳,HBeAg阳性者的病毒复制水平和ALT异常率最高;HBV-DNA载量与不同的HBV-M模式、年龄以及ALT异常有关,与性别无关。展开更多
文摘随着精准医学和人工智能的迅速发展,对心脏相关疾病的研究也日益深入,关于心脏的评估已从早期的解剖结构检查逐渐转向心肌功能和活性的评价。长期生活在高海拔地区低氧环境下易导致心肌损伤,严重情况甚至可引发高原性心脏病(high altitude heart disease, HAHD)。早期心肌损伤目前比较难以诊断,且预后较差,因此及时进行诊断和治疗对高海拔地区居民的健康至关重要。心脏磁共振成像(cardiac magnetic resonance imaging, CMR)能敏感地检测出高海拔地区心肌早期结构和功能的变化,可为临床提供早期诊断和治疗的科学依据,同时在心脏相关疾病疗效监测、用药指导和预后判断等方面发挥着重要作用。本研究对高海拔地区心脏早期损伤的临床特点、损伤机制、心脏磁共振评价方法以及临床意义进行综述。Research on heart-related disorders has become more thorough as precision medicine and artificial intelligence have advanced quickly. Assessment of myocardial function and activity has gradually replaced early anatomical structure testing in the evaluation of the heart. Living in low oxygen settings for an extended period of time at high altitudes can easily cause cardiac damage. In extreme circumstances, it may result high altitude heart disease (HAHD). For the health of people living in high-altitude regions, prompt diagnosis and treatment are essential because early myocardial damage is currently difficult to diagnose and has a bad prognosis. In high-altitude environments, cardiac magnetic resonance imaging (CMRI) can accurately identify early alterations in the structure and function of the heart, offering a scientific foundation for prompt diagnosis and treatment in clinical settings. It is also crucial for prognosis prediction, drug guidance, and evaluating the effectiveness of heart-related conditions. The clinical features, mechanisms of injury, techniques for evaluating cardiac magnetic resonance imaging, and clinical importance of early heart injury in high-altitude regions are reviewed in this paper.
文摘目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光探针法检测HBV-DNA、全自动生化分析仪测定ALT;Mann-Whitney U test用于两分组样本之间的比较,Kruskal-Wallis H分析多组非参数连续数据,两变量间的相关性采用Spearman等级相关分析,计数资料用卡方检验,P<0.05为差异有统计学意义。结果:①藏族HBsAg阳性者男性多于女性(1.3:1)且主要分布在11∼60岁,平均年龄(37.16±14.38)岁;②HBV-M组合模式共有7种,以小三阳(42.7%)和大三阳(38.5%)为主,且大三阳模式的HBV-DNA与ALT异常率均显著高于小三阳(P<0.001);③藏族HBsAg阳性者的HBV-DNA载量与ALT水平呈正相关(rs=0.244,P<0.001)、与年龄呈负相关(rs=-0.223,P<0.001);④HBsAg阳性者中不同性别间ALT有统计学意义(P<0.001),而HBVDNA载量间无统计学意义(P>0.05);⑤HBeAg(+)与(-)两组间HBV-DNA、ALT的差异均有统计学意义(P<0.001)。结论:本研究发现的7种HBV-M模式中主要为小三阳、大三阳,HBeAg阳性者的病毒复制水平和ALT异常率最高;HBV-DNA载量与不同的HBV-M模式、年龄以及ALT异常有关,与性别无关。
