Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasom...Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and inflammation.This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an ASM inhibitor,on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway.Methods:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD model.The cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-αgroup.Intracellular lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified ASM,NLRP3,and caspase 1 protein expression.Enzyme linked immunosorbent assay(ELISA)was measured CE and ASM levels,while qRT-PCR assessed mRNA expression.The apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in ASM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these indicators.Ami demonstrated a reduction in lipid deposition,suppressed ASM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved apoptosis.Additionally,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell model.Conclusion:The ASM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell damage.Ami emerges as a promising therapeutic agent by inhibiting the ASM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.展开更多
Nuclear medicine plays an irreplaceable role in the diagnosis and treatment of tumors.Radiopharmaceuticals are important components of nuclear medicine.Among the radiopharmaceuticals approved by the Food and Drug Admi...Nuclear medicine plays an irreplaceable role in the diagnosis and treatment of tumors.Radiopharmaceuticals are important components of nuclear medicine.Among the radiopharmaceuticals approved by the Food and Drug Administration(FDA),radio-tracers targeting prostate-specific membrane antigen(PSMA)and somatostatin receptor(SSTR)have held essential positions in the diagnosis and treatment of prostate cancers and neuroendocrine neoplasms,respectively.In recent years,FDA-approved serials of immune-therapy and targeted therapy drugs targeting programmed death 1(PD-1)/programmed death ligand 1(PD-L1),human epidermal growth factor receptor 2(HER2),and nectin cell adhesion molecule 4(Nectin 4).How to screen patients suitable for these treatments and monitor the therapy?Nuclear medicine with specific radiopharmaceuticals can visualize the expression level of those targets in systemic lesions and evaluate the efficacy of treatment.In addition to radiopharmaceuticals,imaging equipment is also a key step for nuclear medicine.Advanced equipment including total-body positron emission tomography/computed tomography(PET/CT)and positron emission tomography/magnetic resonance imaging(PET/MRI)has been developed,which contribute to the diagnosis and treatment of tumors,as well as the development of new radiopharmaceuticals.Here,we conclude most recently advances of radiopharmaceuticals in nuclear medicine,and they substantially increase the“arsenal”of clinicians for tumor therapy.展开更多
Objectives:This study aimed to assess the nurses’knowledge and compliance with infection control standard precautions and evaluate the impact of the designed infection control educational program on nurses’knowledge...Objectives:This study aimed to assess the nurses’knowledge and compliance with infection control standard precautions and evaluate the impact of the designed infection control educational program on nurses’knowledge and compliance with standard precautions at the maternity hospital.Materials and Methods:A quasi‑experimental one‑group pretest‑posttest design was used on convenient sample of 60 nurses working at Obstetrics and Gynecological hospital in Cairo University Hospital,Kasr El Ainy,who received“designed infection control educational program”for 6 months.The data were collected through the questionnaire comprising demographics,knowledge,and compliance with standard precautions questionnaire.The nurses’knowledge and compliance score were compared before and after intervention.Results:The studied nurses had higher level of knowledge(85.3%)and compliance(92.8%)regarding infection control standard precautions after the educational program compared to before the program.The results revealed statistically significant difference between before and after the program regarding nurses’knowledge score(15.5±2.9 vs.17.1±1.6,P<0.001)and compliance score(58.5±13.2 vs.74.3±5.1,P<0.001).In addition,there was insignificant relation between nurses’knowledge and compliance with standard precautions both before(r=0.952,P=0.474)and after educational program(r=0.164,P=0.223).Conclusion:The nurses’level of knowledge and compliance regarding infection control standard precautions was significantly improved after the program.Therefore,it is recommended that periodical educational programs regarding the standard precautions of infection control are essential for nurses at maternity hospital.展开更多
