Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly understood.Magnetic resonance imaging is a non-invasive technique that has been widely u...Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly understood.Magnetic resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain injury.This approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and function.However,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional connectivity.Given that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is critical.In the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain injury.In this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy controls.Resting-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network analysis.In the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention network.More than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 patients.Furthermore,better cognitive function was associated with more efficient networks.Finally,our data indicated that small-worldness in the acute stage could serve as a predictor of longitudinal changes in connectivity in patients with mild traumatic brain injury.These findings highlight the importance of integrating structural and functional connectivity in unde rstanding the occurrence and evolution of mild traumatic brain injury.Additionally,exploratory analysis based on subnetworks could serve a predictive function in the prognosis of patients with mild traumatic brain injury.展开更多
This study proposes an image-based visual servoing(IBVS)method based on a velocity observer for an unmanned aerial vehicle(UAV)for tracking a dynamic target in Global Positioning System(GPS)-denied environments.The pr...This study proposes an image-based visual servoing(IBVS)method based on a velocity observer for an unmanned aerial vehicle(UAV)for tracking a dynamic target in Global Positioning System(GPS)-denied environments.The proposed method derives the simplified and decoupled image dynamics of underactuated UAVs using a constructed virtual camera and then considers the uncertainties caused by the unpredictable rotations and velocities of the dynamic target.A novel image depth model that extends the IBVS method to track a rotating target with arbitrary orientations is proposed.The depth model ensures image feature accuracy and image trajectory smoothness in rotating target tracking.The relative velocities of the UAV and the dynamic target are estimated using the proposed velocity observer.Thanks to the velocity observer,translational velocity measurements are not required,and the control chatter caused by noise-containing measurements is mitigated.An integral-based filter is proposed to compensate for unpredictable environmental disturbances in order to improve the antidisturbance ability.The stability of the velocity observer and IBVS controller is analyzed using the Lyapunov method.Comparative simulations and multistage experiments are conducted to illustrate the tracking stability,anti-disturbance ability,and tracking robustness of the proposed method with a dynamic rotating target.展开更多
Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsive...Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsiveness toward enforcement measures and a lack of self-regulatory approaches within companies. Purpose: The purpose of this study is to examine the implementation methods practised in Abu Dhabi with those in developed countries with established OSH regulatory bodies. Methodology: Qualitative and quantitative research methods were employed to gather primary research data. Workers from various industries in Abu Dhabi were sampled on purpose and asked to respond to questionnaires and interviews on OSH protocol awareness and implementation, and circumstances of workplace incidence. Results: The findings of this study showed that the enforcement of OSH requirements in UAE positively correlated to a reduction in the rate of work-related injury and improved business performance. The quantitative research data showed that the energy sector had the highest score (15) while the tourism sector had the lowest score (5.3) in occupational health systems and improvements in business efficiency and productivity. Implications: The outcomes of this study shed light on the importance of implementing OSH Guidelines for companies to empower their safety managers to fully enforce OSH requirements in their organisations. In conclusion, effective OSH enforcement requires cooperation between general workers and OSH managers and facilitation from business owners.展开更多
Attempts to determine characters of astronomical objects have been one of major and vibrant activities in both astronomy and data science fields.Instead of a manual inspection,various automated systems are invented to...Attempts to determine characters of astronomical objects have been one of major and vibrant activities in both astronomy and data science fields.Instead of a manual inspection,various automated systems are invented to satisfy the need,including the classification of light curve profiles.A specific Kaggle competition,namely Photometric LSST Astronomical Time-Series Classification Challenge(PLAsTiCC),is launched to gather new ideas of tackling the abovementioned task using the data set collected from the Large Synoptic Survey Telescope(LSST)project.Almost all proposed methods fall into the supervised family with a common aim to categorize each object into one of pre-defined types.As this challenge focuses on developing a predictive model that is robust to classifying unseen data,those previous attempts similarly encounter the lack of discriminate features,since distribution of training and actual test datasets are largely different.As a result,well-known classification algorithms prove to be sub-optimal,while more complicated feature extraction techniques may help to slightly boost the predictive performance.Given such a burden,this research is set to explore an unsupervised alternative to the difficult quest,where common classifiers fail to reach the 50%accuracy mark.A clustering technique is exploited to transform the space of training data,from which a more accurate classifier can be built.In addition to a single clustering framework that provides a comparable accuracy to the front runners of supervised learning,a multiple-clustering alternative is also introduced with improved performance.In fact,it is able to yield a higher accuracy rate of 58.32%from 51.36%that is obtained using a simple clustering.For this difficult problem,it is rather good considering for those achieved by well-known models like support vector machine(SVM)with 51.80%and Naive Bayes(NB)with only 2.92%.展开更多
