Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia.T...Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia.Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology,skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.展开更多
Pituitary growth hormone (GH) evolves very slowly in most of mammals, but the evolutionary rates ap- pear to have increased markedly on two occasions during the evolution of primates and ruminants. To investigate the ...Pituitary growth hormone (GH) evolves very slowly in most of mammals, but the evolutionary rates ap- pear to have increased markedly on two occasions during the evolution of primates and ruminants. To investigate the evo- lutionary pattern of growth hormone receptor (GHR), we sequenced the extracellular domain of GHR genes from four primate species. Our results suggested that GHR in mammal also shows an episodic evolutionary pattern, which is consis- tent with that observed in pituitary growth hormone. Fur- ther analysis suggested that this pattern of rapid evolution observed in primates and ruminants is likely the result of coevolution between pituitary growth hormone and its re- ceptor.展开更多
文摘Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia.Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology,skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.
基金This work was supported by Yunnan Science and Technology Commitee,and the National Natural Science Foundation of China(Grant Nos.30021004&3043010).
文摘Pituitary growth hormone (GH) evolves very slowly in most of mammals, but the evolutionary rates ap- pear to have increased markedly on two occasions during the evolution of primates and ruminants. To investigate the evo- lutionary pattern of growth hormone receptor (GHR), we sequenced the extracellular domain of GHR genes from four primate species. Our results suggested that GHR in mammal also shows an episodic evolutionary pattern, which is consis- tent with that observed in pituitary growth hormone. Fur- ther analysis suggested that this pattern of rapid evolution observed in primates and ruminants is likely the result of coevolution between pituitary growth hormone and its re- ceptor.
