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中医外治法治疗黄褐斑的研究现状
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作者 石灿 唐毅博 马天明 《临床医学进展》 2024年第11期1121-1126,共6页
黄褐斑,亦称“黧黑斑”,属于中医学“面尘”的范畴,是种常见的面部色素沉着性皮肤病。黄褐斑一般发展缓慢,持续多年且难以消退,发病率随着年龄增长而升高。由于该病发生在面部,随着人们对容貌的要求增高,黄褐斑对患者精神心理的影响也... 黄褐斑,亦称“黧黑斑”,属于中医学“面尘”的范畴,是种常见的面部色素沉着性皮肤病。黄褐斑一般发展缓慢,持续多年且难以消退,发病率随着年龄增长而升高。由于该病发生在面部,随着人们对容貌的要求增高,黄褐斑对患者精神心理的影响也愈加严重。黄褐斑病灶在皮肤,中医外治法可直达病所,且毒副作用相对较小、药物依赖性低。治疗方法包括中药面膜、面部刮痧、穴位埋线、揿针、火针等,并且以其临床有效率较高、副作用较小、治愈后复发率较低等特点,在黄褐斑的治疗过程中有着明显的优势。Chloasma, which is called “lathyrus black spot” in Chinese medicine, belongs to the category of “face dust” in traditional Chinese medicine, and is a common skin disease of facial pigmentation. Melasma generally develops slowly, lasts for many years, and is difficult to subside. Its incidence increases with age. As the disease occurs in the face, as people’s requirements for appearance increase, melasma on patients’ mental and psychological impact is more serious. The lesions of chloasma are in the skin, and traditional Chinese external treatments can directly reach the affected area, having relatively fewer side effects and lower drug dependency. Treatment methods include traditional Chinese medicine mask, facial Gua Sha, acupoint burying, acupuncture, fire acupuncture, etc., and with its high clinical efficiency, fewer side effects, and low recurrence rate after cure, it has obvious advantages in the treatment process of chloasma. 展开更多
关键词 黄褐斑 中医外治法
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益气活血方药对缺血性脑损伤保护作用的实验研究进展 被引量:7
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作者 张雨薇 刘宏 +3 位作者 张博 李炎 叶阳 黄树明 《中国医学装备》 2016年第1期122-126,共5页
缺血性脑血管病的发生与诸多因素相关,而中医则认为"气虚血瘀"为其主要病机之一。目前,临床治疗多以益气活血作为本类疾病的基本治疗原则,益气活血法在临床上被广泛用于脑缺血的治疗,并取得了显著效果。益气活血方药,因其成... 缺血性脑血管病的发生与诸多因素相关,而中医则认为"气虚血瘀"为其主要病机之一。目前,临床治疗多以益气活血作为本类疾病的基本治疗原则,益气活血法在临床上被广泛用于脑缺血的治疗,并取得了显著效果。益气活血方药,因其成分的复杂性,显示多层次、多环节及多靶点的作用优势。为此,综合论述近年来的相关文献,从保护神经元、促神经再生、改善能量代谢、降低兴奋毒性以及改善微循环等方面系统总结益气活血法防治缺血性脑血管病的作用机制,以期为临床应用提供现代药理学理论依据。 展开更多
关键词 益气活血 脑缺血 气虚血瘀
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复方血塞通滴丸的体内药物动力学研究 被引量:1
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作者 薛红梅 李若梅 王建明 《黑龙江科技信息》 2016年第27期24-25,共2页
目的:以三七皂苷R1、人参皂苷Rb1及人参皂苷Rg1为研究对象,考察灌胃给予大鼠复方血塞通滴丸的混悬液后的体内药动学过程,为临床合理用药提供依据。本研究以三七总皂苷粉对大鼠灌胃给药作平行对照试验,考察合并给予葛根与山楂对三七总皂... 目的:以三七皂苷R1、人参皂苷Rb1及人参皂苷Rg1为研究对象,考察灌胃给予大鼠复方血塞通滴丸的混悬液后的体内药动学过程,为临床合理用药提供依据。本研究以三七总皂苷粉对大鼠灌胃给药作平行对照试验,考察合并给予葛根与山楂对三七总皂苷在大鼠体内吸收的影响。方法:采用HPLC法测定血清中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的浓度,监测药时数据,用药动学软件进行数据处理。结果:三七皂苷R1和人参皂苷Rg1吸收较好,且出现双峰现象,经药动学拟合均属于一室模型,而人参皂苷Rb1在5-6h才检测到,且达峰浓度较低,经药动学拟合属于二室模型。结论:葛根和山楂中的有效成分对三七在体内的吸收有一定的促进作用。 展开更多
关键词 复方血塞通滴丸 三七皂苷R1 人参皂苷RB1 人参皂苷RG1 药物动力学
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骨质疏松症的治疗和研究进展 被引量:7
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作者 李健英 《黑龙江医药》 CAS 2009年第2期147-148,共2页
骨质疏松症(OP)是一种全身性的骨骼疾病,是一种增龄性病变,易于引发骨折为特征代谢性疾病,发病率跃居常见病、多发病的第7位。随着老年人口不断增加。已成为一个严重的社会问题而备受各国政府及老年学者的关注。据统计60-69岁老年... 骨质疏松症(OP)是一种全身性的骨骼疾病,是一种增龄性病变,易于引发骨折为特征代谢性疾病,发病率跃居常见病、多发病的第7位。随着老年人口不断增加。已成为一个严重的社会问题而备受各国政府及老年学者的关注。据统计60-69岁老年妇女骨质疏松发生率高达50%-70%,老年男性发生率为30%。随着老龄化社会的到来,OP的发生率逐年上升,据统计其发病率约占人口总数的十分之一。美国OP患者已达1000万人,并有约1800万人为可疑OP患者。 展开更多
关键词 骨质疏松 雌激素 降钙素
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益脑康宁滴丸定性定量方法的研究
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作者 王建明 赵志艳 刘相辉 《中国医药导刊》 2009年第1期152-154,共3页