As more business transactions and information services have been implemented via communication networks,both personal and organization assets encounter a higher risk of attacks.To safeguard these,a perimeter defence l...As more business transactions and information services have been implemented via communication networks,both personal and organization assets encounter a higher risk of attacks.To safeguard these,a perimeter defence likeNIDS(network-based intrusion detection system)can be effective for known intrusions.There has been a great deal of attention within the joint community of security and data science to improve machine-learning based NIDS such that it becomes more accurate for adversarial attacks,where obfuscation techniques are applied to disguise patterns of intrusive traffics.The current research focuses on non-payload connections at the TCP(transmission control protocol)stack level that is applicable to different network applications.In contrary to the wrapper method introduced with the benchmark dataset,three new filter models are proposed to transform the feature space without knowledge of class labels.These ECT(ensemble clustering based transformation)techniques,i.e.,ECT-Subspace,ECT-Noise and ECT-Combined,are developed using the concept of ensemble clustering and three different ensemble generation strategies,i.e.,random feature subspace,feature noise injection and their combinations.Based on the empirical study with published dataset and four classification algorithms,new models usually outperform that original wrapper and other filter alternatives found in the literature.This is similarly summarized from the first experiment with basic classification of legitimate and direct attacks,and the second that focuses on recognizing obfuscated intrusions.In addition,analysis of algorithmic parameters,i.e.,ensemble size and level of noise,is provided as a guideline for a practical use.展开更多
In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying pa...In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying parking spaces alone is insufficient because an identified available parking space may have been taken by another vehicle when it arrives,resulting in the driver’s frustration and aggravating traffic jams while searching for another parking space.This explains the need to predict the availability of parking spaces.Recently,deep learning(DL)has been shown to facilitate drivers to find parking spaces efficiently,leading to a promising performance enhancement in parking identification and prediction systems.However,no work reviews DL approaches applied to solve parking identification and prediction problems.Inspired by this gap,the purpose of this work is to investigate,highlight,and report on recent advances inDLapproaches applied to predict and identify the availability of parking spaces.Ataxonomy of DL-based parking identification and prediction systems is established as a methodology by classifying and categorizing existing literature,and by doing so,the salient and supportive features of different DL techniques for providing parking solutions are presented.Moreover,several open research challenges are outlined.This work identifies that there are various DL architectures,datasets,and performance measures used to address parking identification and prediction problems.Moreover,there are some open-source implementations available that can be used directly either to extend existing works or explore a new domain.This is the first short survey article that focuses on the use of DL-based techniques in parking identification and prediction systems for smart cities.This study concludes that although the deployment of DL in parking identification and prediction systems provides various benefits,the convergence of these two types of systems and DL brings about new issues that must be resolved in the near future.展开更多
Background Individual differences have been detected in individuals with opioid use disorders(OUD)in rehabilitation following protracted abstinence.Recent studies suggested that prediction models were effective for in...Background Individual differences have been detected in individuals with opioid use disorders(OUD)in rehabilitation following protracted abstinence.Recent studies suggested that prediction models were effective for individual-level prognosis based on neuroimage data in substance use disorders(SUD).Aims This prospective cohort study aimed to assess neuroimaging biomarkers for individual response to protracted abstinence in opioid users using connectome-based predictive modelling(CPM).Methods One hundred and eight inpatients with OUD underwent structural and functional magnetic resonance imaging(fMRI)scans at baseline.The Heroin Craving Questionnaire(HCQ)was used to assess craving levels at baseline and at the 8-month follow-up of abstinence.CPM with leave-one-out cross-validation was used to identify baseline networks that could predict follow-up HCQ scores and changes in HCQ(HCQtolow V-up-HCQpa baseline).Then,the follow-up aseline predictive ability of identified networks was tested in a separate,heterogeneous sample of methamphetamine individuals who underwent MRI scanning before abstinence for SUD.Results CPM could predict craving changes induced by long-term abstinence,as shown by a significant correlation between predicted and actual HCQ fllow-up(r=0.417,p<0.001)and changes in HCQ(negative:r=0.334,p=0.002;positive:r=0.233,p=0.038).Identified craving-related prediction networks included the somato-motor network(SMN),salience network(SALN),default mode network(DMN),medial frontal network,visual network and auditory network.In addition,decreased connectivity of frontal-parietal network(FPN)-SMN,FPN-DMN and FPN-SALN and increased connectivity of subcortical network(SCN)-DMN,SCN-SALNandSCN-SMN were positively correlated with craving levels.Conclusions These findings highlight the potential applications of CPM to predict the craving level of individuals after protracted abstinence,as well as the generalisation ability;the identified brain networks might be the focus of innovative therapies in the future.展开更多
To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth o...To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants.展开更多
