慢性创面是全球医疗保健系统的社会负担,也是患者的经济负担,严重影响了他们的生活质量。老年人和糖尿病患者等易感人群的迅速增长,使慢性创面的发生率一直在稳步上升。慢性创面的特点是伤口愈合过程延迟,在标准护理下愈合比急性(即健康...慢性创面是全球医疗保健系统的社会负担,也是患者的经济负担,严重影响了他们的生活质量。老年人和糖尿病患者等易感人群的迅速增长,使慢性创面的发生率一直在稳步上升。慢性创面的特点是伤口愈合过程延迟,在标准护理下愈合比急性(即健康)创面需要更长的时间。由于感染的参与和严重程度,慢性创面的愈合一直是令人担忧的问题。生物材料在慢性创面管理中的功能和作用已经得到普遍认可,这种生物材料之一是胶原蛋白,胶原蛋白作为伤口敷料中最常用的材料之一,因为它有助于模仿本地伤口微环境,它被认为是大多数用于创面愈合配方的关键成分。传统的胶原蛋白从陆地动物中提取出来,它存在宗教限制,也存在疾病传播的风险;而鱼皮胶原蛋白从海洋生物中提取出来,因其具有独特的结构和功能特性,使其成为细胞附着、生长和分化的天然基质。鱼皮胶原蛋白不仅可以促进皮肤上皮化、血管化、成纤维细胞迁移,还能整体加快创面愈合的能力,未来将成为一种潜在的更有前途的新型材料分子。本文我们介绍了用于慢性创面愈合的鱼皮胶原蛋白的最新研究进展。旨在为进一步研究提供新的观点。Chronic wounds are a social burden on the global healthcare system and an economic burden on patients, seriously affecting their quality of life. The rapid growth of susceptible populations such as the elderly and diabetes patients has led to a steady increase in the incidence of chronic wounds. The characteristic of chronic wounds is delayed wound healing process, which takes longer to heal under standard care than acute (i.e. healthy) wounds. The healing of chronic wounds has always been a concern due to the involvement and severity of infections. The function and role of biomaterials in chronic wound management have been widely recognized. One of these biomaterials is collagen, which is one of the most commonly used materials in wound dressings because it helps mimic the local wound microenvironment. It is considered a key ingredient in most wound healing formulas. Traditional collagen is extracted from terrestrial animals, which has religious restrictions and the risk of disease transmission;Fish skin collagen is extracted from marine organisms and has unique structural and functional properties, making it a natural matrix for cell attachment, growth, and differentiation. Fish skin collagen can not only promote skin epithelialization, vascularization, and fibroblast migration, but also accelerate the overall ability of wound healing. In the future, it will become a potential and more promising new material molecule. In this article, we introduce the latest research progress on fish skin collagen used for chronic wound healing. Intended to provide new perspectives for further research.展开更多
糖尿病可导致多种并发症,由于高血糖、高水平的氧化应激和炎症以及易受感染等不利因素导致糖尿病慢性伤口难以愈合甚至恶化。如糖尿病足、糖尿病溃疡创面等这是糖尿病患者死亡的重要原因之一。与正常伤口相比,糖尿病创面难愈合的因素最...糖尿病可导致多种并发症,由于高血糖、高水平的氧化应激和炎症以及易受感染等不利因素导致糖尿病慢性伤口难以愈合甚至恶化。如糖尿病足、糖尿病溃疡创面等这是糖尿病患者死亡的重要原因之一。与正常伤口相比,糖尿病创面难愈合的因素最重要的是巨噬细胞的活化失调,M1不能及时转化为M2,炎症期延长,炎症因子过度表达,阻碍转化成M2抗炎的状态,降低抗炎因子的活性,这就使得糖尿病创面炎症表达过高,不能通过自愈能让创面愈合。目前水凝胶已成为伤口敷料研究的热点材料。水凝胶能提供一个最佳的伤口水分水平的控制,因为它能够吸收多余的液体从伤口或释放水分的需要。水凝胶由于含水量高、生物相容性好、传递药物等优点,与纱布等传统敷料相比,水凝胶敷料可以提供有利于伤口愈合的湿润环境。水凝胶敷料还具有优异的组织粘附、抗菌能力、抗氧化和炎症调节作用等,在伤口敷料中具有广阔的前景。本文基于水凝胶材料的特点和糖尿病慢性创面的微环境,总结了近年来新型抗炎性水凝胶敷料治疗糖尿病慢性创面的研究进展,并探讨了目前水凝胶敷料的缺点和展望,让糖尿病伤口的个性化管理和治疗成为可能。Diabetes can lead to a variety of complications, due to high blood sugar, high levels of oxidative stress and inflammation, as well as susceptibility to infection and other. adverse factors that make diabetic chronic wounds difficult to heal or even worsen. Such as chronic wounds, diabetic feet, diabetic ulcer wounds, etc. This is one of the important causes of death in diabetic patients. Compared with normal wounds, the most important factor that makes diabetic wounds difficult to heal is the dysactivation of macrophages, M1 cannot be converted into M2 in time, and the overexpression of inflammatory factors prevents the transformation into anti-inflammatory factors. As a result, the inflammatory expression of diabetic wounds is too high, and the wound cannot be healed through self-healing. At present, hydrogels have become a hot material in wound dressing research. Compared with traditional dressings such as gauze, hydrogel dressings can provide a moist environment conducive to wound healing due to their high water content, good biocompatibility and drug delivery. Hydrogel dressings also have excellent tissue adhesion, antibacterial ability, anti-oxidation and inflammation regulation, etc., and have broad prospects in wound dressings. Based on the characteristics of hydrogel materials and the microenvironment of diabetic chronic wounds, this paper summarizes the research progress of new anti-inflammatory hydrogel dressings for the treatment of diabetic chronic wounds in recent years, and discusses the shortcomings and prospects of current hydrogel dressings, so as to make personalized management and treatment of diabetic wounds possible.展开更多
