Physical design and multi-particle simulations of a compact IH-DTL with KONUS beam dynamics for proton therapy

A compact room-temperature inter-digital H-mode(IH)drift tube linac(DTL)with Kombinierte Null Grad Struktur beam dynamics is proposed in this paper.The proposed IH-DTL,which operates at 325 MHz,accelerates 18 mA proton particles from 3.0 to 7.0 MeV as part of a proton synchrotron-based therapy system.It is composed of two main sections,namely a bunching section(-30°)and accelerating section(0°).There is no transverse focusing element inside the cavity,which increases the acceleration gradient and reduces the cavity length and power consumption.In our physical designs,LORASR code is utilized for beam dynamics design and multi-particle simulations.The synchronous particle energy,injection phase,and acceleration voltage of each gap are optimized carefully to increase transmission efficiency while minimizing beam emittance growth and beam loss.The total length of the cavity is 0.82 m and the acceleration gradient reaches 4.88 MV/m,resulting in a transmission efficiency of 100%and beam emittance growth less than10%.The details of the specific work undertaken in this study are presented in this paper.

Collection efficiency of a monitor parallel plate ionization chamber for pencil beam scanning proton therapy

The collection efficiency of monitor parallel plate ionization chambers is the main uncertainty in the beam control of pencil beam scanning systems.Existing calculation methods for collection efficiency in photon or passive scattering proton systems have not considered the characteristics of non-uniform charge density in pencil beam scanning systems.In this study,Boag’s theory was applied to a proton pencil beam scanning system.The transverse distribution of charge density in the ionization chamber was considered to be a Gaussian function and an analytical solution was derived to calculate collection efficiency in the beam spot area.This calculation method is called the integral method and it was used to investigate the effects of beam parameters on collection efficiency.It was determined that collection efficiency is positively correlated with applied voltage,beam size,and beam energy,but negatively correlated with beam current intensity.Additionally,it was confirmed that collection efficiency is improved when the air filling the monitor parallel plate ionization chamber is replaced with nitrogen.

GPU-accelerated scanning path optimization in particle cancer therapy

When using the beam scanning method for particle beam therapy, the target volume is divided into many iso-energy slices and is irradiated slice by slice. Each slice may comprise thousands of discrete scanning beam positions. An optimized scanning path can decrease the transit dose and may bypass important organs. The minimization of the scanning path length can be considered as a variation of the traveling salesman problem; the simulated annealing algorithm is adopted to solve this problem. The initial scanning path is assumed as a simple zigzag path;subsequently, random searches for accepted new paths are performed through cost evaluation and criteria-based judging. To reduce the optimization time of a given slice,random searches are parallelized by employing thousands of threads. The simultaneous optimization of multiple slices is realized by using many thread blocks of generalpurpose computing on graphics processing units hardware.Running on a computer with an Intel i7-4790 CPU and NVIDIA K2200 GPU, our new method required only 1.3 s to obtain optimized scanning paths with a total of 40 slices in typically studied cases. The procedure and optimization results of this new method are presented in this work.

Shortening the delivery time of proton therapy by real-time compensation method with raster scanning

Among the various scanning techniques, spot and raster scanning are the most frequently adopted. Raster scanning turns off the beam only when each isoenergy slice irradiation is completed. This feature intrinsically solves the leakage dose and frequent beam-switching problems encountered during spot scanning. However, to shorten the delivery time of raster scanning, a sophisticated dose control strategy is required to guarantee dose distribution.In this study, a real-time compensation method with raster scanning for synchrotron systems was designed. It is characterized by a small spot-spacing planning strategy and real-time subtraction of the transient number of particles delivered between two planning-spot positions from the planned number of particles of the subsequent raster point.The efficacy of the compensation method was demonstrated by performing accurate raster scanning simulations with an in-house simulation code and accurate final dose evaluations with a commercial treatment planning system.Given the similar dose evaluation criteria under a practical high scanning speed, compared with the spot scanning method, the total delivery time of the compensated raster scanning method was significantly shortened by 53.3% in the case of irradiating a cubical target and by 28.8% in a pelvic case. Therefore, it can be concluded that real-time compensated raster scanning with a fast scanning configuration can significantly shorten the delivery time compared to that of spot scanning. It is important to reduce the pressure on patients caused by prolonged immobilization and to improve patient throughput capacity at particle therapy centers.

Correction to:Shortening the delivery time of proton therapy by real-time compensation method with raster scanning

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SAPT:a synchrotron-based proton therapy facility in Shanghai

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.