Drought priming is a promising approach to improve tolerance to further drought in wheat.The root apex plays important roles in drought however,its contribution to drought priming remains unknown.To provide mechanisti...Drought priming is a promising approach to improve tolerance to further drought in wheat.The root apex plays important roles in drought however,its contribution to drought priming remains unknown.To provide mechanistic insights into this process,the transcriptomes and proteomes at three different zones along the root axis under drought stress were analyzed.Physiological assessment of root growth indicated that priming augmented roots growth in response to drought and also the levels of protective proline and glycine betaine.Scanning across the proximal to the distal zones of the root apex indicated increases the transcription of genes involved in primary and secondary metabolism.Conversely,genes related to translation,transcription,folding,sorting and degradation,replication and repair were increased in the apex compared to the proximal zone.A single drought episode suppressed their expression but prior drought priming served to maintain expression with recurrent drought stress.The differentially primed responses genes were mainly involved in the pathways related to plant hormone signaling,stress defense and cell wall modification.The prediction of regulatory hubs using Cytoscape implicated signaling components such as the ABA receptor PYL4 as influencing antioxidant status and the cell cycle.Based our integrative transcriptomic-proteomic assessments we present a model for drought priming protected plant hormone signaling transduction pathways to drive the cell cycle and cell wall loosening to confer beneficial effects on roots to counter the effects of drought.This model provides a theoretical basis for improvement of drought tolerance in wheat,via an increased understanding of drought priming induced drought tolerance.展开更多
This study was conducted to investigate the effect of a commercial essential oil (EO) additive on milk production and methane (CH4) emissions from dairy cows. Early lactation Holstein-Friesian dairy cows were fed gras...This study was conducted to investigate the effect of a commercial essential oil (EO) additive on milk production and methane (CH4) emissions from dairy cows. Early lactation Holstein-Friesian dairy cows were fed grass, whole crop wheat and corn silage total mixed ration. Cows were allocated to one of two experimental treatments: Control (no additive, CON) or 1 g/head/day of EO. Cows were housed in a free stall barn, split into two pens for the duration of the experiment. Two gas data loggers units used to measure CH4 emissions were provided per pen for the duration of the 22 week-long study. Milk yield was determined daily, and milk components were analyzed every two weeks. CH4 was recorded continuously, and daily values were tabulated. Body weight and body condition score were determined at the start and bi-weekly. Results were analyzed as a randomized complete block trial. In total, 149 cows participated in the study (76 CON, 73 EO). Milk yields were greater (P < 0.05) for the test treatment (28.3 CON, 31.2 EO) with no change in milk component concentrations. Milk component concentrations were unaffected (P > 0.05) by treatment. Yields of fat, protein, lactose, and solids were higher for EO fed cows (P 4 output was reduced with the EO compared to the CON treatment (411 g/day vs 438 g/day;13.8 g/L of milk vs 17.2 g/L of milk, P < 0.05) over the duration of the trial. There were no effects of treatment on reproductive performance or the occurrence of mastitis. Feeding EO to dairy cows reduced CH4 emissions whilst also increasing performance.展开更多
Microsatellites are highly polymorphic markers which have been used in a wide range of genetic studies.In recent years, various sources of next-generation sequencing data have been used to develop new microsatellite l...Microsatellites are highly polymorphic markers which have been used in a wide range of genetic studies.In recent years, various sources of next-generation sequencing data have been used to develop new microsatellite loci, but compared with the more common shotgun genomic sequencing or transcriptome data, the potential utility of RAD-seq data for microsatellite ascertainment is comparatively under-used.In this study, we employed MiddRAD-seq data to develop polymorphic microsatellite loci for the endangered yew species Taxus florinii. Of 8,823,053 clean reads generated for ten individuals of a population, 94,851(~1%) contained microsatellite motifs. These corresponded to 2993 unique loci, of which 526(~18%) exhibited polymorphism. Of which, 237 were suitable for designing microsatellite primer pairs, and 128 loci were randomly selected for PCR validation and microsatellite screening. Out of the 128 primer pairs, 16 loci gave clear, reproducible patterns, and were then screened and characterized in 24 individuals from two populations. The total number of alleles per locus ranged from two to ten(mean=4.875), and within-population expected heterozygosity from zero to 0.789(mean = 0.530),indicating that these microsatellite loci will be useful for population genetics and speciation studies of T. florinii. This study represents one of few examples to mine polymorphic microsatellite loci from ddRAD data.展开更多
The assessment of the fairness of health resource allocation is an important part of the study for the fairness of social development.The data used in most of the existing assessment methods comes from statistical yea...The assessment of the fairness of health resource allocation is an important part of the study for the fairness of social development.The data used in most of the existing assessment methods comes from statistical yearbooks or field survey sampling.These statistics are generally based on administrative areas and are difficult to support a fine-grained evaluation model.In response to these problems,the evaluation method proposed in this paper is based on the query statistics of the geographic grid of the target area,which are more accurate and efficient.Based on the query statistics of hot words in the geographic grids,this paper adopts the maximum likelihood estimation method to estimate the population in the grid region.Then,according to the statistical yearbook data of Hunan province,the estimated number and actual number of hospitals in each grid are analyzed and compared to measure the fairness of health resource allocation in the target region.Experiments show that the geographical grid population assessment based on hot words is more accurate and close to the actual value.The estimated average error is only about 17.8 percent.This method can assess the fairness of health resource allocation in any scale,and is innovative in data acquisition and evaluation methods.展开更多
Titanium germanium intermetallics (TixGey)were directly prepared from titanium oxide (TiO2) and germanium oxide(GeO2) powders mixture by using an electrodeoxidation process. The electrochemical experiment was ca...Titanium germanium intermetallics (TixGey)were directly prepared from titanium oxide (TiO2) and germanium oxide(GeO2) powders mixture by using an electrodeoxidation process. The electrochemical experiment was carried out in a molten fluxCaCl2-NaCl at 800℃ with a potential of 3.0 V. The results show that monolithic germanide Ti5Ge3 intermetallic can be directlyproduced from TiO2-GeO2 or CaTiO3-GeO2 precursors (both molar ratios are 5:3), and the obtained Ti5Ge3 powders exhibithomogenous particle structure. In addition, the phase composition of the final product can be dramatically affected by the initialmolar ratio of TiO2 to GeO2. The reaction mechanism of the electrodeoxidation process was discussed based on the experimentalresults. It is suggested that the electrodeoxidation process is an environmentally friendly method for the preparation of Ti-Geintermetallics.展开更多