In the era of rapid information development,with the popularity of computers,the advancement of science and technology,and the ongoing expansion of IT technology and business,the enterprise resource planning(ERP)syste...In the era of rapid information development,with the popularity of computers,the advancement of science and technology,and the ongoing expansion of IT technology and business,the enterprise resource planning(ERP)system has evolved into a platform and a guarantee for the fulfilment of company management procedures after long-term operations.Because of developments in information technology,most manual accounting procedures are being replaced by computerized Accounting Information Systems(AIS),which are quicker and more accurate.The primary factors influencing the decisions of logistics firm trading parties are investigated in order to enhance the design of decision-supporting modules and to improve the performance of logistics enterprises through AIS.This paper proposed a novel approach to calculate the weights of each information element in order to establish their important degree.The main purpose of this research is to present a quantitative analytic approach for determining the important information of logistics business collaboration response.Furthermore,the idea of total orders and the significant degrees stated above are used to identify the optimal order of all information elements.Using the three ways of marginal revenue,marginal cost,and business matching degree,the information with cumulative weights is which is deployed to form the data from the intersection of the best order.It has the ability to drastically reduce the time and effort required to create a logistics business control/decision-making system.展开更多
Based on the comprehensive analysis of core, thin section, logging and seismic data, this study carried out the identification and comparison of Permian Changxing Formation sequences, clarified the typical sedimentary...Based on the comprehensive analysis of core, thin section, logging and seismic data, this study carried out the identification and comparison of Permian Changxing Formation sequences, clarified the typical sedimentary architectures of intra-platform shoal, investigated the vertical and horizontal development and distribution of intra-platform shoal in each sequence, and thus established the sedimentary evolution model of shoal body. The study results are reflected in four aspects.First, there are two complete third-order sequences(SQ1 and SQ2) in Changxing Formation in central Sichuan Basin. SQ1 is generally thick in the north and thin in the south, and SQ2 shows a thickness differentiation trend of “two thicknesses and three thinnesses”. Second, the Changxing Formation in central Sichuan Basin mainly develops intra-platform shoal, inter-shoal sea and intra-platform depression subfacies. In the vertical direction, the intra-platform shoal mainly presents two typical sedimentary sequences: stable superposed and high-frequency interbedded. Third, the stable superimposed sedimentary sequence is developed in the shoal belt at the edge of intra-platform depression, which is composed of two shoal-forming periods and located in the highstand systems tracts(HSTs) of SQ1 and SQ2. The high-frequency interbedded sedimentary sequence is developed in the southern shoal belt of intra-platform depression, which is composed of four shoal-forming periods and mainly located in the HST of SQ2. Fourth, during the SQ1 deposition, the intra-platform shoal was mainly developed at the edge of the intra-platform depression on the north side of the study area, and the inter-shoal sea subfacies was mainly developed on the south side. During the SQ2 deposition, the intra-platform shoal was widely developed in the area, forming two nearly parallel intra-platform shoal belts. The study results provide direction and ideas for exploration of Changxing Formation intra-platform shoal reservoirs in central Sichuan Basin.展开更多
Cybersecurity is therefore one of the most important elements of security in developed countries. Especially since there is an overall trend towards cybersecurity in all aspects of life, I have found that the idea of ...Cybersecurity is therefore one of the most important elements of security in developed countries. Especially since there is an overall trend towards cybersecurity in all aspects of life, I have found that the idea of cybersecurity is based on protecting critical facilities: The nation’s information infrastructure. Information systems, including e-government management systems, are managed by key state agencies. As with economic, scientific, commercial, and other systems, threats are threats to a nation’s national security. We have therefore found that many countries are preparing institutions capable of integrating cybersecurity into protection, development, and information security. This concept has become the most important concern of developed countries, which have secured all scientific possibilities and systems to achieve it. The electronic information network has become an integral part of today’s daily lives in all places. In addition to personal uses, digital information is used, processed, stored, and shared. As this information increases and spreads, we have found that its protection has become more vital and has an effective impact on national security and technical progress.展开更多
The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the e...The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.展开更多
BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We ...BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We retrospectively enrolled 32 pediatric patients with ALF admitted in five hospitals in different areas of China from January 2007 to December 2012. The coagulation indices, serum creatinine, serum lactate dehydrogenase,blood ammonia and prothrombin activity were analyzed; the relationship between these indices and mortality was evaluated by multivariate analysis.RESULTS: The most common causes of Chinese children with ALF were indeterminate etiology(15/32), drug toxicity(8/32),and acute cytomegalovirus hepatitis(6/32). Only 1 patient(3.13%)received liver transplantation and the spontaneous mortality of Chinese children with ALF was 58.06%(18/31). Patients who eventually died had higher baseline levels of international normalized ratio(P=0.01), serum creatinine(P=0.04), serum lactate dehydrogenase(P=0.01), blood ammonia(P<0.01) and lower prothrombin activity(P=0.01) than those who survived.Multivariate analysis showed that the entry blood ammonia was the only independent factor significantly associated with mortality(odds ratio=1.069, 95% confidence interval 1.023-1.117,P<0.01) and it had a sensitivity of 94.74%, a specificity of 84.62%and an accuracy of 90.63% for predicting the death. Based on the established model, with an increase of blood ammonia level,the risk of mortality would increase by 6.9%.CONCLUSIONS: The indeterminate causes predominated in the etiologies of ALF in Chinese children. The spontaneous mortality of pediatric patients with ALF was high, whereas the proportion of patients undergoing liver transplantation was significantly low. Entry blood ammonia was a reliable predictor for the death of pediatric patients with ALF.展开更多
Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management syste...Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management system,the authors measured the existing environmental quality at five MSW TSs.Discharged wastewater,air,and noise were monitored and assayed at the five TSs in Beijing in 2001-2006 during rainy seasons(RSs)and dry seasons(DSs).Except Ammonia(NH_3)and hydrogen sulfide(H_2S),the analytical results of...展开更多
Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related litera...Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related literature,this study aims to clarify the concept of physical restraint in mental health nursing.Method: Three databases (PubMed,PsyclNFO and CINAHL) were retrieved,and Walker and Avant's concept analysis method was used to analyze the concept of physical restraint in mental health nursing.Results: Physical restraint is a coercive approach that enables the administration of necessary treatment by safely reducing the patient's physical movement.It should be the last option used by qualified personnel.Antecedents of physical restraint are improper behavior (violence and disturbance) of patients,medical assessment prior to implementation and legislation governing clinical usage.Consequences of physical restraint are alleviation of conflict,physical injury,mental trauma and invisible impact on the institution.Discussion: This study defined the characteristics of physical restraint in mental health nursing.The proposed concept analysis provided theoretical foundation for future studies.展开更多
目的探讨营养补充是否能够提高运动干预对老年肌减少症患者的干预效果。方法系统检索英文数据库,包括Pubmed、Embase、Cochrane Library、Web of Science、CINAHL,以及中文数据库:中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普...目的探讨营养补充是否能够提高运动干预对老年肌减少症患者的干预效果。方法系统检索英文数据库,包括Pubmed、Embase、Cochrane Library、Web of Science、CINAHL,以及中文数据库:中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学数据库(CBM),建库至2016年7月19日的相关文章。采用Cochrane Handbook 5.10中的偏倚风险评估工具评价文章质量,使用Stata12.0软件进行Meta分析,对于不能合并的数据采用描述性分析。结果最终纳入6篇文章,共429例老年肌减少症患者。纳入的文章总体方法学质量等级为中等。与单纯运动干预相比,联合营养补充可进一步增加老年肌减少症患者的瘦体组织含量(5.78,95%CI:5.17~6.40,P=0.000)和肌肉含量(2.048,95%CI:0.907~3.189,P<0.001),同时增强患者的膝关节伸展度(1.08,95%CI:0.71~1.45,P<0.001)和正常步速(0.570,95%CI:0.19~0.95,P=0.003)。结论营养补充在一定程度上可提高运动干预在老年肌减少症患者肌肉组成、力量和身体活动能力方面的干预效果。但各研究间存在临床异质性,仍需开展更多严谨的大规模随机对照实验来验证营养联合运动干预的积极作用。展开更多
AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to infl...AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.展开更多
Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects (3600 cases and 3600 controls) were randomly sampled fro...Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects (3600 cases and 3600 controls) were randomly sampled from a cross-sectional study, and they were investigated for individual and occupational factors of low back pain. The potential risk factors were first selected by using chi-square tests. Secondly, collinearity diagnosis proceeded by using the Kendall's rank correlation. Finally, binary logistic regression model was used for multi-factor analysis. Results Collinearity diagnosis showed that there was a severe collinearity problem among the potential risk factors of low back pain. Logistic regression model included 20 variables with statistical significance. Bending neck forward or holding neck in a forward posturefor long periods (0R=1.408) was the most important risk factor inducing low back pain in this study, followed by bending heavily with the trunk (0R=1.402), carrying out identical work almost for the whole day (0R=1.340). Additionally, suHicient normal break was a protective factor of low back pain. Conclusion Low back pain among the Chinese occupational population was associated with body height, occupation, work organization, physical work, working posture, and others. All these risk factors could be regarded as the indicators of low back pain, and some relevant preventive measures should be taken to reduce low back pain risk.展开更多
Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important f...Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important for sustainable land use strategy. Two sub-catchments: catchment A (CA) and catchment B (CB) with distinct land uses were selected to measure soil moisture, runoff and soil nutrient loss in Da Nangou catchment of the Loess Plateau of China. The effects of land use patterns on runoff and nutrient losses were analyzed based on soil moisture pattern by kriging and soil nutrients using multiple regression model. The results indicated that there were significant differences in runoff yield and soil nutrient losses between the two sub-catchments. With similar land uses, the CA produced an average sediment yield of 49 kg ha^-1 and 22.27 kg ha^-1 during two storm events. Meanwhile, there was almost no runoff in the CB with dissimilar land uses during the same events. Buffer zones should be established to re-absorb runoff and to trap sediments in catchment with similar land use structure such as the CA. Moreover, land use management strategy aiming to increase the infiltration threshold of hydrological response units could decrease the frequency of runoff occurrence on a slope and catchment scale.展开更多
Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oi...Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oil and gas in fine-grained rocks.However,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale laminae.To close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale laminae.The laminae recognition models were built using well logs.The fine-grained rocks can be divided into laminated rocks(lamina thickness of<0.01 m),layered rocks(0.01-0.1 m),and massive rocks(no layer or layer spacing of>0.1 m)according to the laminae scale from core observations.According to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple structures.The typical mineral components,slabs,and T2spectrum distributions of various lamina types are unraveled.The core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale laminae.Furthermore,they can detect mineral types and their superposition sequence.Conventional logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter scales.Therefore,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical assemblage.The identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin sections.The layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated rocks.The laminated rocks’binary lamina is better than the ternary and multiple layers due to the high content of felsic minerals.The abovementioned results build the prediction model for multiscale laminae structure using well logs,helping sweet spots prediction in the Permian Lucaogou Formation in the Jimusar Sag and fine-grained sedimentary rocks worldwide.展开更多
Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with ...Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with 15 patients with IBD who were purposefully recruited from the gastroenterology department of two hospitals in Jiangsu,China to gain diversity in the demographic and clinical characteristics.The data were analyzed using a directed content analysis approach based on the Kumpfer's resilience framework.Results:The resilience framework for patients with IBD was formed from the analysis.This framework was composed of four themes,as follows:(1)complicated factors in the environment,(2)change the environment into a protective one,(3)personality traits,and(4)resilience-related coping.Conclusions:The resilience framework for patients with IBD can effectively characterize the resilience experience of patients during the disease and assist healthcare professionals to understand how patients recover from the disease.More quantitative studies are needed to further explore the influencing factors of resilience and improve resilience in patient with inflammatory Bowel Disease.展开更多
Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure ...Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure were recruited in this study from April 2014 to April 2015 from a hospital.Twenty-nine patients were in the intervention group,and 33 patients were in the control group.Patients in the intervention group received four sessions of motivational interviewing,whereas those in the control group received traditional health education.At 2,4,and 8 weeks post-discharge,the intervention group underwent telephone follow-up based on motivational interviewing,whereas the control group underwent routine telephone follow-up.Primary outcome was measured using the Self-care of Heart Failure Index at baseline and at 2 months postdischarge.Results:Before intervention,the self-care behaviours scores were 79.00±48.80 in the intervention group and 88.68±29.26in the control group.No statistically significant differences were found between two groups in scores for each subscale and total scale(P>0.05).After intervention,the scores of self-care behaviours in the two groups were both improved at 155.13±35.65 for the intervention group and 115.44±22.82 for the control group with statistically significance(P<0.01).The score of self-care behaviours increased by 76.13 point in the intervention group on average,whereas 26.76 point in the control group.There was significant difference between increases in scores of self-care behaviours in two groups(P<0.01).Conclusions:The self-care behaviours of patients with chronic heart failure could be improved effectively through motivational interviewing.展开更多