文摘慢性创面是全球医疗保健系统的社会负担,也是患者的经济负担,严重影响了他们的生活质量。老年人和糖尿病患者等易感人群的迅速增长,使慢性创面的发生率一直在稳步上升。慢性创面的特点是伤口愈合过程延迟,在标准护理下愈合比急性(即健康)创面需要更长的时间。由于感染的参与和严重程度,慢性创面的愈合一直是令人担忧的问题。生物材料在慢性创面管理中的功能和作用已经得到普遍认可,这种生物材料之一是胶原蛋白,胶原蛋白作为伤口敷料中最常用的材料之一,因为它有助于模仿本地伤口微环境,它被认为是大多数用于创面愈合配方的关键成分。传统的胶原蛋白从陆地动物中提取出来,它存在宗教限制,也存在疾病传播的风险;而鱼皮胶原蛋白从海洋生物中提取出来,因其具有独特的结构和功能特性,使其成为细胞附着、生长和分化的天然基质。鱼皮胶原蛋白不仅可以促进皮肤上皮化、血管化、成纤维细胞迁移,还能整体加快创面愈合的能力,未来将成为一种潜在的更有前途的新型材料分子。本文我们介绍了用于慢性创面愈合的鱼皮胶原蛋白的最新研究进展。旨在为进一步研究提供新的观点。Chronic wounds are a social burden on the global healthcare system and an economic burden on patients, seriously affecting their quality of life. The rapid growth of susceptible populations such as the elderly and diabetes patients has led to a steady increase in the incidence of chronic wounds. The characteristic of chronic wounds is delayed wound healing process, which takes longer to heal under standard care than acute (i.e. healthy) wounds. The healing of chronic wounds has always been a concern due to the involvement and severity of infections. The function and role of biomaterials in chronic wound management have been widely recognized. One of these biomaterials is collagen, which is one of the most commonly used materials in wound dressings because it helps mimic the local wound microenvironment. It is considered a key ingredient in most wound healing formulas. Traditional collagen is extracted from terrestrial animals, which has religious restrictions and the risk of disease transmission;Fish skin collagen is extracted from marine organisms and has unique structural and functional properties, making it a natural matrix for cell attachment, growth, and differentiation. Fish skin collagen can not only promote skin epithelialization, vascularization, and fibroblast migration, but also accelerate the overall ability of wound healing. In the future, it will become a potential and more promising new material molecule. In this article, we introduce the latest research progress on fish skin collagen used for chronic wound healing. Intended to provide new perspectives for further research.
文摘糖尿病可导致多种并发症,由于高血糖、高水平的氧化应激和炎症以及易受感染等不利因素导致糖尿病慢性伤口难以愈合甚至恶化。如糖尿病足、糖尿病溃疡创面等这是糖尿病患者死亡的重要原因之一。与正常伤口相比,糖尿病创面难愈合的因素最重要的是巨噬细胞的活化失调,M1不能及时转化为M2,炎症期延长,炎症因子过度表达,阻碍转化成M2抗炎的状态,降低抗炎因子的活性,这就使得糖尿病创面炎症表达过高,不能通过自愈能让创面愈合。目前水凝胶已成为伤口敷料研究的热点材料。水凝胶能提供一个最佳的伤口水分水平的控制,因为它能够吸收多余的液体从伤口或释放水分的需要。水凝胶由于含水量高、生物相容性好、传递药物等优点,与纱布等传统敷料相比,水凝胶敷料可以提供有利于伤口愈合的湿润环境。水凝胶敷料还具有优异的组织粘附、抗菌能力、抗氧化和炎症调节作用等,在伤口敷料中具有广阔的前景。本文基于水凝胶材料的特点和糖尿病慢性创面的微环境,总结了近年来新型抗炎性水凝胶敷料治疗糖尿病慢性创面的研究进展,并探讨了目前水凝胶敷料的缺点和展望,让糖尿病伤口的个性化管理和治疗成为可能。Diabetes can lead to a variety of complications, due to high blood sugar, high levels of oxidative stress and inflammation, as well as susceptibility to infection and other. adverse factors that make diabetic chronic wounds difficult to heal or even worsen. Such as chronic wounds, diabetic feet, diabetic ulcer wounds, etc. This is one of the important causes of death in diabetic patients. Compared with normal wounds, the most important factor that makes diabetic wounds difficult to heal is the dysactivation of macrophages, M1 cannot be converted into M2 in time, and the overexpression of inflammatory factors prevents the transformation into anti-inflammatory factors. As a result, the inflammatory expression of diabetic wounds is too high, and the wound cannot be healed through self-healing. At present, hydrogels have become a hot material in wound dressing research. Compared with traditional dressings such as gauze, hydrogel dressings can provide a moist environment conducive to wound healing due to their high water content, good biocompatibility and drug delivery. Hydrogel dressings also have excellent tissue adhesion, antibacterial ability, anti-oxidation and inflammation regulation, etc., and have broad prospects in wound dressings. Based on the characteristics of hydrogel materials and the microenvironment of diabetic chronic wounds, this paper summarizes the research progress of new anti-inflammatory hydrogel dressings for the treatment of diabetic chronic wounds in recent years, and discusses the shortcomings and prospects of current hydrogel dressings, so as to make personalized management and treatment of diabetic wounds possible.