Proton linac-based therapy facility for ultra-high dose rate (FLASH) treatment

As an advanced treatment method in the past five years,ultra-high dose rate(FLASH)radiotherapy as a breakthrough and milestone in radiotherapy development has been verified to be much less harmful to healthy tissues in different experiments.FLASH treatments require an instantaneous dose rate as high as hundreds of grays per second to complete the treatment in less than 100 ms.Current proton therapy facilities with the spread-out of the Bragg peak formed by different energy layers,to our knowledge,cannot easily achieve an adequate dose rate for FLASH treatments because the energy layer switch or gantry rotation of current facilities requires a few seconds,which is relatively long.A new design for a therapy facility based on a proton linear accelerator(linac)for FLASH treatment is proposed herein.It is designed under two criteria:no mechanical motion and no magnetic field variation.The new therapy facility can achieve an ultrahigh dose rate of up to 300 Gy/s;however,it delivers an instantaneous dose of 30 Gy within 100 ms to complete a typical FLASH treatment.The design includes a compact proton linac with permanent magnets,a fast beam kicker in both azimuth and elevation angles,a fixed gantry with a static superconducting coil to steer proton bunches with all energy,a fast beam scanner using radio-frequency(RF)deflectors,and a fast low-level RF system.All relevant principles and conceptual proposals are presented herein.

RF design and study of a 325 MHz 7 Me V APF IH-DTL for an injector of a proton medical accelerator

A compact interdigital H-mode drift-tube linac (IH-DTL) with the alternating-phase-focusing (APF) method, working at 325 MHz was designed for an injector of a proton medical accelerator. When fed in with a proper RF (radio frequency) power, the DTL cavity could establish the corresponding electromagnetic field to accelerate the ‘‘proton bunches’’ from an input energy of 3 MeV to an output energy of 7 MeV successfully, without any additional radial focusing elements. The gap-voltage distribution which was obtained from the CST■ Microwave Studio software simulations of the axial electric field was compared with that from the beam dynamics, and the errors met the requirements within ± 5%. In this paper, the RF design procedure and key results of the APF IH-DTL, which include the main RF characteristics of the cavity, frequency sensitivities of the tuners, and coupling factor of the RF power input coupler are presented.

Reformatted method for two-dimensional detector arrays measurement data in proton pencil beam scanning

The spatial resolution of a commercial two-dimensional(2D)ionization chamber(IC)array is limited by the size of the individual detector and the center-to-center distance between sensors.For dose distributions with areas of steep dose gradients,inter-detector dose values are derived by the interpolation of nearby detector readings in the conventional mathematical interpolation of 2D IC array measurements.This may introduce significant errors,particularly in proton spot scanning radiotherapy.In this study,by combining logfile-based reconstructed dose values and detector measurements with the Laplacian pyramid image blending method,a novel method is proposed to obtain a reformatted dose distribution that provides an improved estimation of the delivered dose distribution with high spatial resolution.Meanwhile,the similarity between the measured original data and the downsampled logfilebased reconstructed dose is regarded as the confidence of the reformatted dose distribution.Furthermore,we quantify the performance benefits of this new approach by directly comparing the reformatted dose distributions with 2D IC array detector mathematically interpolated measurements and original low-resolution measurements.The result shows that this new method is better than the mathematical interpolation and achieves gamma pass rates similar to those of the original low-resolution measurements.The reformatted dose distributions generally yield a confidence exceeding 95%.

Technical commissioning of the spot scanning system in Shanghai Proton Therapy Facility

Background In the field of particle therapy,the method of pencil beam scanning is of great potential for clinical application,now and in the future.Purpose The authors made strong effort to develop a spot scanning system for Shanghai Proton Therapy Facility.Design parameters and basic layout of the system are introduced.Methods Functionalities and specifications of crucial devices are described in detail.Most of the devices in the system were designed in house by the authors themselves,including scanning nozzle,scanning magnets and their power supplies,beam monitors,irradiation control modules and safety interlock modules.During the technical commissioning stage in the fix beam room,the spot scanning system was tested and verified.Results Under conditions of the maximum dose rate and minimum dose rate,a)repeatability of the single spot dose is less than±0.1%;b)nonlinearity of the single spot dose is less than±0.1%;c)FWHM for spot size in air at isocenter varies from 8mm to 12mm for full energy,consistent with the design values;d)lateral dose distribution achieves a flatness of less than 2%for multiple proton energies.Conclusion According to the results of technical commissioning,the spot scanning system is capable of producing a pre-scribed 3D dose distribution for target tumor successfully.