Objective: This study aims to use reflective theory and critical emancipatory theory to explore nurses' communicative role with unsatisfied clients.Methods: This paper begins with the broad issue, and the analysis...Objective: This study aims to use reflective theory and critical emancipatory theory to explore nurses' communicative role with unsatisfied clients.Methods: This paper begins with the broad issue, and the analysis will engage Smyth's cycle, which includes describing, analyzing,exploring, and reconstructing.Results: Critical emancipatory reflection is essential to make changes in the professional practice of nursing, because it is of primary importance for the professional learning and development of a nurse.Conclusions: Critical emancipatory reflection helps a nurse to analyze the constraints, including historical, sociocultural, political, and personal aspects.展开更多
Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Sha...Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Shan23 sub-member of Permian Shanxi Formation in the east margin of Ordos Basin was systematically analyzed in this study.The Shan23 sub-member has six lithofacies,namely,low TOC clay shale(C-L),low TOC siliceous shale(S-L),medium TOC siliceous shale(S-M),medium TOC hybrid shale(M-M),high TOC siliceous shale(S-H),and high TOC clay shale(C-H).Among them,S-H is the best lithofacies,S-M and M-M are the second best.The C-L and C-H lithofacies,mainly found in the upper part of Shan23 sub-member,generally developed in tide-dominated delta facies;the S-L,S-M,S-H and M-M shales occurring in the lower part of Shan23 sub-member developed in tide-dominated estuarine bay facies.The S-H,S-M and M-M shales have good pore struc-ture and largely organic matter pores and mineral interparticle pores,including interlayer pore in clay minerals,pyrite inter-crystalline pore,and mineral dissolution pore.C-L and S-L shales have mainly mineral interparticle pores and clay mineral in-terlayer pores,and a small amount of organic matter pores,showing poorer pore structure.The C-H shale has organic mi-cro-pores and a small number of interlayer fissures of clay minerals,showing good micro-pore structure,and poor meso-pore and macro-pore structure.The formation of favorable lithofacies is jointly controlled by depositional environment and diagen-esis.Shallow bay-lagoon depositional environment is conducive to the formation of type II2 kerogen which can produce a large number of organic cellular pores.Besides,the rich biogenic silica is conducive to the preservation of primary pores and en-hances the fracability of the shale reservoir.展开更多
基金supported by the Initial Scientific Research Fund of the Talents Introduced in Nanjing Lishui People’s Hospital(Project 2021YJ02).
文摘Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and inflammation.This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an ASM inhibitor,on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway.Methods:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD model.The cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-αgroup.Intracellular lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified ASM,NLRP3,and caspase 1 protein expression.Enzyme linked immunosorbent assay(ELISA)was measured CE and ASM levels,while qRT-PCR assessed mRNA expression.The apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in ASM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these indicators.Ami demonstrated a reduction in lipid deposition,suppressed ASM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved apoptosis.Additionally,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell model.Conclusion:The ASM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell damage.Ami emerges as a promising therapeutic agent by inhibiting the ASM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.
文摘Nuclear medicine plays an irreplaceable role in the diagnosis and treatment of tumors.Radiopharmaceuticals are important components of nuclear medicine.Among the radiopharmaceuticals approved by the Food and Drug Administration(FDA),radio-tracers targeting prostate-specific membrane antigen(PSMA)and somatostatin receptor(SSTR)have held essential positions in the diagnosis and treatment of prostate cancers and neuroendocrine neoplasms,respectively.In recent years,FDA-approved serials of immune-therapy and targeted therapy drugs targeting programmed death 1(PD-1)/programmed death ligand 1(PD-L1),human epidermal growth factor receptor 2(HER2),and nectin cell adhesion molecule 4(Nectin 4).How to screen patients suitable for these treatments and monitor the therapy?Nuclear medicine with specific radiopharmaceuticals can visualize the expression level of those targets in systemic lesions and evaluate the efficacy of treatment.In addition to radiopharmaceuticals,imaging equipment is also a key step for nuclear medicine.Advanced equipment including total-body positron emission tomography/computed tomography(PET/CT)and positron emission tomography/magnetic resonance imaging(PET/MRI)has been developed,which contribute to the diagnosis and treatment of tumors,as well as the development of new radiopharmaceuticals.Here,we conclude most recently advances of radiopharmaceuticals in nuclear medicine,and they substantially increase the“arsenal”of clinicians for tumor therapy.
