Research progress on the drug action and resistance mechanism in Mycobacterium tuberculosis

Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium Tuberculosis(MTB).It is the second largest single cause of death besides novel coronavirus pneumonia.Along with the abuse of antibiotics and extensive use of anti-tuberculosis drugs,multidrug-resistant(MDR)TB,drug-resistant(XDR)TB and totally drug-resistant(TDR)TB became obstacles to the tuberculosis eradication worldwide.According to the World Health Organization(WHO)statistics,China is not only a high burden tuberculosis country in the world,but also a country with a serious epidemic of MDR.Traditional drugs fail to meet the needs of tuberculosis control.Therefore,it is urgent to find new targets of anti-tuberculosis drugs and develop new anti-tuberculosis drugs.Hence,this paper systematically summarizes the mechanism of traditional and newly developed anti-tuberculosis drugs,in which stressing the research progress of drug resistance mechanisms.This work provides us with new insights of new anti-tuberculosis drug developments,and may contribute to a reduction in the harm that tuberculosis brings to society.

Research on Water Resources Conservation of Mountain River Based on the Concept of Region Partition

Presently concepts and methods related to water resources conservation of mountain rivers are seriously insufficient,and its level is far from being adaptable to the development of a harmonious society.As mountain ecosystems play a key role in water resources conservation of mountain rivers,and the characteristics of mountain ecosystems and hydrologic features of mountain river follow strong temporal and spatial distribution,partition theory can be applied to the water resources conservation of mountain river.This theory observes the following partition principles:regional relativity,spatial continuity,integralcounty,meeting management needs,hierarchical principle,and comparability principle.And it lays equal emphasis on both water resources conservation and environmental protection,on both water quality conservation and water quantity protection,on the combination of water features,water cycle and water pollution.In the partition methods,index method and map superposition method will be applied in region partition.The example of region partition of water resources conservation in the upper reaches of the Yangtze River shows that the partition theory is practicable in water resources conservation of mountain rivers,and it provides a platform for future study in water resources conservation.

Research Progress of Catalysts and Initiators for Promoting the Cracking of Endothermic Hydrocarbon Fuels

Catalytic/initiated cracking of endothermic hydrocarbon fuels is an eff ective technology for cooling a hypersonic aircraft with a high Mach number(over 5).Catalysts and initiators can promote fuel cracking at low temperatures,increase fuel conversion and the heat sink capacity,and suppress coke deposition,thereby reducing waste heat.Catalysts mainly include metal oxide catalysts,noble metal catalysts and metal nanoparticles,zeolite catalysts,nanozeolite catalysts,and coating catalysts.Moreover,initiators roughly include nitrogenous compounds,oxygenated compounds,and hyperbranched polymer initiators.In this review,we aim to summarize the catalysts and initiators for cracking endothermic hydrocarbon fuels and their mechanisms for promoting cracking.This review will facilitate the development of the synthesis and exploration of catalysts and initiators.