Lithium-sulfur(Li-S)batteries are promising next-generation high energy density batteries but their practical application is hindered by several key problems,such as the intermediate polysulfide shuttling and the elec...Lithium-sulfur(Li-S)batteries are promising next-generation high energy density batteries but their practical application is hindered by several key problems,such as the intermediate polysulfide shuttling and the electrode degradation caused by the sulfur volume changes.Binder acts as one of the most essential components to build the electrodes of Li-S batteries,playing vital roles in improving the performance and maintaining the integrity of the cathode structure during cycling,especially those with high sulfur loadings.To date,tremendous efforts have been devoted to improving the properties of binders,in terms of the viscosity,elasticity,stability,toughness and conductivity,by optimizing the composition and structure of polymer binders.Moreover,the binder modification endows them strong polysulfide trapping ability to suppress the shuttling and decreases the swelling to maintain the porous structure of cathode.In this review,we summarize the recent progress on the binders for Li-S batteries and discuss the various routes,including the binder combination use,functionalization,in-situ polymerization and ion cross-linking,etc.,to enhance their performance in stabilizing the cathode,building the high sulfur loading electrode and improving the cyclic stability.At last,the design principles and the problems in further applications are also highlighted.展开更多
Carbon-based materials have attracted much interest as one of the promising anodes for sodium-ion batteries. However, low utilization of electrolyte and slow ion-transfer rate during electrochemical process hinder the...Carbon-based materials have attracted much interest as one of the promising anodes for sodium-ion batteries. However, low utilization of electrolyte and slow ion-transfer rate during electrochemical process hinder the further application of traditional bulk carbon. In order to enhance the diffusion kinetics and maintain the reversibility, hierarchical hollow carbon microbox was successfully prepared through a tunable bottom-up self-template routine for sodium-ion batteries. During annealing process, the morphology construction and activation happened synchronously. Based on that, a range of cross-linked porous nanosheet and hollow microbox were attained by manipulating reactant condition. The generation of texture and physical property are analyzed and are established linkages related to the electrochemical behavior. As results depicted in kinetic exploration and simulation based on cyclic voltammetry, the surfacecontrolled electrochemical behavior gradually turns to be the diffusion-controlled behavior as the hollow microbox evolves to porous nanosheet. The probable reason is that the rational microstructure/texture design leads to the accelerated diffusion kinetic procedure and the reduced concentration difference polarization. Sodium storage mechanism was deduced as reversible binding of Na-ions with local defects,including vacancies on sp2 graphitic layers, at the edges of flakes and other structural defects instead of intercalation. Bestowed by the morphology design, the broad pore width distribution, abundant defects/active sites and surface functionality, hollow microbox electrode delivers great electrochemical performances. This work is expected to propose a novel and effective strategy to prepare tunable hierarchical hollow carbon microbox and induce the fast kinetic of carbon anode material.展开更多
Ophiolites represent fragments of ancient oceanic lithosphere,tectonically incorporated into continental margins during plate subduction or remained in the subduction–collisional orogenic belt.They provide
The influence of undercooling and noise magnitude on dendritic sidebranching during crystal growth was investigated by simulation of a phase-field model which incorporates thermal noise. It is shown that, the sidebran...The influence of undercooling and noise magnitude on dendritic sidebranching during crystal growth was investigated by simulation of a phase-field model which incorporates thermal noise. It is shown that, the sidebranching is not influenced with inclusion of the nonconserved noise, therefore, in order to save the computational costs it is often neglected; while conserved noise drives the morphological instability and is dominant origin of sidebranching. The dependence of temperature field on magnitude of thermal noise is apparent, when F_u gets an appropriate value, noise can induce sidebranching but not influence the dendritic tip operating state. In the small undercooled melt, the thermal diffusion layer collected around the dendrite is thick, which suppresses the growth of its sidebranching and makes the dendrite take on the morphology of no sidebranching, but when the undercooling is great, the thermal diffusion layer is thin, which is advantageous to the growth of the sidebranching and the dendrite presents the morphology of the developed sidebranching.展开更多
