Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical practice.Results Out of 1433 patients,453(31.6%)were octog...Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical practice.Results Out of 1433 patients,453(31.6%)were octogenarians at baseline.Compared to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5±1.3vs.3.0±1.4;P<0.001)and HAS-BLED scores(2.0±1.0vs.1.4±1.0;P<0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4%of patients,but more frequently in the younger population(71.1%vs.89.1%;P=0.039).After a mean follow-up of 2.2±0.6 years,annual rates of stroke+systemic embolism+transient ische-mic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03%and 1.75%,respectively,in octogenarian patients.Except for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar com-pared to younger patients.In octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independ-ently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with and higher HAS-BLED score with major bleeding.MACE,Conclusions In clinical practice,around one third of patients taking rivaroxaban are octogenarians.These patients have many comorbidities and a high thromboembolic risk.Despite that,rates of adverse events remain low.Rivaroxaban is adequately pre-scribed in the majority of octogenarians.展开更多
Various properties of the characteristic functions of random variables in a non-commutative C*-probability space are studied in this paper. It turns out that the distributions of random variables are uniquely determin...Various properties of the characteristic functions of random variables in a non-commutative C*-probability space are studied in this paper. It turns out that the distributions of random variables are uniquely determined by their characteristic functions. By using the properties of characteristic functions, a central limit theorem for a sequence of independent identically distributed random variables in a C*-probability space is established as well.展开更多
In this paper, we discuss the problem concerning global and local structure of solutions of an operator equation posed by M. S. Berger. Let f : U (?)E→ F be a C1 map, where E and F are Banach spaces and U is open in ...In this paper, we discuss the problem concerning global and local structure of solutions of an operator equation posed by M. S. Berger. Let f : U (?)E→ F be a C1 map, where E and F are Banach spaces and U is open in E. We show that the solution set of the equation f(x)=y for a fixed generalized regular value y of f is represented as a union of disjoint connected C1 Banach submanifolds of U, each of which has a dimension and its tangent space is given. In particular, a characterization of the isolated solutions of the equation f(x) = y is obtained.展开更多
The phenomenon of stochastic resonance (SR) is found in a single-mode laser system driven by the colored pump noise with signal modulation and the quantum noise with cross-correlation between the real and imaginary pa...The phenomenon of stochastic resonance (SR) is found in a single-mode laser system driven by the colored pump noise with signal modulation and the quantum noise with cross-correlation between the real and imaginary parts. When the net gain a0 changes, it is found that, 1) the shape of the curve of the signal-to-noise ratio (SNR) versus the pump noise self-correlation time τ exhibits a changing process of multiform SR, from single-peak SR, to simultaneous existence of resonances and suppressions; 2) the curve of SNR. versus signal frequency Ω experiences a complicated changing process from the monotonous descending to the simultaneous appearances of a maximum and a minimum, and finally to monotonous descending; 3) the curve of SNR versus cross-correlation coefficient between the real and imaginary parts of the quantum noise λq appears an acute single-peak SR. Therefore, the net gain ao greatly influences the characteristic of SR of laser system.展开更多
文摘Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical practice.Results Out of 1433 patients,453(31.6%)were octogenarians at baseline.Compared to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5±1.3vs.3.0±1.4;P<0.001)and HAS-BLED scores(2.0±1.0vs.1.4±1.0;P<0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4%of patients,but more frequently in the younger population(71.1%vs.89.1%;P=0.039).After a mean follow-up of 2.2±0.6 years,annual rates of stroke+systemic embolism+transient ische-mic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03%and 1.75%,respectively,in octogenarian patients.Except for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar com-pared to younger patients.In octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independ-ently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with and higher HAS-BLED score with major bleeding.MACE,Conclusions In clinical practice,around one third of patients taking rivaroxaban are octogenarians.These patients have many comorbidities and a high thromboembolic risk.Despite that,rates of adverse events remain low.Rivaroxaban is adequately pre-scribed in the majority of octogenarians.
基金the Shanghai Science and Technology Commission, No. 01ZA14003.
文摘Various properties of the characteristic functions of random variables in a non-commutative C*-probability space are studied in this paper. It turns out that the distributions of random variables are uniquely determined by their characteristic functions. By using the properties of characteristic functions, a central limit theorem for a sequence of independent identically distributed random variables in a C*-probability space is established as well.
基金Foundation item: The NSF (10271053) of China and the Doctoral Programme Foundation of Ministry of Education of China.
文摘In this paper, we discuss the problem concerning global and local structure of solutions of an operator equation posed by M. S. Berger. Let f : U (?)E→ F be a C1 map, where E and F are Banach spaces and U is open in E. We show that the solution set of the equation f(x)=y for a fixed generalized regular value y of f is represented as a union of disjoint connected C1 Banach submanifolds of U, each of which has a dimension and its tangent space is given. In particular, a characterization of the isolated solutions of the equation f(x) = y is obtained.
基金This work was supported by the National Natural Science Foundation of China under Grant No. 10275025.
文摘The phenomenon of stochastic resonance (SR) is found in a single-mode laser system driven by the colored pump noise with signal modulation and the quantum noise with cross-correlation between the real and imaginary parts. When the net gain a0 changes, it is found that, 1) the shape of the curve of the signal-to-noise ratio (SNR) versus the pump noise self-correlation time τ exhibits a changing process of multiform SR, from single-peak SR, to simultaneous existence of resonances and suppressions; 2) the curve of SNR. versus signal frequency Ω experiences a complicated changing process from the monotonous descending to the simultaneous appearances of a maximum and a minimum, and finally to monotonous descending; 3) the curve of SNR versus cross-correlation coefficient between the real and imaginary parts of the quantum noise λq appears an acute single-peak SR. Therefore, the net gain ao greatly influences the characteristic of SR of laser system.
