Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S‑100 Nanofbrous Mats for the Intestinal Drug Delivery

Metronidazole(MTZ)loaded Eudragit S-100(ES-100)nonwoven nanofbrous mats were successfully electrospun and evaluated for intestinal drug delivery.MTZ was varied in the range of 1–15%(w/w)in ES-100 nanofbrous mats,the morphological characterization of nanofbrous mats was carried out using FE-SEM and the average diameter of nanofber was found in the range 150–600 nm.WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofbrous mats.Their contact angle analysis confrmed the hydrophobic nature.The mechanical strength of ES-100 nanofbrous mats decreased with increasing MTZ concentration.The drug release profles showed 74%MTZ release from ES-100d within 2 h at pH 6.8 which is the colonic environment.Antibacterial activities against gram-positive bacteria(Staphylococcus aureus)and gramnegative bacteria(Escherichia coli)showed that the ES-100 nanofbrous mats loaded with MTZ exhibited good activity.

Statistical optimization and formulation of microalga cultivation medium for improved omega 3 fatty acid production

Microalgae are considered a rich source of high-value metabolites with an array of nutraceutical and pharmaceutical applications.Diferent strategies have been developed for cultivating microalgae at large-scale photobioreactors but high cost and low productivity are the major hurdles.Optimizing the composition of media for the cultivation of microalgae to induce biomass production and high-value metabolite accumulation has been considered as an important factor for sustainable product development.In this study,the efect of plant growth regulators together with basal microalgal cultivation medium on biomass,total lipid,and EPA production was studied using the Plackett–Burman model and Response surface methodology.The traditional one-factor-at-a-time optimization approach is laborious,time-consuming,and requires more experiments which makes the process and analysis more difcult.The Designed PB model was found to be signifcant for biomass(396 mg/L),lipid(254 mg/L),and EPA(5.6%)production with a P value<0.05.The major objective of this study is to formulate a medium for EPA production without compromising the growth properties.Further,we had formulated a new media using RSM to achieve the goal and the signifcant variables selected were NaNO_(3),NaH_(2)PO_(4),and IAA and was found to be signifcant with 16.72%EPA production with a biomass production of 893 mg/L with a P value<0.05.The formulated medium can be used in large-scale cultivation systems which can enhance biomass production as well as the omega 3 fatty acid production in marine microalgae Nannochloropsis oceanica.

Blue emitting exciplex for yellow and white organic light‑emitting diodes

White organic light-emitting diodes(WOLEDs)have several desirable features,but their commercialization is hindered by the poor stability of blue light emitters and high production costs due to complicated device structures.Herein,we investigate a standard blue emitting hole transporting material(HTM)N,N'-bis(naphthalen-1-yl)-N,N'-bis(phenyl)benzidine(NPB)and its exciplex emission upon combining with a suitable electron transporting material(ETM),3-(biphenyl-4-yl)-5-(4-tert-butylphenyl)-4-phenyl-4H-1,2,4-triazole(TAZ).Blue and yellow OLEDs with simple device structures are developed by using a blend layer,NPB:TAZ,as a blue emitter as well as a host for yellow phosphorescent dopant iridium(III)bis(4-phenylthieno[3,2-c]pyridinato-N,C2')acetylacetonate(PO-01).Strategic device design then exploits the ambipolar charge transport properties of tetracene as a spacer layer to connect these blue and yellow emitting units.The tetracene-linked device demonstrates more promising results compared to those using a conventional charge generation layer(CGL).Judicious choice of the spacer prevents exciton difusion from the blue emitter unit,yet facilitates charge carrier transport to the yellow emitter unit to enable additional exciplex formation.This complementary behavior of the spacer improves the blue emission properties concomitantly yielding reasonable yellow emission.The overall white light emission properties are enhanced,achieving CIE coordinates(0.36,0.39)and color temperature(4643 K)similar to daylight.Employing intermolecular exciplex emission in OLEDs simplifes the device architecture via its dual functionality as a host and as an emitter.