文摘Objectives:This study aimed to assess the nurses’knowledge and compliance with infection control standard precautions and evaluate the impact of the designed infection control educational program on nurses’knowledge and compliance with standard precautions at the maternity hospital.Materials and Methods:A quasi‑experimental one‑group pretest‑posttest design was used on convenient sample of 60 nurses working at Obstetrics and Gynecological hospital in Cairo University Hospital,Kasr El Ainy,who received“designed infection control educational program”for 6 months.The data were collected through the questionnaire comprising demographics,knowledge,and compliance with standard precautions questionnaire.The nurses’knowledge and compliance score were compared before and after intervention.Results:The studied nurses had higher level of knowledge(85.3%)and compliance(92.8%)regarding infection control standard precautions after the educational program compared to before the program.The results revealed statistically significant difference between before and after the program regarding nurses’knowledge score(15.5±2.9 vs.17.1±1.6,P<0.001)and compliance score(58.5±13.2 vs.74.3±5.1,P<0.001).In addition,there was insignificant relation between nurses’knowledge and compliance with standard precautions both before(r=0.952,P=0.474)and after educational program(r=0.164,P=0.223).Conclusion:The nurses’level of knowledge and compliance regarding infection control standard precautions was significantly improved after the program.Therefore,it is recommended that periodical educational programs regarding the standard precautions of infection control are essential for nurses at maternity hospital.
基金This work was supported by the Researchers Supporting Project(No.RSP-2021/395),King Saud University,Riyadh,Saudi Arabia.
文摘In the era of rapid information development,with the popularity of computers,the advancement of science and technology,and the ongoing expansion of IT technology and business,the enterprise resource planning(ERP)system has evolved into a platform and a guarantee for the fulfilment of company management procedures after long-term operations.Because of developments in information technology,most manual accounting procedures are being replaced by computerized Accounting Information Systems(AIS),which are quicker and more accurate.The primary factors influencing the decisions of logistics firm trading parties are investigated in order to enhance the design of decision-supporting modules and to improve the performance of logistics enterprises through AIS.This paper proposed a novel approach to calculate the weights of each information element in order to establish their important degree.The main purpose of this research is to present a quantitative analytic approach for determining the important information of logistics business collaboration response.Furthermore,the idea of total orders and the significant degrees stated above are used to identify the optimal order of all information elements.Using the three ways of marginal revenue,marginal cost,and business matching degree,the information with cumulative weights is which is deployed to form the data from the intersection of the best order.It has the ability to drastically reduce the time and effort required to create a logistics business control/decision-making system.
基金Supported by the PetroChina-Southwest Petroleum University Innovation Consortium Technology Cooperation Project (2020CX010000)。
文摘Based on the comprehensive analysis of core, thin section, logging and seismic data, this study carried out the identification and comparison of Permian Changxing Formation sequences, clarified the typical sedimentary architectures of intra-platform shoal, investigated the vertical and horizontal development and distribution of intra-platform shoal in each sequence, and thus established the sedimentary evolution model of shoal body. The study results are reflected in four aspects.First, there are two complete third-order sequences(SQ1 and SQ2) in Changxing Formation in central Sichuan Basin. SQ1 is generally thick in the north and thin in the south, and SQ2 shows a thickness differentiation trend of “two thicknesses and three thinnesses”. Second, the Changxing Formation in central Sichuan Basin mainly develops intra-platform shoal, inter-shoal sea and intra-platform depression subfacies. In the vertical direction, the intra-platform shoal mainly presents two typical sedimentary sequences: stable superposed and high-frequency interbedded. Third, the stable superimposed sedimentary sequence is developed in the shoal belt at the edge of intra-platform depression, which is composed of two shoal-forming periods and located in the highstand systems tracts(HSTs) of SQ1 and SQ2. The high-frequency interbedded sedimentary sequence is developed in the southern shoal belt of intra-platform depression, which is composed of four shoal-forming periods and mainly located in the HST of SQ2. Fourth, during the SQ1 deposition, the intra-platform shoal was mainly developed at the edge of the intra-platform depression on the north side of the study area, and the inter-shoal sea subfacies was mainly developed on the south side. During the SQ2 deposition, the intra-platform shoal was widely developed in the area, forming two nearly parallel intra-platform shoal belts. The study results provide direction and ideas for exploration of Changxing Formation intra-platform shoal reservoirs in central Sichuan Basin.