目的:研究益脑康宁滴丸中主要药物的鉴别和含量测定方法。方法:采用TLC法鉴别主要药物;采用HPLC-ELSD法测定制剂中黄芪甲苷的含量;色谱条件:Kromasi1C18(200mm×4.6mm,5μm)色谱柱;以乙腈-水(32:68)为流动相;流速为1.0ml·min^(... 目的:研究益脑康宁滴丸中主要药物的鉴别和含量测定方法。方法:采用TLC法鉴别主要药物;采用HPLC-ELSD法测定制剂中黄芪甲苷的含量;色谱条件:Kromasi1C18(200mm×4.6mm,5μm)色谱柱;以乙腈-水(32:68)为流动相;流速为1.0ml·min^(-1);柱温为30℃结果:定性鉴别阴性对照无干扰,分离度高;黄芪甲苷在(2.10~6.30)μg范围内呈良好的线性关系,r=09999,平均加样回收率为99.64% , RSD为1.0%。结论:该实验所建立的鉴别方法专属性强,定量方法简便、准确、重现性好,可用于益脑康宁滴丸的质量控制。 展开更多
关键词 药物分析 TLC法 HPLC-ELSP法 益脑康宁滴丸 黄芪甲苷
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香叶木苷的药理作用研究新进展 被引量:4
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作者 孔晓悦 李聪慧 +3 位作者 张凯 邢绪东 吴伦 崔明宇 《黑龙江医药》 CAS 2017年第4期724-727,共4页
香叶木苷为黄酮类化合物,具有良好的增强静脉张力、改善微循环、促进淋巴回流、减轻水肿的作用,作为静脉疾病治疗药物取得了良好的临床疗效。近年来,有关香叶木苷的一些新的药理作用不断被发现,本文查阅近年来相关的国内外文献,并进行... 香叶木苷为黄酮类化合物,具有良好的增强静脉张力、改善微循环、促进淋巴回流、减轻水肿的作用,作为静脉疾病治疗药物取得了良好的临床疗效。近年来,有关香叶木苷的一些新的药理作用不断被发现,本文查阅近年来相关的国内外文献,并进行综合整理,对香叶木苷的新的药理研究进展进行综述,同时对后续临床应用做出展望。 展开更多
关键词 香叶木苷 药理作用
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丁香苦苷固体脂质纳米粒冻干粉的体外释放研究 被引量:4
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作者 张喜武 朱健 +3 位作者 李永吉 杨斯棋 张丽丽 窦金金 《现代中药研究与实践》 CAS 2020年第1期46-49,共4页
目的研究丁香苦苷固体脂质纳米粒(S-SLN)冻干粉的体外释放规律,为丁香苦苷体内药物释放行为提供重要参考。方法应用动态透析法,测定各时间点丁香苦苷累积释放率,绘制释放曲线,并将结果数据进行模型拟合。结果S-SLN冻干粉的体外释放规律... 目的研究丁香苦苷固体脂质纳米粒(S-SLN)冻干粉的体外释放规律,为丁香苦苷体内药物释放行为提供重要参考。方法应用动态透析法,测定各时间点丁香苦苷累积释放率,绘制释放曲线,并将结果数据进行模型拟合。结果S-SLN冻干粉的体外释放规律与Higuchi方程的释放模型基本一致,与丁香苦苷单体累积释放百分率比较,S-SLN冻干粉36 h的累积释放量与丁香苦苷单体4 h相近。结论S-SLN冻干粉的体外释放具有较好的缓控释及长效的作用。 展开更多
关键词 丁香苦苷 纳米粒 体外释放 冻干粉
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大黄硝石汤组成药物君臣配伍意义探析 被引量:5
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作者 孔祥鹏 裴妙荣 +1 位作者 邓亮 赵丽娜 《中成药》 CAS CSCD 北大核心 2014年第1期175-177,共3页
大黄硝石汤首载于张仲景《伤寒杂病论》,本文在总结历代本草著作中所含方中各味药药性的基础上,对其组方配伍意义进行阐释,为其临床合理使用及现代研究提供参考。
关键词 大黄硝石汤 本草 配伍
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二氢槲皮素对异丙肾上腺素所致急性心肌缺血大鼠心肌磷脂酰肌醇3-激酶/糖原合成酶激酶-3β信号通路的影响 被引量:3
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作者 吴明娟 费洪新 +2 位作者 田明 周忠光 韩玉生 《中国医药导报》 CAS 2020年第2期15-19,共5页
目的探讨二氢槲皮素对异丙肾上腺素所致的急性心肌缺血大鼠心肌磷脂酰肌醇3-激酶(PI3K)/糖原合成酶激酶-3β(GSK-3β)信号通路的影响。方法将60只清洁级SD大鼠按随机数字表法随机分为空白组,模型组,地奥心血康组(54 mg/kg),二氢槲皮素高... 目的探讨二氢槲皮素对异丙肾上腺素所致的急性心肌缺血大鼠心肌磷脂酰肌醇3-激酶(PI3K)/糖原合成酶激酶-3β(GSK-3β)信号通路的影响。方法将60只清洁级SD大鼠按随机数字表法随机分为空白组,模型组,地奥心血康组(54 mg/kg),二氢槲皮素高(60 mg/kg)、中(30 mg/kg)、低(15 mg/kg)剂量组,连续灌胃给药14 d,第12天开始异丙肾上腺素腹腔注射建立大鼠急性心肌缺血模型。检测各组大鼠血液流变学变化;测定各组大鼠血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)、一氧化氮(NO)水平,以及心肌组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)的水平;Western blot法检测心肌PI3K、磷酸化蛋白激酶B(PKB)和GSK-3β蛋白表达。结果与空白组比较,模型组大鼠全血黏度、血浆黏度、血细胞比容均明显升高(P<0.05),血清中LDH、CK水平明显增加(P<0.05),NO水平明显降低(P<0.05),心肌组织SOD、GSH-Px、CAT水平和PI3K蛋白表达明显降低(P<0.05),MDA水平和GSK-3β蛋白表达明显升高(P<0.05)。与模型组比较,二氢槲皮素高、中、低剂量组血浆黏度均降低(P<0.05),二氢槲皮素中、低剂量组血细胞比容明显降低(P<0.05),二氢槲皮素高、中剂量组血清中LDH、CK水平均明显降低(P<0.05),二氢槲皮素各剂量组NO水平明显升高(P<0.05),二氢槲皮素各剂量组大鼠心肌组织中SOD、GSH-Px、CAT水平和PI3K蛋白表达明显升高(P<0.05),MDA水平明显降低(P<0.05)。二氢槲皮素高、中剂量组GSK-3β蛋表达明显降低(P<0.05)。结论二氢槲皮素能通过调控PI3K/GSK-3β信号通路抑制氧化应激级联反应,调节心肌血流量,阻断心血缺血的进程,从而发挥抗心肌缺血的作用。 展开更多
关键词 二氢槲皮素 急性心肌缺血 磷脂酰肌醇3-激酶 糖原合成酶激酶-3Β
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颈夹脊穴在临床中常见的应用
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作者 戴国清 赵惠 《临床医学进展》 2023年第11期17105-17109,共5页
颈夹脊穴位于颈椎棘突下旁开0.5寸,膀胱经与督脉之间,两经均为阳经,气血与阳气充足,夹脊穴可提供充分阳气,具有舒筋活络、活血化瘀、祛风散寒的功效,常用于治疗颈部疾病:颈源性眩晕、神经根型颈椎病、椎动脉型颈椎病,脑血管疾病:血管性... 颈夹脊穴位于颈椎棘突下旁开0.5寸,膀胱经与督脉之间,两经均为阳经,气血与阳气充足,夹脊穴可提供充分阳气,具有舒筋活络、活血化瘀、祛风散寒的功效,常用于治疗颈部疾病:颈源性眩晕、神经根型颈椎病、椎动脉型颈椎病,脑血管疾病:血管性痴呆、脑梗死后吞咽困难、脑梗死后眩晕、短暂性脑缺血发作,其他各类疾病如过敏性鼻炎、周围性面瘫、颈椎间盘突出等临床常见疾病。 展开更多