Ion pickup by a monochromatic low-frequency Alfv6n wave, which propagates along the background magnetic field, has recently been investigated in a low beta plasma (Lu and Li 2007 Phys. Plasmas 14 042303). In this pa...Ion pickup by a monochromatic low-frequency Alfv6n wave, which propagates along the background magnetic field, has recently been investigated in a low beta plasma (Lu and Li 2007 Phys. Plasmas 14 042303). In this paper, the monochromatic Alfven wave is generalized to a spectrum of Alfven waves with random phase. It finds that the process of ion pickup can be divided into two stages. First, ions are picked up in the transverse direction, and then phase difference (randomization) between ions due to their different parallel thermal motions leads to heating of the ions. The heating is dominant in the direction perpendicular to the background magnetic field. The temperatures of the ions at the asymptotic stage do not depend on individual waves in the spectrum, but are determined by the total amplitude of the waves. The effect of the initial ion bulk flow in the parallel direction on the heating is also considered in this paper.展开更多
There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-cha...There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-channel chemical sensor to detect such anomalies which can be used in deep-sea at depths of more than 4 000 m. The design allowed five all-solid-state electrodes to be mounted on it and each (apart from one reference electrode) could be changed according to chemicals to be measured. Two experiments were conducted using the chemical sensors. The first was a shallow-sea trial which included sample measurements and in situ monitoring. pH, Eh, CO3^2- and SO4^2- electrodes were utilized to demonstrate that the chemical sensor was accurate and stable outside the laboratory. In the second experiment, the chemical sensor was integrated with pH, Eh, CO3^2- and H2S electrodes, and was used in 29 scans of the seabed along the Southwest Indian Ridge (SWIR) to detect hydrothermal vents, from which 27 sets of valid data were obtained. Hydrothermal vents were identified by analyzing the chemical anomalies, the primary judging criteria were decreasing voltages of Eh and H2S, matched by increasing voltages of pH and CO3^2- . We proposed that simultaneous detection of changes in these parameters will indicate a hydrothermal vent. Amongst the 27 valid sets of data, five potential hydrothermal vents were targeted using the proposed method. We suggest that our sensors could be widely employed by marine scientists.展开更多
The present study compared eight breeds of cattle differing in gender (heifers, buls and steers) to determine associations between muscle characteristics and meat sensory qualities of theLongissimus thoracis muscle....The present study compared eight breeds of cattle differing in gender (heifers, buls and steers) to determine associations between muscle characteristics and meat sensory qualities of theLongissimus thoracis muscle. Animal types differed in al the muscle characteristics and sensory qualities. Many correlations among muscle characteristics and among sensory qualities were consistent for most animal types. Isocitrate dehydrogenase (ICDH) activities alowed discrimination of muscles with respect to myosin heavy chain (MyHC)-I proportions for al animal types. Lactate dehydrogenase (LDH) and phos-phofructokinase (PFK) activities were positively correlated for most animal types. Overal liking was correlated with beef lfavour and abnormal lfavour in al animal types and with global tenderness for al animal types except for Charolais cross breed steers. For al animal types except for Angus×Friesian heifers, beef lfavour and abnormal lfavour were negatively correlated. Overal liking was not correlated with juiciness. PFK, ICDH and citrate synthase (CS) activities were strongly associated with tenderness, beef lfavour and overal liking when average values for al animal types were used. However, associations between muscle characteristics and sensory qualities within animal types were weak and inconsistent.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81671671(to JL),61971451(to JL),U22A2034(to XK),62177047(to XK)the National Defense Science and Technology Collaborative Innovation Major Project of Central South University,No.2021gfcx05(to JL)+6 种基金Clinical Research Cen terfor Medical Imaging of Hunan Province,No.2020SK4001(to JL)Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection of Hu nan Province,No.2020SK3006(to JL)Innovative Special Construction Foundation of Hunan Province,No.2019SK2131(to JL)the Science and Technology lnnovation Program of Hunan Province,Nos.2021RC4016(to JL),2021SK53503(to ML)Scientific Research Program of Hunan Commission of Health,No.202209044797(to JL)Central South University Research Program of Advanced Interdisciplinary Studies,No.2023Q YJC020(to XK)the Natural Science Foundation of Hunan Province,No.2022JJ30814(to ML)。
文摘Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly understood.Magnetic resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain injury.This approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and function.However,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional connectivity.Given that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is critical.In the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain injury.In this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy controls.Resting-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network analysis.In the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention network.More than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 patients.Furthermore,better cognitive function was associated with more efficient networks.Finally,our data indicated that small-worldness in the acute stage could serve as a predictor of longitudinal changes in connectivity in patients with mild traumatic brain injury.These findings highlight the importance of integrating structural and functional connectivity in unde rstanding the occurrence and evolution of mild traumatic brain injury.Additionally,exploratory analysis based on subnetworks could serve a predictive function in the prognosis of patients with mild traumatic brain injury.