In the spacer acquisition stage of CRISPR-Cas immunity,spacer orientation and protospacer adjacent motif(PAM)removal are two prerequisites for functional spacer integration.Cas4 has been implicated in both processing ...In the spacer acquisition stage of CRISPR-Cas immunity,spacer orientation and protospacer adjacent motif(PAM)removal are two prerequisites for functional spacer integration.Cas4 has been implicated in both processing the prespacer and determining the spacer orientation.In Cas4-lacking systems,host 3′–5′DnaQ family exonucleases were recently reported to play a Cas4-like role.However,the molecular details of DnaQ functions remain elusive.Here,we characterized the spacer acquisition of the adaptation module of the Streptococcus thermophilus type I-E system,in which a DnaQ domain naturally fuses with Cas2.We presented X-ray crystal structures and cryo-electron microscopy structures of this adaptation module.Our biochemical data showed that DnaQ trimmed PAM-containing and PAM-deficient overhangs with different efficiencies.Based on these results,we proposed a time-dependent model for DnaQ-mediated spacer acquisition to elucidate PAM removal and spacer orientation determination in Cas4-lacking CRISPR-Cas systems.展开更多
In this study, a nonlinear model is presented for analysis of damage-cracking behavior in arch dams during strong earthquakes using different seismic input mechanisms. The nonlinear system includes a plastic-damage mo...In this study, a nonlinear model is presented for analysis of damage-cracking behavior in arch dams during strong earthquakes using different seismic input mechanisms. The nonlinear system includes a plastic-damage model for cyclic loading of concrete considering strain softening and a contact boundary model of contraction joint opening. Two different earthquake input mechanisms are used for comparison, including massless foundation input model and viscous-spring boundary model considering radiation damping due to infinite canyon. The results demonstrate that effects of seismic input mechanism and radiation damping on nonlinear response and damage-cracking of the dam are significant. Compared with the results of using massless foundation input model, the damage-cracking region and contraction joint opening are substantially reduced when using viscous-spring boundary model to take into account radiation damping. However, if the damping ratio of the dam is artificially increased to about 10%―15% for massless foundation input model, the joint opening and damage-cracking of the dam are comparable to the results obtained from the viscous-spring boundary model.展开更多
Atomically dispersing metal atoms on supports has been emerging as an effective strategy to maximize the atom utilization of metals for catalysis. However, due to the lack of effective tools to characterize the detail...Atomically dispersing metal atoms on supports has been emerging as an effective strategy to maximize the atom utilization of metals for catalysis. However, due to the lack of effective tools to characterize the detailed structure of metal-support interface, the chemical functions of supports in atomically dispersed metal catalysts are hardly elucidated at the molecular level. In this work, an atomically dispersed Pd_1/TiO_2 catalyst with Ti(Ⅲ) vicinal to Pd is prepared and used to demonstrate the direct involvement of metal atoms on support in the catalysis of dispersed metal atoms. Systematic studies reveal that the Ti(Ⅲ)-O-Pd interface facilitates the activation of O_2 into superoxide(O_2^-), thus promoting the catalytic oxidation. The catalyst exhibits the highest CO turn-over frequency among ever-reported Pd-based catalysts,and enhanced catalysis in the combustion of harmful volatile organic compound(i.e., toluene) and greenhouse gas(i.e., methane). The demonstrated direct involvement of metal atoms on oxide support suggests that the real active sites of atomically dispersed metal catalysts can be far beyond isolated metal atoms themselves. Metal atoms on oxide supports in the vicinity serve as another vector to promote the catalysis of atomically dispersed metal catalysts.展开更多
In quantum interferometry, it is vital to control and utilize nonlinear interactions for the achievement of high-precision measurements. Due to their long coherence time and high controllability, ultracold atoms inclu...In quantum interferometry, it is vital to control and utilize nonlinear interactions for the achievement of high-precision measurements. Due to their long coherence time and high controllability, ultracold atoms including Bose condensed atoms have been widely used for quantum interferometry. Here, we review recent progress in theoretical studies of quantum interferometry with Bose condensed atoms. In particular, we focus on nonlinear phenomena induced by atom-atom interactions, and how to control and utilize these nonlinear phenomena. With a mean-field description, due to atom-atom interactions, matter-wave solitons appear in the interference patterns, and macroscopic quantum self-trapping exists in Bose-Josephson junctions. With a many-body description, atom-atom in- teractions can generate non-classical entanglement, which can be utilized to achieve high-precision measurements beyond the standard quantum limit.展开更多
Organic solar cells(OSCs)have made fast advance with prominent power conversion efficiencies(PCEs)achieved in non-fullerene OSCs in recent years[1].Among various types of OSCs,allpolymer solar cells(APSCs)consisting o...Organic solar cells(OSCs)have made fast advance with prominent power conversion efficiencies(PCEs)achieved in non-fullerene OSCs in recent years[1].Among various types of OSCs,allpolymer solar cells(APSCs)consisting of a polymer donor and a polymer acceptor are promising power sources for portable and wearable electronics due to their intrinsic advantages in device stability and mechanical flexibility[2].展开更多