关键词 颈夹脊穴
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黄连-黄芩及黄连-黄芩-黄柏干预2,4-二硝基苯酚诱导热病证候模型的代谢物组学研究 被引量:1
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作者 荆雷 何薇 +3 位作者 刘树民 黄志桓 刘东敏 祖金祥 《中药药理与临床》 CAS CSCD 北大核心 2011年第4期67-71,共5页
目的:基于代谢物组学理论,探讨黄连解毒汤的拆方黄连-黄芩及黄连-黄芩-黄柏干预2,4-二硝基苯酚诱导热病证候模型在代谢物组学层面上的关联性。方法:运用UPLC/MS技术手段,采用PCA和PLS-DA数据解析方法,研究黄连-黄芩及黄连-黄芩-黄柏对... 目的:基于代谢物组学理论,探讨黄连解毒汤的拆方黄连-黄芩及黄连-黄芩-黄柏干预2,4-二硝基苯酚诱导热病证候模型在代谢物组学层面上的关联性。方法:运用UPLC/MS技术手段,采用PCA和PLS-DA数据解析方法,研究黄连-黄芩及黄连-黄芩-黄柏对于热病证候模型大鼠尿液中生物标记物的影响。结果:初步确定2,4-二硝基苯酚诱导热病证候模型51个生物标志物,黄连-黄芩对于其中8个生物标志物具有明显干预作用,黄连-黄芩-黄柏对于其中15个生物标志物有明显干预作用。结论:黄连-黄芩-黄柏对于热病证候模型生物标志物的干预数量和程度均好于黄连-黄芩,佐药黄柏的加入有效加强了对热病的治疗作用,从代谢物组学的角度阐明了传统复方理论中"君臣佐使"组方原则的科学性。 展开更多
关键词 黄连-黄芩 黄连-黄芩-黄柏 2 4-二硝基苯酚 热病证候 代谢组学 生物标志物
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黄芪赤风汤对脑梗死大鼠模型的治疗作用及对脑组织ZO-1、Claudin-5、P-gp、MRP1蛋白表达的影响 被引量:11
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作者 刘舒毓 王秋月 刘树民 《中国实验方剂学杂志》 CAS CSCD 北大核心 2022年第6期26-33,共8页
目的:探究黄芪赤风汤对大脑中动脉栓塞(MCAO)大鼠模型的治疗作用及机制。方法:将90只SPF级雄性大鼠随机分为假手术组,模型组,黄芪赤风汤高、中、低剂量组(中药低、中、高剂量组)(8.10、4.05、2.025 g·kg^(-1)),脑心通组(脑心通,0.3... 目的:探究黄芪赤风汤对大脑中动脉栓塞(MCAO)大鼠模型的治疗作用及机制。方法:将90只SPF级雄性大鼠随机分为假手术组,模型组,黄芪赤风汤高、中、低剂量组(中药低、中、高剂量组)(8.10、4.05、2.025 g·kg^(-1)),脑心通组(脑心通,0.32 g·kg^(-1)),建立MCAO大鼠模型,给予黄芪赤风汤药液进行干预,对各组大鼠进行神经功能学评分;大鼠脑组织采用2,3,5-氯化三苯四氮唑(TTC)染色,计算脑梗死面积;采用酶联免疫吸附测定法(ELISA)检测各组大鼠血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)和血管内皮生长因子受体2(VEGFR2)含量;采用苏木素-伊红(HE)染色观察各组大鼠脑组织病理变化;蛋白免疫印迹法(Western blot)检测大鼠脑组织闭锁小带蛋白-1(ZO-1)、紧密连接蛋白-5(Claudin-5)、P-糖蛋白(P-gp)和多药耐药蛋白1(MRP1)的表达。结果:与假手术组比较,模型组大鼠神经功能评分、脑梗死率显著增加(P<0.01),血清IL-6、IL-1β和MMP-9含量显著升高(P<0.01),脑组织ZO-1,Claudin-5蛋白表达水平显著降低(P<0.01),P-gp,MRP1蛋白表达水平显著升高(P<0.01);与模型组比较,各给药组大鼠14 d神经功能评分明显降低(P<0.05,P<0.01),且有效改善脑组织病理变化,显著降低脑梗死率(P<0.01),血清IL-6、IL-1β、MMP-9表达水平明显降低(P<0.05,P<0.01),VEGFR2含量显著增加(P<0.01),中药高、中剂量组及脑心通组VEGF含量明星增加(P<0.05,P<0.01),中药低剂量组虽有下降趋势,但差异无统计学意义,中药高剂量组和脑心通组脑组织ZO-1、Claudin-5蛋白表达水平明显升高(P<0.05,P<0.01),P-gp、MRP1蛋白表达水平明显降低(P<0.05)。结论:黄芪赤风汤可以通过改善脑组织病理变化,减少炎症反应、促进血管生成、调节血脑屏障(BBB)功能,从而发挥治疗脑梗死作用。 展开更多
关键词 黄芪赤风汤 脑梗死 炎症 血管生成 血脑屏障 紧密连接蛋白
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Clinical efficacy evaluation of body acupuncture and scalp acupuncture combined with extracorporeal shock wave for scapulohumeral periarthritis 被引量:8
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作者 Miao ZHANG Cheng-xin FAN +2 位作者 Peng-yu ZHU Hai QIN Yan WANG 《World Journal of Acupuncture-Moxibustion》 CSCD 2019年第2期108-112,共5页
Objective:To observe the short-and long-term clinical efficacy differences of body acupuncture and scalp acupuncture combined with extracorporeal shock wave and simple extracorporeal shock wave.Methods:Sixty patients ... Objective:To observe the short-and long-term clinical efficacy differences of body acupuncture and scalp acupuncture combined with extracorporeal shock wave and simple extracorporeal shock wave.Methods:Sixty patients with scapulohumeral periarthritis were randomly divided into two groups:the treatment group and control group,30 cases in each one.Both groups underwent basic rehabilitation training.Patients in the treatment group were treated with body acupuncture and scalp acupuncture combined with extracorporeal shock wave.Yújì(鱼际 LU10),Hégǔ(合谷L14),Zhōngzhǔ(中渚TE3),Hòuxī(后溪SI3).There were three needles for the scalp acupuncture with the first between Shéntíng(神庭 GV24)and Yìntáng(印堂 EX-HN3),and the other two straightly through the inner canthus and parallel to the first needle.Shock wave treatment was intensively applied in some pressure points around shoulder joint.The control group used the same shock wave therapy as the treatment group.