文摘Cybersecurity is therefore one of the most important elements of security in developed countries. Especially since there is an overall trend towards cybersecurity in all aspects of life, I have found that the idea of cybersecurity is based on protecting critical facilities: The nation’s information infrastructure. Information systems, including e-government management systems, are managed by key state agencies. As with economic, scientific, commercial, and other systems, threats are threats to a nation’s national security. We have therefore found that many countries are preparing institutions capable of integrating cybersecurity into protection, development, and information security. This concept has become the most important concern of developed countries, which have secured all scientific possibilities and systems to achieve it. The electronic information network has become an integral part of today’s daily lives in all places. In addition to personal uses, digital information is used, processed, stored, and shared. As this information increases and spreads, we have found that its protection has become more vital and has an effective impact on national security and technical progress.
基金Supported by the National Natural Science Foundation of China (20866001) the Natural Science Foundation of GuangxiProvince (0832035)
文摘The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.
文摘BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We retrospectively enrolled 32 pediatric patients with ALF admitted in five hospitals in different areas of China from January 2007 to December 2012. The coagulation indices, serum creatinine, serum lactate dehydrogenase,blood ammonia and prothrombin activity were analyzed; the relationship between these indices and mortality was evaluated by multivariate analysis.RESULTS: The most common causes of Chinese children with ALF were indeterminate etiology(15/32), drug toxicity(8/32),and acute cytomegalovirus hepatitis(6/32). Only 1 patient(3.13%)received liver transplantation and the spontaneous mortality of Chinese children with ALF was 58.06%(18/31). Patients who eventually died had higher baseline levels of international normalized ratio(P=0.01), serum creatinine(P=0.04), serum lactate dehydrogenase(P=0.01), blood ammonia(P<0.01) and lower prothrombin activity(P=0.01) than those who survived.Multivariate analysis showed that the entry blood ammonia was the only independent factor significantly associated with mortality(odds ratio=1.069, 95% confidence interval 1.023-1.117,P<0.01) and it had a sensitivity of 94.74%, a specificity of 84.62%and an accuracy of 90.63% for predicting the death. Based on the established model, with an increase of blood ammonia level,the risk of mortality would increase by 6.9%.CONCLUSIONS: The indeterminate causes predominated in the etiologies of ALF in Chinese children. The spontaneous mortality of pediatric patients with ALF was high, whereas the proportion of patients undergoing liver transplantation was significantly low. Entry blood ammonia was a reliable predictor for the death of pediatric patients with ALF.
文摘Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management system,the authors measured the existing environmental quality at five MSW TSs.Discharged wastewater,air,and noise were monitored and assayed at the five TSs in Beijing in 2001-2006 during rainy seasons(RSs)and dry seasons(DSs).Except Ammonia(NH_3)and hydrogen sulfide(H_2S),the analytical results of...
基金We acknowledge this paper was supported by the program of Key Specialty of TCM Nursing of Guangzhou City,which aims to enrich theoretical content of mental health nursing
文摘Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related literature,this study aims to clarify the concept of physical restraint in mental health nursing.Method: Three databases (PubMed,PsyclNFO and CINAHL) were retrieved,and Walker and Avant's concept analysis method was used to analyze the concept of physical restraint in mental health nursing.Results: Physical restraint is a coercive approach that enables the administration of necessary treatment by safely reducing the patient's physical movement.It should be the last option used by qualified personnel.Antecedents of physical restraint are improper behavior (violence and disturbance) of patients,medical assessment prior to implementation and legislation governing clinical usage.Consequences of physical restraint are alleviation of conflict,physical injury,mental trauma and invisible impact on the institution.Discussion: This study defined the characteristics of physical restraint in mental health nursing.The proposed concept analysis provided theoretical foundation for future studies.
基金a Grant-in-Aid for Young Scientists from the Ministry of Education,Culture,Sports,Science and Technology of Japana Grant-in-Aid for Scientific Research from the Ministry of Health,Labour and Welfare of Japan
文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.