Separated Function RFQ (SFRFQ) was proposed as a post accelerator of RFQ to accelerate heavy ions at low frequency. It introduces gap accelerating in the quadrupole electrodes, and therefore it has higher accelerating...Separated Function RFQ (SFRFQ) was proposed as a post accelerator of RFQ to accelerate heavy ions at low frequency. It introduces gap accelerating in the quadrupole electrodes, and therefore it has higher accelerating efficiency than the conventional RFQ accelerator. The first SFRFQ prototype cavity has been specially designed and constructed as a post accelerator to accelerate O+ beam from 1.03 MeV to 1.64 MeV. Based on accomplishment of low power measurement and high power test, the beam commissioning was carried out to verify its feasibility. The measured energy gain per cell of SFRFQ is 45 keV, which is about 60% higher than that of Peking University Integral Split Ring (ISR) RFQ.展开更多
Objective: To investigate whether electroacupuncture (EA) can promote cell survival and enhance heart function of mesenchymal stem cells (MSCs) therapy. Methods: MSCs were isolated from bone marrow and expanded ...Objective: To investigate whether electroacupuncture (EA) can promote cell survival and enhance heart function of mesenchymal stem cells (MSCs) therapy. Methods: MSCs were isolated from bone marrow and expanded in Minimum Essential Medium Alpha (α-MEM). MI was induced in 72 Sprague-Dawley (S-D) rats by ligation of the left anterior descending coronary artery (LAD) for 30 min and reperfusion. MI rats randomly received injection of 1 x 106 Dil-labeled MSCs alone (n=24, MSC group), or plus electroacupuncture (EA) at Neiguan (PC6, n=24, EA+MSC group), or saline (n=24, saline group). EA treatment was performed for 4 days. Another 24 rats were subjected to chest-open surgery without LAD occlusion and treatment (sham group). Three time points, 4, 14 and 28 days (n=8 for each group) were included in this study. The survival of transplanted MSCs and the protective gene expression were analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot at day 4 and 14. Left ventricular remodeling, cardiac function, infarction area, fibrosis and capillary density were analyzed at day 28. Results: EA can enhance MSC survival (2.6-fold up) at day 4. Big capillary density was 53% higher in EA+MSC treated group than MSC alone group. Furthermore, the rats treated by EA reduced the fibrosis and had 36% smaller infarct size comparing to MSC alone. EA also attenuated left ventricular remodeling and enhanced the functional recovery of infarcted hearts at week 4. Conclmion: EA at Neiguan acupoint can promote the stem cell survival and improve ischemic heart function. EA could become a useful approach in stem cell therapy for ischemia heart diseases.展开更多
The evolution of particle size distribution (PSD) of fine polydisperse particles at high number concen- trations (7105 cm-3) was simulated through a combined model employing direct quadrature method of moments (D...The evolution of particle size distribution (PSD) of fine polydisperse particles at high number concen- trations (7105 cm-3) was simulated through a combined model employing direct quadrature method of moments (DQMOM) with heat and mass transfer equations. The PSD was assumed to retain log-normal distribution during the heterogeneous condensation process. The model was first verified by exact solu- tion and experimental data prior to investigating the influence of initial conditions on final PSD under an octadecane-nitrogen atmosphere. Low particle number concentrations and high vapor concentrations were beneficial to shift the PSD to larger particles having a narrower distribution. Additionally, vapor depletion has more influence on the final PSD than the heat release parameter for a number concentra- tion of 10^6 cm^-3. This study may assist the design process of a gas-solid separating cyclone, to eliminate dust from high-temperature volatiles by pyrolysis of solid fuels.展开更多
The circadian clock,a time-keeping mechanism,drives nearly 24-h self-sustaining rhythms at the physiological,cellular,and molecular levels,keeping them synchronized with the cyclic changes of environmental signals.The...The circadian clock,a time-keeping mechanism,drives nearly 24-h self-sustaining rhythms at the physiological,cellular,and molecular levels,keeping them synchronized with the cyclic changes of environmental signals.The plant clock is sensitive to external and internal stress signals that act as timing cues to influence the circadian rhythms through input pathways of the circadian clock system.In order to cope with environmental stresses,many core oscillators are involved in defense while maintaining daily growth in various ways.Recent studies have shown that a hierarchical multi-oscillator network orchestrates the defense through rhythmic accumulation of gene transcripts,alternative splicing of mRNA precursors,modification and turnover of proteins,subcellular localization,stimuli-induced phase separation,and long-distance transport of proteins.This review summarizes the essential role of circadian core oscillators in response to stresses in Arabidopsis thaliana and crops,including daily and seasonal abiotic stresses(low or high temperature,drought,high salinity,and nutrition deficiency)and biotic stresses(pathogens and herbivorous insects).By integrating time-keeping mechanisms,circadian rhythms and stress resistance,we provide a temporal perspective for scientists to better understand plant environmental adaptation and breed high-quality crop germplasm for agricultural production.展开更多
Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs(genus phyllomedusa) in 1989, which have a higher affinity and selectivity for δopioidbinding sites than any other known natural co...Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs(genus phyllomedusa) in 1989, which have a higher affinity and selectivity for δopioidbinding sites than any other known natural compound. The analgesic activity,展开更多
It is highly desired to have bioactive surfaces for biomaterials and controllable interactions with cells.These functions were widely achieved by attaching functional peptides to the surface of biomaterials.It is well...It is highly desired to have bioactive surfaces for biomaterials and controllable interactions with cells.These functions were widely achieved by attaching functional peptides to the surface of biomaterials.It is well known that an antifouling layer can help reducing the nonspecific cell attachment.However,it is unclear how an antifouling PEG layer affects the function of peptides attached on material surface in controlling cell behavior.This highlight introduced the recent JACS paper from Prof.Liu and coworkers in addressing this question thoroughly.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51772164 and U1601206)the Guangdong Natural Science Funds for Distinguished Young Scholars(2017B030306006)+2 种基金the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01N111)the Guangdong Special Support Program(2017TQ04C664)the Shenzhen Basic Research Project(Grant Nos.JCYJ20170412171359175)
文摘Lithium-sulfur(Li-S)batteries are promising next-generation high energy density batteries but their practical application is hindered by several key problems,such as the intermediate polysulfide shuttling and the electrode degradation caused by the sulfur volume changes.Binder acts as one of the most essential components to build the electrodes of Li-S batteries,playing vital roles in improving the performance and maintaining the integrity of the cathode structure during cycling,especially those with high sulfur loadings.To date,tremendous efforts have been devoted to improving the properties of binders,in terms of the viscosity,elasticity,stability,toughness and conductivity,by optimizing the composition and structure of polymer binders.Moreover,the binder modification endows them strong polysulfide trapping ability to suppress the shuttling and decreases the swelling to maintain the porous structure of cathode.In this review,we summarize the recent progress on the binders for Li-S batteries and discuss the various routes,including the binder combination use,functionalization,in-situ polymerization and ion cross-linking,etc.,to enhance their performance in stabilizing the cathode,building the high sulfur loading electrode and improving the cyclic stability.At last,the design principles and the problems in further applications are also highlighted.
基金supported by National Postdoctoral Program for Innovative Talents (BX201600192)the National Natural Science Foundation of China (51904342,21673298)+2 种基金China Postdoctoral Science Foundation (2017M6203552)National Key Research and Development Program of China (2017YFB0102000,2018YFB0104200)Hunan Provincial Science and Technology Plan (2017TP1001)。
文摘Carbon-based materials have attracted much interest as one of the promising anodes for sodium-ion batteries. However, low utilization of electrolyte and slow ion-transfer rate during electrochemical process hinder the further application of traditional bulk carbon. In order to enhance the diffusion kinetics and maintain the reversibility, hierarchical hollow carbon microbox was successfully prepared through a tunable bottom-up self-template routine for sodium-ion batteries. During annealing process, the morphology construction and activation happened synchronously. Based on that, a range of cross-linked porous nanosheet and hollow microbox were attained by manipulating reactant condition. The generation of texture and physical property are analyzed and are established linkages related to the electrochemical behavior. As results depicted in kinetic exploration and simulation based on cyclic voltammetry, the surfacecontrolled electrochemical behavior gradually turns to be the diffusion-controlled behavior as the hollow microbox evolves to porous nanosheet. The probable reason is that the rational microstructure/texture design leads to the accelerated diffusion kinetic procedure and the reduced concentration difference polarization. Sodium storage mechanism was deduced as reversible binding of Na-ions with local defects,including vacancies on sp2 graphitic layers, at the edges of flakes and other structural defects instead of intercalation. Bestowed by the morphology design, the broad pore width distribution, abundant defects/active sites and surface functionality, hollow microbox electrode delivers great electrochemical performances. This work is expected to propose a novel and effective strategy to prepare tunable hierarchical hollow carbon microbox and induce the fast kinetic of carbon anode material.