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.VAS score,the Constant-Murley score and the HAMA(the Hamilton Anxiety Scale)are as therapeutic effect index.30 days telephone investigation followed-up after the treatment course was evaluated.Results:Totally 28 cases completed the clinical observation in the treatment group,and 29 cases in the control group.The total effective rate of the treatment group was 85.7%(24/28),which was higher than 69.0%(20/29)of the control group(P<0.05).VAS score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:6.67 ± 1.43 vs 3.47 ± 1.35,the control group:7.57 ± 1.31 vs 5.36 ± 1.45,both P<0.05).There were significant statistical differences before the treatment and at the follow-up in the two groups(the treatment group:6.67 ± 1.43 vs2.68±0.81,the control group:7.57±1.31 vs 4.56±1.35,both P<0.05).The VAS scores of the treatment group after treatment and at the follow-up were respectively lower than those of the control group(both P<0.05).Shoulder joints activity score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:54.65±1.65 vs 65.54±2.19,the control group:54.32 ± 2.31 vs 61.01 ± 0.95,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:54.65 ± 1.65 vs 66.18± 1.35,the control group:54.32 ± 2.31 vs 62.11 ± 1.49,both P<0.05).The shoulder activity scores of the treatment group after treatment and at follow-up were respectively higher than those of the control group(both P<0.05).HAMA scores:There were singificant statistical differences before and after treatment in the two groups(the treatment group:16.83 ± 1.56 vs 13.26 ± 2.36,the control group:17.04 ± 1.84 vs 15.23 ±3.17,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:16.83 ± 1.56 vs 11.01 ± 3.20,the control group:17.04 ± 1.84 vs 13.68 ± 2.49,both P<0.05).The HAMA scores of the treatment group after treatment and at follow-up were lower than those of the control group(both P<0.05).Conclusion:Body acupuncture and scalp acupuncture combined with extracorporeal shock wave can relieve the clinical symptoms of patients with scapulohumeral periarthritis,ease anxiety and improve daily life activities. 展开更多
关键词 ACUPUNCTURE THERAPY Scapulohumeral PERIARTHRITIS EXTRACORPOREAL shock wave EMOTIONAL area
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Clinical effect on knee osteoarthritis treated with Fu’s subcutaneous needling therapy 被引量:7
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作者 Zheng LIU Lin MA Hai-yang BI 《World Journal of Acupuncture-Moxibustion》 CSCD 2020年第1期29-32,共4页
Objective:To observe and compare the clinical effect on knee osteoarthritis(KOA)between Fu’s subcutaneous needling therapy(FSN)and convention acupuncture.Methods:A total of 80 outpatients with KOA were divided into a... Objective:To observe and compare the clinical effect on knee osteoarthritis(KOA)between Fu’s subcutaneous needling therapy(FSN)and convention acupuncture.Methods:A total of 80 outpatients with KOA were divided into a FSN group(40 cases)and a conventional acupuncture group(40 cases)according to random number table.Within 1 week of treatment,FSN was used once every two days in the FSN group.The needle tip of Fu’s subcutaneous needle