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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library
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作者 Shi-Qi Wang Xun Zhao +10 位作者 Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第5期722-732,共11页
Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon... Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products. 展开更多
关键词 Polysorbate 20 Component DATABASE DISCRIMINATION Degradation
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传统制造业变革IDEA创新驱动
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作者 王灿 《现代工业经济和信息化》 2019年第2期12-13,共2页
首先阐述了传统制造业变革的背景和目的,然后对IDEA(全称Informatization and Datamation for Engineer Analysis)的功能进行探索与完善,保证企业岗位传承的良性循环。
关键词 IDEA设备 工程技术 故障诊断
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早教在线
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作者 丛倩祯 《母婴世界》 2007年第10期86-87,共2页
Q我的宝宝1岁5个月,他只爱玩"厨房".包括玩具和家中的厨房实物。他只要一睡醒或有机会就往厨房跑,对其他玩具兴趣不高也没长性。这种行为是怎么回事?如何让宝宝也喜欢上其他的游戏?
关键词 家长 幼儿园 注意力 兴趣 讲故事 数字 主动学习 厨房 玩具 分离焦虑
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