基金supported in part by the National Key Research and Development Program of China(2021ZD0114503,2022YFB4701800,and 2021YFB1714700)the National Natural Science Foundation of China(62273098,62027810,61971071,62133005,62273138,and 62103140)+9 种基金the Major Research Plan of the National Natural Science Foundation of China(92148204)the Newton International Fellowships 2022 funded by the Royal Society,UK(NIF\R1\221089)Hunan Leading Talent of Technological Innovation(2022RC3063)Hunan Science Fund for Distinguished Young Scholars(2021JJ10025)the Hunan Key Research and Development Program(2021GK4011 and 2022GK2011)the Changsha Science and Technology Major Project(kh2003026)the Natural Science Foundation of Hunan Province(2021JJ20029 and 2021JJ40124)the Science and Technology Innovation Program of Hunan Province(2021RC3060)the Joint Open Foundation of the State Key Laboratory of Robotics(2021-KF-22-17)the China University Industry-University-Research Innovation Fund(2020HYA06006).
文摘This study proposes an image-based visual servoing(IBVS)method based on a velocity observer for an unmanned aerial vehicle(UAV)for tracking a dynamic target in Global Positioning System(GPS)-denied environments.The proposed method derives the simplified and decoupled image dynamics of underactuated UAVs using a constructed virtual camera and then considers the uncertainties caused by the unpredictable rotations and velocities of the dynamic target.A novel image depth model that extends the IBVS method to track a rotating target with arbitrary orientations is proposed.The depth model ensures image feature accuracy and image trajectory smoothness in rotating target tracking.The relative velocities of the UAV and the dynamic target are estimated using the proposed velocity observer.Thanks to the velocity observer,translational velocity measurements are not required,and the control chatter caused by noise-containing measurements is mitigated.An integral-based filter is proposed to compensate for unpredictable environmental disturbances in order to improve the antidisturbance ability.The stability of the velocity observer and IBVS controller is analyzed using the Lyapunov method.Comparative simulations and multistage experiments are conducted to illustrate the tracking stability,anti-disturbance ability,and tracking robustness of the proposed method with a dynamic rotating target.
文摘Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsiveness toward enforcement measures and a lack of self-regulatory approaches within companies. Purpose: The purpose of this study is to examine the implementation methods practised in Abu Dhabi with those in developed countries with established OSH regulatory bodies. Methodology: Qualitative and quantitative research methods were employed to gather primary research data. Workers from various industries in Abu Dhabi were sampled on purpose and asked to respond to questionnaires and interviews on OSH protocol awareness and implementation, and circumstances of workplace incidence. Results: The findings of this study showed that the enforcement of OSH requirements in UAE positively correlated to a reduction in the rate of work-related injury and improved business performance. The quantitative research data showed that the energy sector had the highest score (15) while the tourism sector had the lowest score (5.3) in occupational health systems and improvements in business efficiency and productivity. Implications: The outcomes of this study shed light on the importance of implementing OSH Guidelines for companies to empower their safety managers to fully enforce OSH requirements in their organisations. In conclusion, effective OSH enforcement requires cooperation between general workers and OSH managers and facilitation from business owners.
基金funded by the Security BigData Fusion Project(Office of theMinistry of Higher Education,Science,Research and Innovation).The corresponding author is the project PI.
文摘Attempts to determine characters of astronomical objects have been one of major and vibrant activities in both astronomy and data science fields.Instead of a manual inspection,various automated systems are invented to satisfy the need,including the classification of light curve profiles.A specific Kaggle competition,namely Photometric LSST Astronomical Time-Series Classification Challenge(PLAsTiCC),is launched to gather new ideas of tackling the abovementioned task using the data set collected from the Large Synoptic Survey Telescope(LSST)project.Almost all proposed methods fall into the supervised family with a common aim to categorize each object into one of pre-defined types.As this challenge focuses on developing a predictive model that is robust to classifying unseen data,those previous attempts similarly encounter the lack of discriminate features,since distribution of training and actual test datasets are largely different.As a result,well-known classification algorithms prove to be sub-optimal,while more complicated feature extraction techniques may help to slightly boost the predictive performance.Given such a burden,this research is set to explore an unsupervised alternative to the difficult quest,where common classifiers fail to reach the 50%accuracy mark.A clustering technique is exploited to transform the space of training data,from which a more accurate classifier can be built.In addition to a single clustering framework that provides a comparable accuracy to the front runners of supervised learning,a multiple-clustering alternative is also introduced with improved performance.In fact,it is able to yield a higher accuracy rate of 58.32%from 51.36%that is obtained using a simple clustering.For this difficult problem,it is rather good considering for those achieved by well-known models like support vector machine(SVM)with 51.80%and Naive Bayes(NB)with only 2.92%.