was inserted toward the affected muscle,about 5 mm in depth,at the angle of 15 to 25°.After the needle body lifted slightly,the needle went forward subcutaneously for 25 to 35 mm in depth and was swiped side to side horizontally with even exertion for about 1 min.According to the distribution of affected muscle,the reperfusion approach was repeated for 3 times consecutively.In the conventional acupuncture group conventional acupuncture was given,once a day,for 6 times totally.The scores of Western Ontario and McMaster universities osteoarthritis index(WOMAC)and Lysholm knee scoring scale(Lysholm)were compared between the two groups before and after 1-week treatment.The clinical effect of the two groups was analyzed statistically and evaluated.Results:After 1-week treatment with FSN,in the FSN group,the score of WOMACpain was reduced to be7.7±1.9 from 18.5±3.2,the score of WOMACstiffnessto be 1.5±0.7 from 4.5±1.8,WOMACfunction to be22.7±3.9 from 45.7±2.7 and the score of WOMACoverall to be 31.9±5.3 from 69.7±6.5.The differences were significant in comparison before and after treatment(all P<0.05).In the conventional acupuncture group,after 1-week treatment with conventional acupuncture,the score of WOMACpain was reduced to be11.3±2.8 from 18.2±3.0,the score of WOMACstiffness to be 3.0±1.6 from 5.6±1.7,WOMACfunction to be29.8±5.1 from 44.3±2.9 and the score of WOMACoverall to be 44.1±7.8 from 69.1±7.3.The differences were significant in comparison before and after treatment(all P<0.05).WOMAC score of every item in the FSN group was lower obviously than that in the conventional acupuncture group(P<0.01).After 1-week treatment,Lysholm score was increased to be 78.52±18.4 from 59.64±18.3 in the FSN group and it was to be 69.27±11.9 from 58.17±12.5 in the conventional acupuncture group.The differences were significant in comparison before and after treatment in either group(both P<0.05).Lysholm score in the FSN group was higher than that in the conventional acupuncture group(P<0.05).The total effective rate was 92.5%in the FSN group,higher than 77.5%in the conventional acupuncture group(P<0.05).Conclusion:Fu’s subcutaneous needling therapy effectively relieves the clinical symptoms of KOA and improves knee joint function.The therapeutic effect is better than that of the regular acupuncture. 展开更多
关键词 Fu’s SUBCUTANEOUS NEEDLING LOOSE CONNECTIVE tissue REPERFUSION approach Knee osteoarthritis
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Effect of electroacupuncture on knee osteoarthritis and relevant inflammatory factors:A randomized clinical trial 被引量:4
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作者 Yong LIU Hao WU 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第4期329-335,共7页
Objective:To explore the treatment effects of electroacupuncture(EA),acupuncture with filiform needle,and western medication for knee osteoarthritis(KOA).Methods:It was a randomized,controlled trial with the blinding ... Objective:To explore the treatment effects of electroacupuncture(EA),acupuncture with filiform needle,and western medication for knee osteoarthritis(KOA).Methods:It was a randomized,controlled trial with the blinding of outcome assessors and statistician.90 outpatients were diagnosed as KOA in Department of Acupuncture and Moxibustion,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.Using the random number table,they were divided into a medication group,an