单层芯渗透泵片用于水不溶性药物的控制释放

Aim To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Methods Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Results Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Conclusion Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.

夹芯渗透泵片用于水不溶性药物的控制释放

目的 研究夹芯渗透泵片用于水不溶性药物的 2 4h控制释放。方法 以硝苯吡啶为模型药物 ,制备夹芯渗透泵片 ,研究处方、释药孔径等因素对夹芯渗透泵片释药规律的影响 ,并考察包衣的机械性质。结果 药物层中聚氧乙烯和膨胀层中氯化钾对释药的正面影响最大。在 0 5 0～ 1 4 0mm ,孔径对释药影响不大。醋酸纤维素包衣牢固可靠 ,能承受 0 34～ 2 85MPa的内压。结论 夹芯渗透泵片能 2 4h匀速释放水不溶性药物。环境介质和搅拌对释药的影响不大。与市售双层渗透泵片相比 ,夹芯渗透泵片免去了打孔前的药物层辨认过程 ,制备过程简化。