文摘As more business transactions and information services have been implemented via communication networks,both personal and organization assets encounter a higher risk of attacks.To safeguard these,a perimeter defence likeNIDS(network-based intrusion detection system)can be effective for known intrusions.There has been a great deal of attention within the joint community of security and data science to improve machine-learning based NIDS such that it becomes more accurate for adversarial attacks,where obfuscation techniques are applied to disguise patterns of intrusive traffics.The current research focuses on non-payload connections at the TCP(transmission control protocol)stack level that is applicable to different network applications.In contrary to the wrapper method introduced with the benchmark dataset,three new filter models are proposed to transform the feature space without knowledge of class labels.These ECT(ensemble clustering based transformation)techniques,i.e.,ECT-Subspace,ECT-Noise and ECT-Combined,are developed using the concept of ensemble clustering and three different ensemble generation strategies,i.e.,random feature subspace,feature noise injection and their combinations.Based on the empirical study with published dataset and four classification algorithms,new models usually outperform that original wrapper and other filter alternatives found in the literature.This is similarly summarized from the first experiment with basic classification of legitimate and direct attacks,and the second that focuses on recognizing obfuscated intrusions.In addition,analysis of algorithmic parameters,i.e.,ensemble size and level of noise,is provided as a guideline for a practical use.
文摘In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying parking spaces alone is insufficient because an identified available parking space may have been taken by another vehicle when it arrives,resulting in the driver’s frustration and aggravating traffic jams while searching for another parking space.This explains the need to predict the availability of parking spaces.Recently,deep learning(DL)has been shown to facilitate drivers to find parking spaces efficiently,leading to a promising performance enhancement in parking identification and prediction systems.However,no work reviews DL approaches applied to solve parking identification and prediction problems.Inspired by this gap,the purpose of this work is to investigate,highlight,and report on recent advances inDLapproaches applied to predict and identify the availability of parking spaces.Ataxonomy of DL-based parking identification and prediction systems is established as a methodology by classifying and categorizing existing literature,and by doing so,the salient and supportive features of different DL techniques for providing parking solutions are presented.Moreover,several open research challenges are outlined.This work identifies that there are various DL architectures,datasets,and performance measures used to address parking identification and prediction problems.Moreover,there are some open-source implementations available that can be used directly either to extend existing works or explore a new domain.This is the first short survey article that focuses on the use of DL-based techniques in parking identification and prediction systems for smart cities.This study concludes that although the deployment of DL in parking identification and prediction systems provides various benefits,the convergence of these two types of systems and DL brings about new issues that must be resolved in the near future.
文摘Background Individual differences have been detected in individuals with opioid use disorders(OUD)in rehabilitation following protracted abstinence.Recent studies suggested that prediction models were effective for individual-level prognosis based on neuroimage data in substance use disorders(SUD).Aims This prospective cohort study aimed to assess neuroimaging biomarkers for individual response to protracted abstinence in opioid users using connectome-based predictive modelling(CPM).Methods One hundred and eight inpatients with OUD underwent structural and functional magnetic resonance imaging(fMRI)scans at baseline.The Heroin Craving Questionnaire(HCQ)was used to assess craving levels at baseline and at the 8-month follow-up of abstinence.CPM with leave-one-out cross-validation was used to identify baseline networks that could predict follow-up HCQ scores and changes in HCQ(HCQtolow V-up-HCQpa baseline).Then,the follow-up aseline predictive ability of identified networks was tested in a separate,heterogeneous sample of methamphetamine individuals who underwent MRI scanning before abstinence for SUD.Results CPM could predict craving changes induced by long-term abstinence,as shown by a significant correlation between predicted and actual HCQ fllow-up(r=0.417,p<0.001)and changes in HCQ(negative:r=0.334,p=0.002;positive:r=0.233,p=0.038).Identified craving-related prediction networks included the somato-motor network(SMN),salience network(SALN),default mode network(DMN),medial frontal network,visual network and auditory network.In addition,decreased connectivity of frontal-parietal network(FPN)-SMN,FPN-DMN and FPN-SALN and increased connectivity of subcortical network(SCN)-DMN,SCN-SALNandSCN-SMN were positively correlated with craving levels.Conclusions These findings highlight the potential applications of CPM to predict the craving level of individuals after protracted abstinence,as well as the generalisation ability;the identified brain networks might be the focus of innovative therapies in the future.