acupuncture group and an EA group,30 cases in each one.In the medication group,routine medication was provided with oral administration of celebrex for 21 days.Regular acupuncture was applied in the remaining groups,at Liángqiū(梁丘ST34),Xuèhǎi(血海SP10),Dúbí(犊鼻ST35),Nèixīyǎn(内膝眼EX-LE4),Yánglíngquán(阳陵泉GB34),Hèdǐng(鹤顶EX-LE2)and Sānyīnjiāo(三阴交SP6)and the needles were retained for 30 min.In the EA group,electric stimulation with low-frequency pulse current and dense wave was applied for 30 min on the basis of the treatment of the acupuncture group.The treatment was applied once daily at 1-day intervals after each 6-day treatment for a total of 21 days.Western Ontario and McMaster University Osteoarthritis Index(WOMAC)and visual analogy scale(VAS)scores and levels of serum inflammatory factors(interleukin-1β[IL-1β]and tumor necrosis factor[TNF-α])were used to assess the clinical therapeutic effect.Results:Following treatment,there were significant differences in the WOMAC score in the medication,acupuncture,and EA groups after treatment(all P<0.01).In the comparison among groups,after treatment,the WOMAC score in the EA group was lower than that in either the acupuncture or medication group(both P<0.01).Compared to before treatment,VAS scores were significantly different in the medication group(3.95±0.55 vs 5.75±1.40),the acupuncture group(2.78±0.38 vs 5.78±1.44)and EA group(1.72±0.38 vs 5.78±1.39)separately after treatment(all P<0.01).In the comparison among groups,after treatment,the VAS score in the EA group was lower than that in either the acupuncture or medication group(both P<0.01).Compared to before treatment,IL-1βlevels were significantly different in the medication group(31.53±6.84 vs 63.33±10.25),acupuncture group(31.70±7.54 vs63.90±9.96)and the EA groups(23.43±3.94 vs 63.10±10.66)separately after treatment(all P<0.01).IL-1βlevels were significantly lower in the EA group than in the acupuncture and medication groups(both P<0.01).Compared to before treatment,TNF-αlevels were significantly different in the medication group(40.20±6.09 vs 68.77±11.13),the acupuncture group(39.60±7.55 vs 68.33±11.51)and the EA groups(22.17±5.72 vs 68.97±10.52)separately after treatment(all P<0.01).TNF-αlevels were significantly lower in the EA group than in the acupuncture and medication groups(both P<0.01).After treatment,there were no significant differences in TNF-αand IL-1βlevels between the acupuncture and medication groups(both P>0.05).The total effective rates were 86.67%(26/30),73.33%(22/30)and70.00%(21/30)in the EA,acupuncture,and medication groups,respectively.The total effective rate was higher in the EA group than in either the acupuncture or medication group(both P<0.05).In the whole process of trial,the adverse events occurred in three groups.In consideration of the potential association between these adverse events and acupuncture treatment,the acupuncture physiotherapists and experts classified the adverse events into the treatment relevance or non-treatment relevance within 24 h of occurrence.Conclusion:All three therapeutic methods alleviated clinical symptoms of KOA and reduced levels of relevant inflammatory factors in serum.EA with dense wave is more advantageous than the traditional acupuncture technique and routine medication and is therefore worthy of clinical application. 展开更多
关键词 Knee osteoarthritis PAIN ACUPUNCTURE ELECTROACUPUNCTURE Dense wave
