Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM ...Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology,pathogenesis,diagnosis,and treatment.Western medicine and TCM each has its own theoretical system.Each has its own exposition in explaining the etiology and pathogenesis of the disease,and each has its own characteristics and advantages in diagnosis and treatment.Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.展开更多
Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the cont...Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the control group,the OIRN group,and the EA(OIPN+EA)group,with 10 rats in each.The time courses of mechanical,cold sensitivity,and microcirculation blood flow intensity were determined.The morphology of the dorsal root ganglion(DRG)was observed by electron microscopic examination.The protein levels of nuclear factor E2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the transient receptor potential(TRP)protein family in DRGs were assayed by Western blot.Results:EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats(P<0.01).Notably,oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs(P<0.01).EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin(P<0.01).In addition,the expression levels of Nrf2 and HO-1 were down-regulated,and the TRP protein family was over-expressed in the DRGs of OIPN rats(P<0.01).EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG(P<0.05 or P<0.01).Conclusion:EA may be a potential alternative therapy for OIPN,and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.展开更多
基金2018 Shanghai Leading Talents Training ProgramShanghai Clinical Research Center for Acupuncture and Moxibustion Accelerating(No.20MC1920500)+1 种基金the Development of Chinese Medicine Three-Year Action Plan of Shanghai(No.ZY(2018-2020)-CCCX-2004-04)Clinical Key Specialty Construction Foundation of Shanghai(No.shslczdzk04701).
文摘Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology,pathogenesis,diagnosis,and treatment.Western medicine and TCM each has its own theoretical system.Each has its own exposition in explaining the etiology and pathogenesis of the disease,and each has its own characteristics and advantages in diagnosis and treatment.Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.
基金Supported by the National Natural Science Foundation of China(No.81874506)the Shanghai Clinical Research Center for Acupuncture and Moxibustion(No.20MC1920500)。
文摘Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the control group,the OIRN group,and the EA(OIPN+EA)group,with 10 rats in each.The time courses of mechanical,cold sensitivity,and microcirculation blood flow intensity were determined.The morphology of the dorsal root ganglion(DRG)was observed by electron microscopic examination.The protein levels of nuclear factor E2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the transient receptor potential(TRP)protein family in DRGs were assayed by Western blot.Results:EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats(P<0.01).Notably,oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs(P<0.01).EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin(P<0.01).In addition,the expression levels of Nrf2 and HO-1 were down-regulated,and the TRP protein family was over-expressed in the DRGs of OIPN rats(P<0.01).EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG(P<0.05 or P<0.01).Conclusion:EA may be a potential alternative therapy for OIPN,and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.