基金financial support provided under the Network Project of ICAR on ‘VTCC’ to carry the research further in this direction
文摘To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants.
基金supported by the National Key Research and Development Program of China (2016YFD0300107)the National Natural Science Foundation of China (31771693, U1803235)+3 种基金the China Agriculture Research System (CARS-03)JCIC-MCPthe 111 Project (B16026)the UK Biotechnology and Biological Sciences Research Council (BBSRC) Exchange Grant (BB/R02118X/1)。
文摘Drought priming is a promising approach to improve tolerance to further drought in wheat.The root apex plays important roles in drought however,its contribution to drought priming remains unknown.To provide mechanistic insights into this process,the transcriptomes and proteomes at three different zones along the root axis under drought stress were analyzed.Physiological assessment of root growth indicated that priming augmented roots growth in response to drought and also the levels of protective proline and glycine betaine.Scanning across the proximal to the distal zones of the root apex indicated increases the transcription of genes involved in primary and secondary metabolism.Conversely,genes related to translation,transcription,folding,sorting and degradation,replication and repair were increased in the apex compared to the proximal zone.A single drought episode suppressed their expression but prior drought priming served to maintain expression with recurrent drought stress.The differentially primed responses genes were mainly involved in the pathways related to plant hormone signaling,stress defense and cell wall modification.The prediction of regulatory hubs using Cytoscape implicated signaling components such as the ABA receptor PYL4 as influencing antioxidant status and the cell cycle.Based our integrative transcriptomic-proteomic assessments we present a model for drought priming protected plant hormone signaling transduction pathways to drive the cell cycle and cell wall loosening to confer beneficial effects on roots to counter the effects of drought.This model provides a theoretical basis for improvement of drought tolerance in wheat,via an increased understanding of drought priming induced drought tolerance.
文摘This study was conducted to investigate the effect of a commercial essential oil (EO) additive on milk production and methane (CH4) emissions from dairy cows. Early lactation Holstein-Friesian dairy cows were fed grass, whole crop wheat and corn silage total mixed ration. Cows were allocated to one of two experimental treatments: Control (no additive, CON) or 1 g/head/day of EO. Cows were housed in a free stall barn, split into two pens for the duration of the experiment. Two gas data loggers units used to measure CH4 emissions were provided per pen for the duration of the 22 week-long study. Milk yield was determined daily, and milk components were analyzed every two weeks. CH4 was recorded continuously, and daily values were tabulated. Body weight and body condition score were determined at the start and bi-weekly. Results were analyzed as a randomized complete block trial. In total, 149 cows participated in the study (76 CON, 73 EO). Milk yields were greater (P < 0.05) for the test treatment (28.3 CON, 31.2 EO) with no change in milk component concentrations. Milk component concentrations were unaffected (P > 0.05) by treatment. Yields of fat, protein, lactose, and solids were higher for EO fed cows (P 4 output was reduced with the EO compared to the CON treatment (411 g/day vs 438 g/day;13.8 g/L of milk vs 17.2 g/L of milk, P < 0.05) over the duration of the trial. There were no effects of treatment on reproductive performance or the occurrence of mastitis. Feeding EO to dairy cows reduced CH4 emissions whilst also increasing performance.
基金funded by the National Natural Science Foundations of China (31370252, 41571059)the National Key Basic Research Program of China (2014CB954100)supported by the China Scholarship Council for one-year study at the Aberystwyth University,UK
文摘Microsatellites are highly polymorphic markers which have been used in a wide range of genetic studies.In recent years, various sources of next-generation sequencing data have been used to develop new microsatellite loci, but compared with the more common shotgun genomic sequencing or transcriptome data, the potential utility of RAD-seq data for microsatellite ascertainment is comparatively under-used.In this study, we employed MiddRAD-seq data to develop polymorphic microsatellite loci for the endangered yew species Taxus florinii. Of 8,823,053 clean reads generated for ten individuals of a population, 94,851(~1%) contained microsatellite motifs. These corresponded to 2993 unique loci, of which 526(~18%) exhibited polymorphism. Of which, 237 were suitable for designing microsatellite primer pairs, and 128 loci were randomly selected for PCR validation and microsatellite screening. Out of the 128 primer pairs, 16 loci gave clear, reproducible patterns, and were then screened and characterized in 24 individuals from two populations. The total number of alleles per locus ranged from two to ten(mean=4.875), and within-population expected heterozygosity from zero to 0.789(mean = 0.530),indicating that these microsatellite loci will be useful for population genetics and speciation studies of T. florinii. This study represents one of few examples to mine polymorphic microsatellite loci from ddRAD data.