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Regular acupuncture at combined with join valley needling at ashi point for scapulohumeral periarthritis: A randomized controlled trial 被引量:7
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作者 Miao ZHANG Cheng-xin FAN +2 位作者 Peng-yu ZHU Wen-ting NIE Hai QIN 《World Journal of Acupuncture-Moxibustion》 CSCD 2019年第4期269-273,共5页
Objective:To observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohume... Objective:To observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohumeral periarthritis.Methods:Sixty-four patients of scapulohumeral periarthritis were randomly divided into an observation group and a control group,32 cases in each one.Both groups underwent basic rehabilitation training.Patients in the observation group were treated with acupuncture at empirical acupoints combined with join valley needling at ashi point,while the patients of the control group were treated with simple join valley needling at ashi point.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.The visual analog scale(VAS)score,the Constant-Murley score and the Hamilton Anxiety Scale(HAMA)are compared between the two groups before and after the treatment,and the efficacy was evaluated after the treatment.Telephone investigation was applied as the followed-up after one month of the treatment.Results:The total effective rate in the observation group was 87.5%(28/32),and that in the control group was 71.9%(23/32),and there was statistically significant difference between the two groups(P<0.05).The VAS scores,Constant-Murley scores,and HAMA scores in the patients of the observation group were lower than those of the corresponding indicators in the patients of the control group respectively,and there were statistically significant differences(all P<0.05).Conclusions:Compared with simple join valley needling at ashi point,regular acupuncture at empirical acupoints combined with join valley needling at ashi point can relieve the clinical symptoms of patients with scapulohumeral periarthritis,attenuate pains,ease anxiety and improve daily life activities better. 展开更多
关键词 Ashi point Join valley needling Scapulohumeral periarthritis
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Combined acupuncture and Chinese herb decoction for 5 cases with graphospasm 被引量:2
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作者 Miao ZHANG Ying ZHAO +2 位作者 Kun-peng XIA Cheng-xin FAN Yang LIU( 《World Journal of Acupuncture-Moxibustion》 CSCD 2020年第1期74-77,共4页
Combined acupuncture and Chinese herb decoction were applied for 5 cases with graphospasm.Acupuncture included scalp acupuncture and body acupuncture.Using transcranial repeated needling,Baihui(百会GV20),Chorea-trembl... Combined acupuncture and Chinese herb decoction were applied for 5 cases with graphospasm.Acupuncture included scalp acupuncture and body acupuncture.Using transcranial repeated needling,Baihui(百会GV20),Chorea-trembling controlled area,Emotional area,as well as Dazhui(大椎GV14),Fengchi(风池GB20),and Yingxiang(迎香EX-HN8)etc.were stimulated by proposed by Sun Shentian.Meanwhile,the patients took orally Chinese herb decoction,on the basis of the Siwu decoction(四物汤four substances decoction)addition and subtraction,relieve symptoms under syndrome differentiation.The treatment was carried out for 4 courses in total.One course consisted of 5 days,with an interval of 2 days between two courses.After treatment of 5 patients,2 patients were cured,2 patients achieved markedly effective response,and 1 patient achieved effective response. 展开更多