基金supported by the fundings (No. 41272242) from National Natural Science Foundation of China
文摘Ophiolites represent fragments of ancient oceanic lithosphere,tectonically incorporated into continental margins during plate subduction or remained in the subduction–collisional orogenic belt.They provide
文摘The influence of undercooling and noise magnitude on dendritic sidebranching during crystal growth was investigated by simulation of a phase-field model which incorporates thermal noise. It is shown that, the sidebranching is not influenced with inclusion of the nonconserved noise, therefore, in order to save the computational costs it is often neglected; while conserved noise drives the morphological instability and is dominant origin of sidebranching. The dependence of temperature field on magnitude of thermal noise is apparent, when F_u gets an appropriate value, noise can induce sidebranching but not influence the dendritic tip operating state. In the small undercooled melt, the thermal diffusion layer collected around the dendrite is thick, which suppresses the growth of its sidebranching and makes the dendrite take on the morphology of no sidebranching, but when the undercooling is great, the thermal diffusion layer is thin, which is advantageous to the growth of the sidebranching and the dendrite presents the morphology of the developed sidebranching.
基金National Natural Science Foundation of China(32270761,31741027,81672722,32222040 and 32070049)Ministry of Science and Technology(MoST)of China(2022YFC2303700 and 2021YFA301900)China Postdoctoral Science Foundation(2022M712272).
文摘In the spacer acquisition stage of CRISPR-Cas immunity,spacer orientation and protospacer adjacent motif(PAM)removal are two prerequisites for functional spacer integration.Cas4 has been implicated in both processing the prespacer and determining the spacer orientation.In Cas4-lacking systems,host 3′–5′DnaQ family exonucleases were recently reported to play a Cas4-like role.However,the molecular details of DnaQ functions remain elusive.Here,we characterized the spacer acquisition of the adaptation module of the Streptococcus thermophilus type I-E system,in which a DnaQ domain naturally fuses with Cas2.We presented X-ray crystal structures and cryo-electron microscopy structures of this adaptation module.Our biochemical data showed that DnaQ trimmed PAM-containing and PAM-deficient overhangs with different efficiencies.Based on these results,we proposed a time-dependent model for DnaQ-mediated spacer acquisition to elucidate PAM removal and spacer orientation determination in Cas4-lacking CRISPR-Cas systems.
基金Supported by the National Natural Science Foundation of China (Grant Nos.90510018,90715041)the National Basic Research Program of China ("973") (Grant No.2002CB412709)
文摘In this study, a nonlinear model is presented for analysis of damage-cracking behavior in arch dams during strong earthquakes using different seismic input mechanisms. The nonlinear system includes a plastic-damage model for cyclic loading of concrete considering strain softening and a contact boundary model of contraction joint opening. Two different earthquake input mechanisms are used for comparison, including massless foundation input model and viscous-spring boundary model considering radiation damping due to infinite canyon. The results demonstrate that effects of seismic input mechanism and radiation damping on nonlinear response and damage-cracking of the dam are significant. Compared with the results of using massless foundation input model, the damage-cracking region and contraction joint opening are substantially reduced when using viscous-spring boundary model to take into account radiation damping. However, if the damping ratio of the dam is artificially increased to about 10%―15% for massless foundation input model, the joint opening and damage-cracking of the dam are comparable to the results obtained from the viscous-spring boundary model.