文摘The assessment of the fairness of health resource allocation is an important part of the study for the fairness of social development.The data used in most of the existing assessment methods comes from statistical yearbooks or field survey sampling.These statistics are generally based on administrative areas and are difficult to support a fine-grained evaluation model.In response to these problems,the evaluation method proposed in this paper is based on the query statistics of the geographic grid of the target area,which are more accurate and efficient.Based on the query statistics of hot words in the geographic grids,this paper adopts the maximum likelihood estimation method to estimate the population in the grid region.Then,according to the statistical yearbook data of Hunan province,the estimated number and actual number of hospitals in each grid are analyzed and compared to measure the fairness of health resource allocation in the target region.Experiments show that the geographical grid population assessment based on hot words is more accurate and close to the actual value.The estimated average error is only about 17.8 percent.This method can assess the fairness of health resource allocation in any scale,and is innovative in data acquisition and evaluation methods.
基金Project(51574164)supported by the National Natural Science Foundation of ChinaProject(2014CB643403)supported by the National Basic Research Program of China
文摘Titanium germanium intermetallics (TixGey)were directly prepared from titanium oxide (TiO2) and germanium oxide(GeO2) powders mixture by using an electrodeoxidation process. The electrochemical experiment was carried out in a molten fluxCaCl2-NaCl at 800℃ with a potential of 3.0 V. The results show that monolithic germanide Ti5Ge3 intermetallic can be directlyproduced from TiO2-GeO2 or CaTiO3-GeO2 precursors (both molar ratios are 5:3), and the obtained Ti5Ge3 powders exhibithomogenous particle structure. In addition, the phase composition of the final product can be dramatically affected by the initialmolar ratio of TiO2 to GeO2. The reaction mechanism of the electrodeoxidation process was discussed based on the experimentalresults. It is suggested that the electrodeoxidation process is an environmentally friendly method for the preparation of Ti-Geintermetallics.
基金supported by the National Natural Science Foundation of China(Grants Nos 40725013 and 40674093)Chinese Academy of Sciences(Grant No KJCX2-YW-N28 9140C08060507ZCZJ19)
文摘Ion pickup by a monochromatic low-frequency Alfv6n wave, which propagates along the background magnetic field, has recently been investigated in a low beta plasma (Lu and Li 2007 Phys. Plasmas 14 042303). In this paper, the monochromatic Alfven wave is generalized to a spectrum of Alfven waves with random phase. It finds that the process of ion pickup can be divided into two stages. First, ions are picked up in the transverse direction, and then phase difference (randomization) between ions due to their different parallel thermal motions leads to heating of the ions. The heating is dominant in the direction perpendicular to the background magnetic field. The temperatures of the ions at the asymptotic stage do not depend on individual waves in the spectrum, but are determined by the total amplitude of the waves. The effect of the initial ion bulk flow in the parallel direction on the heating is also considered in this paper.
基金The Open Foundation of Laboratory of Marine Ecosystem and Biogeochemistry,SOA under contract No.LMEB201701
文摘There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-channel chemical sensor to detect such anomalies which can be used in deep-sea at depths of more than 4 000 m. The design allowed five all-solid-state electrodes to be mounted on it and each (apart from one reference electrode) could be changed according to chemicals to be measured. Two experiments were conducted using the chemical sensors. The first was a shallow-sea trial which included sample measurements and in situ monitoring. pH, Eh, CO3^2- and SO4^2- electrodes were utilized to demonstrate that the chemical sensor was accurate and stable outside the laboratory. In the second experiment, the chemical sensor was integrated with pH, Eh, CO3^2- and H2S electrodes, and was used in 29 scans of the seabed along the Southwest Indian Ridge (SWIR) to detect hydrothermal vents, from which 27 sets of valid data were obtained. Hydrothermal vents were identified by analyzing the chemical anomalies, the primary judging criteria were decreasing voltages of Eh and H2S, matched by increasing voltages of pH and CO3^2- . We proposed that simultaneous detection of changes in these parameters will indicate a hydrothermal vent. Amongst the 27 valid sets of data, five potential hydrothermal vents were targeted using the proposed method. We suggest that our sensors could be widely employed by marine scientists.
基金the framework of the EU Project ProSafeBeef(FOOD-CT-2006-36241)with INRA(Institut National de la Recherche Agronomique,France)Quality Assurance number AQ284
文摘The present study compared eight breeds of cattle differing in gender (heifers, buls and steers) to determine associations between muscle characteristics and meat sensory qualities of theLongissimus thoracis muscle. Animal types differed in al the muscle characteristics and sensory qualities. Many correlations among muscle characteristics and among sensory qualities were consistent for most animal types. Isocitrate dehydrogenase (ICDH) activities alowed discrimination of muscles with respect to myosin heavy chain (MyHC)-I proportions for al animal types. Lactate dehydrogenase (LDH) and phos-phofructokinase (PFK) activities were positively correlated for most animal types. Overal liking was correlated with beef lfavour and abnormal lfavour in al animal types and with global tenderness for al animal types except for Charolais cross breed steers. For al animal types except for Angus×Friesian heifers, beef lfavour and abnormal lfavour were negatively correlated. Overal liking was not correlated with juiciness. PFK, ICDH and citrate synthase (CS) activities were strongly associated with tenderness, beef lfavour and overal liking when average values for al animal types were used. However, associations between muscle characteristics and sensory qualities within animal types were weak and inconsistent.