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Anti-hyperlipidaemic assay and LC-MS/MS determination of piperinic ester in rat
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作者 Bo Surina Dan Mu +1 位作者 Ochir Sarangua Chunjie Ma 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2018年第12期840-846,共7页
In the present study, we aimed to establish high-fat diet model for evaluating anti-hyperlipidaemic activity of GBA and to establish the HPLC-MS method for measuring the pharmacokinetics of GBA in rat blood plasma and... In the present study, we aimed to establish high-fat diet model for evaluating anti-hyperlipidaemic activity of GBA and to establish the HPLC-MS method for measuring the pharmacokinetics of GBA in rat blood plasma and liver after oral administration. Rats were orally administrated with GBA at the dose of 50mg/kg body weight. GBA concentrations in blood plasma and liver were detected by HPLC from 0.5–10 h post administrations. The pharmacokinetic parameters were analyzed by the DAS1.0Software. The concentration-time curves of the plasma GBA and liver GBA wereconformed to two-compartment model. GBA was rapidly absorbed in the gastrointestinal tract and could be detected in plasma and liver 0.5 h after oral administration. 展开更多
关键词 Long pepper Piperinic ester GBA Antihyperlipidaemic activity LC-MS/MS analysis
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