基金supported by the National Key Research and Development Program of China(2017YFA0207302)the National Natural Science Foundation of China(21731005,21420102001,21373167,and 21573178)+1 种基金the National Postdoctoral Program for Innovative Talents(BX201600093)the China Postdoctoral Science Foundation Project(2017M610392)
文摘Atomically dispersing metal atoms on supports has been emerging as an effective strategy to maximize the atom utilization of metals for catalysis. However, due to the lack of effective tools to characterize the detailed structure of metal-support interface, the chemical functions of supports in atomically dispersed metal catalysts are hardly elucidated at the molecular level. In this work, an atomically dispersed Pd_1/TiO_2 catalyst with Ti(Ⅲ) vicinal to Pd is prepared and used to demonstrate the direct involvement of metal atoms on support in the catalysis of dispersed metal atoms. Systematic studies reveal that the Ti(Ⅲ)-O-Pd interface facilitates the activation of O_2 into superoxide(O_2^-), thus promoting the catalytic oxidation. The catalyst exhibits the highest CO turn-over frequency among ever-reported Pd-based catalysts,and enhanced catalysis in the combustion of harmful volatile organic compound(i.e., toluene) and greenhouse gas(i.e., methane). The demonstrated direct involvement of metal atoms on oxide support suggests that the real active sites of atomically dispersed metal catalysts can be far beyond isolated metal atoms themselves. Metal atoms on oxide supports in the vicinity serve as another vector to promote the catalysis of atomically dispersed metal catalysts.
基金supported by Chinese Academy of Sciences(KFZD-SW-112-02-04 and ZDRW-ZS-2019-2)the National Natural Science Foundation of China(31870218,31825003,31730103)the Strategic Priority Research Program"Molecular Mechanism of Plant Growth and Development"of the Chinese Academy of Sciences(XDB27040207).
文摘In quantum interferometry, it is vital to control and utilize nonlinear interactions for the achievement of high-precision measurements. Due to their long coherence time and high controllability, ultracold atoms including Bose condensed atoms have been widely used for quantum interferometry. Here, we review recent progress in theoretical studies of quantum interferometry with Bose condensed atoms. In particular, we focus on nonlinear phenomena induced by atom-atom interactions, and how to control and utilize these nonlinear phenomena. With a mean-field description, due to atom-atom interactions, matter-wave solitons appear in the interference patterns, and macroscopic quantum self-trapping exists in Bose-Josephson junctions. With a many-body description, atom-atom in- teractions can generate non-classical entanglement, which can be utilized to achieve high-precision measurements beyond the standard quantum limit.
基金supported by the National Natural Science Foundation of China(Grant Nos.50425204,50272032&90401012)the Ministry of Sciences and Technology of China through 973-Project(Grants 2002CB61306&2001CB6104).
基金the National Key Research and Development Program of China (2017YFA0206600 and 2019YFA0705900)the National Natural Science Foundation of China (21875072, 51773045, 21772030, 51922032 and 21961160720)。
文摘Organic solar cells(OSCs)have made fast advance with prominent power conversion efficiencies(PCEs)achieved in non-fullerene OSCs in recent years[1].Among various types of OSCs,allpolymer solar cells(APSCs)consisting of a polymer donor and a polymer acceptor are promising power sources for portable and wearable electronics due to their intrinsic advantages in device stability and mechanical flexibility[2].
基金supported by the National Natural Science Foundation of China (Grand No. 10905003)China Postdoctoral Science Foundation
文摘Separated Function RFQ (SFRFQ) was proposed as a post accelerator of RFQ to accelerate heavy ions at low frequency. It introduces gap accelerating in the quadrupole electrodes, and therefore it has higher accelerating efficiency than the conventional RFQ accelerator. The first SFRFQ prototype cavity has been specially designed and constructed as a post accelerator to accelerate O+ beam from 1.03 MeV to 1.64 MeV. Based on accomplishment of low power measurement and high power test, the beam commissioning was carried out to verify its feasibility. The measured energy gain per cell of SFRFQ is 45 keV, which is about 60% higher than that of Peking University Integral Split Ring (ISR) RFQ.