关键词 Graphospasm COMBINED ACUPUNCTURE and Chinese HERB DECOCTION TRANSCRANIAL repeated NEEDLING Liver and kidney yin deficiency Blood failing to nourish the sinews Electroacupuncture
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Effects of 30 cases of nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture 被引量:1
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作者 Xiao-xiao YU Guo-chen SHI 《World Journal of Acupuncture-Moxibustion》 CSCD 2019年第2期153-155,共3页
Objective:To observe the clinical therapeutic effects on nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture.Methods:Acupuncture was applied in 30 eligible patients with ner... Objective:To observe the clinical therapeutic effects on nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture.Methods:Acupuncture was applied in 30 eligible patients with nervous olfactory disorder.The points included three nasal points,i.e.,Yíngxiāng(迎香 LI 20),Shàngyíngxiāng(上迎香 EX-HN 8)and Yìntáng(印堂EX-HN 3),ézhōngxiàn(额中线 middle line of forehead,MS1)and bilateral Nièhòuxiàn(颖后线 posterior temporal line,MS11).The even-needling technique was used to stimulate the three nasal points to ensure deqi. In scalp acupuncture,the needle was rotated continuously at 200 times per min,for 2 min at each scalp acupuncture line.The needles were retained for 40 min at above points and lines and were manipulated once every 20 min during needle retaining.The treatment was given once a day,6-day treatment was as one course and the next course of treatment started after the interval of 1 day.Totally,4 courses of treatment were required.Before and after treatment,T&T olfactory was adopted to test the olfactory function and the score was compared in order to evaluate the therapeutic effect.Results:Of 30 cases,8 cases were cured,20 cases remarkably effective and 2 cases failed.The total effective rate was 93%.Conclusion:Acupuncture at three nasal points and scalp acupuncture are effective approach to nervous olfactory disorder. 展开更多
关键词 ACUPUNCTURE therapy THREE NASAL POINTS Scalp ACUPUNCTURE OLFACTORY DISORDER
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Acupuncture for 14 cases of Meige’s syndrome Ⅱ 被引量:2
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作者 Mi-mi Li Jin-cheng Ma +1 位作者 Kai Zong Dong-yan Wang 《World Journal of Acupuncture-Moxibustion》 CSCD 2019年第4期308-311,共4页
Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),S... Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Tāixī(太溪KI3),dance tremor control area of scalp acupuncture(舞蹈震颤控制区),Yángbái(阳白GB14),Sīzhúkōng(丝竹空TE23),Yíngxiāng(迎香LI20),Dìcāng(地仓ST4),Jiāchē(颊车ST6) and Xiàguān(下关ST7),and the needle retention continued for 40 min.The treatment was applied once a day,and there was a 5-day treatment and a 2-day rest every week.One course of treatment included a week,and there were 4 courses of treatment in total.After treatment,the clinical efficacy of the patients was evaluated.Results:4 cases were cured,9 cases were effective,1 case was ineffective,and the effective rate was 92.9%.Conclusions:Acupuncture had a satisfactory clinical therapeutic effect on patients of Meige’s syndrome Ⅱ. 展开更多
关键词 Acupuncture therapy Dance tremor control area Meige syndromeⅡ
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