基金The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2012 *Supported by the National Natural Science Foundation of China (No. 30500645, 30570471,30725030) and National Key Project for Basic Research of China (No. 2011 CB964903 and 2005CB523502)
文摘Objective: To investigate whether electroacupuncture (EA) can promote cell survival and enhance heart function of mesenchymal stem cells (MSCs) therapy. Methods: MSCs were isolated from bone marrow and expanded in Minimum Essential Medium Alpha (α-MEM). MI was induced in 72 Sprague-Dawley (S-D) rats by ligation of the left anterior descending coronary artery (LAD) for 30 min and reperfusion. MI rats randomly received injection of 1 x 106 Dil-labeled MSCs alone (n=24, MSC group), or plus electroacupuncture (EA) at Neiguan (PC6, n=24, EA+MSC group), or saline (n=24, saline group). EA treatment was performed for 4 days. Another 24 rats were subjected to chest-open surgery without LAD occlusion and treatment (sham group). Three time points, 4, 14 and 28 days (n=8 for each group) were included in this study. The survival of transplanted MSCs and the protective gene expression were analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot at day 4 and 14. Left ventricular remodeling, cardiac function, infarction area, fibrosis and capillary density were analyzed at day 28. Results: EA can enhance MSC survival (2.6-fold up) at day 4. Big capillary density was 53% higher in EA+MSC treated group than MSC alone group. Furthermore, the rats treated by EA reduced the fibrosis and had 36% smaller infarct size comparing to MSC alone. EA also attenuated left ventricular remodeling and enhanced the functional recovery of infarcted hearts at week 4. Conclmion: EA at Neiguan acupoint can promote the stem cell survival and improve ischemic heart function. EA could become a useful approach in stem cell therapy for ischemia heart diseases.
基金This work was supported by the National Basic Research Pro- gram of China (973 Program, 2014CB744300), by the National Natural Science Foundation of China (51476180), and by Meso- science Innovation Fund (COM2015A004). Discussion with Dr. Susanne Hering on his experiment and effects of initial size is acknowledged.
文摘The evolution of particle size distribution (PSD) of fine polydisperse particles at high number concen- trations (7105 cm-3) was simulated through a combined model employing direct quadrature method of moments (DQMOM) with heat and mass transfer equations. The PSD was assumed to retain log-normal distribution during the heterogeneous condensation process. The model was first verified by exact solu- tion and experimental data prior to investigating the influence of initial conditions on final PSD under an octadecane-nitrogen atmosphere. Low particle number concentrations and high vapor concentrations were beneficial to shift the PSD to larger particles having a narrower distribution. Additionally, vapor depletion has more influence on the final PSD than the heat release parameter for a number concentra- tion of 10^6 cm^-3. This study may assist the design process of a gas-solid separating cyclone, to eliminate dust from high-temperature volatiles by pyrolysis of solid fuels.
基金supported by National Natural Science Foundation of China to X.X.(32170275,U1904202,31570285)Q.X.(32170259,31670285)National key research and development program to X.X.(2021YFA1300402).
文摘The circadian clock,a time-keeping mechanism,drives nearly 24-h self-sustaining rhythms at the physiological,cellular,and molecular levels,keeping them synchronized with the cyclic changes of environmental signals.The plant clock is sensitive to external and internal stress signals that act as timing cues to influence the circadian rhythms through input pathways of the circadian clock system.In order to cope with environmental stresses,many core oscillators are involved in defense while maintaining daily growth in various ways.Recent studies have shown that a hierarchical multi-oscillator network orchestrates the defense through rhythmic accumulation of gene transcripts,alternative splicing of mRNA precursors,modification and turnover of proteins,subcellular localization,stimuli-induced phase separation,and long-distance transport of proteins.This review summarizes the essential role of circadian core oscillators in response to stresses in Arabidopsis thaliana and crops,including daily and seasonal abiotic stresses(low or high temperature,drought,high salinity,and nutrition deficiency)and biotic stresses(pathogens and herbivorous insects).By integrating time-keeping mechanisms,circadian rhythms and stress resistance,we provide a temporal perspective for scientists to better understand plant environmental adaptation and breed high-quality crop germplasm for agricultural production.
基金Project supported by the National Natural Science Foundation of China, the State Education Commission of China and the National Laboratory for Dynamic and Stable State of Molecule.
文摘Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs(genus phyllomedusa) in 1989, which have a higher affinity and selectivity for δopioidbinding sites than any other known natural compound. The analgesic activity,
文摘It is highly desired to have bioactive surfaces for biomaterials and controllable interactions with cells.These functions were widely achieved by attaching functional peptides to the surface of biomaterials.It is well known that an antifouling layer can help reducing the nonspecific cell attachment.However,it is unclear how an antifouling PEG layer affects the function of peptides attached on material surface in controlling cell behavior.This highlight introduced the recent JACS paper from Prof.Liu and coworkers in addressing this question thoroughly.