基金supported by the Research Fund from National Science and Technology Infrastructure Program of the People's Republic of China, 2006BA106B08
文摘Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects (3600 cases and 3600 controls) were randomly sampled from a cross-sectional study, and they were investigated for individual and occupational factors of low back pain. The potential risk factors were first selected by using chi-square tests. Secondly, collinearity diagnosis proceeded by using the Kendall's rank correlation. Finally, binary logistic regression model was used for multi-factor analysis. Results Collinearity diagnosis showed that there was a severe collinearity problem among the potential risk factors of low back pain. Logistic regression model included 20 variables with statistical significance. Bending neck forward or holding neck in a forward posturefor long periods (0R=1.408) was the most important risk factor inducing low back pain in this study, followed by bending heavily with the trunk (0R=1.402), carrying out identical work almost for the whole day (0R=1.340). Additionally, suHicient normal break was a protective factor of low back pain. Conclusion Low back pain among the Chinese occupational population was associated with body height, occupation, work organization, physical work, working posture, and others. All these risk factors could be regarded as the indicators of low back pain, and some relevant preventive measures should be taken to reduce low back pain risk.
基金National Natural Science Foundation of China, No.40401001 No.40201003 Programme of Excellent YoungScientistsoftheM inistry ofLand and Resources
文摘Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important for sustainable land use strategy. Two sub-catchments: catchment A (CA) and catchment B (CB) with distinct land uses were selected to measure soil moisture, runoff and soil nutrient loss in Da Nangou catchment of the Loess Plateau of China. The effects of land use patterns on runoff and nutrient losses were analyzed based on soil moisture pattern by kriging and soil nutrients using multiple regression model. The results indicated that there were significant differences in runoff yield and soil nutrient losses between the two sub-catchments. With similar land uses, the CA produced an average sediment yield of 49 kg ha^-1 and 22.27 kg ha^-1 during two storm events. Meanwhile, there was almost no runoff in the CB with dissimilar land uses during the same events. Buffer zones should be established to re-absorb runoff and to trap sediments in catchment with similar land use structure such as the CA. Moreover, land use management strategy aiming to increase the infiltration threshold of hydrological response units could decrease the frequency of runoff occurrence on a slope and catchment scale.
基金National Natural Science Foundation of China(Grant No.42002133,42072150)Science Foundation of China University of Petroleum,Beijing(No.2462021YXZZ003)the Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX2020-01-06)for the financial supports and permissions to publish this paper
文摘Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oil and gas in fine-grained rocks.However,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale laminae.To close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale laminae.The laminae recognition models were built using well logs.The fine-grained rocks can be divided into laminated rocks(lamina thickness of<0.01 m),layered rocks(0.01-0.1 m),and massive rocks(no layer or layer spacing of>0.1 m)according to the laminae scale from core observations.According to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple structures.The typical mineral components,slabs,and T2spectrum distributions of various lamina types are unraveled.The core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale laminae.Furthermore,they can detect mineral types and their superposition sequence.Conventional logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter scales.Therefore,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical assemblage.The identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin sections.The layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated rocks.The laminated rocks’binary lamina is better than the ternary and multiple layers due to the high content of felsic minerals.The abovementioned results build the prediction model for multiscale laminae structure using well logs,helping sweet spots prediction in the Permian Lucaogou Formation in the Jimusar Sag and fine-grained sedimentary rocks worldwide.
基金This work was supported by the Special Project of Philosophy and Social Science Development of Nanjing Medical University (grant no.2017ZSZ007)
文摘Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with 15 patients with IBD who were purposefully recruited from the gastroenterology department of two hospitals in Jiangsu,China to gain diversity in the demographic and clinical characteristics.The data were analyzed using a directed content analysis approach based on the Kumpfer's resilience framework.Results:The resilience framework for patients with IBD was formed from the analysis.This framework was composed of four themes,as follows:(1)complicated factors in the environment,(2)change the environment into a protective one,(3)personality traits,and(4)resilience-related coping.Conclusions:The resilience framework for patients with IBD can effectively characterize the resilience experience of patients during the disease and assist healthcare professionals to understand how patients recover from the disease.More quantitative studies are needed to further explore the influencing factors of resilience and improve resilience in patient with inflammatory Bowel Disease.
文摘Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure were recruited in this study from April 2014 to April 2015 from a hospital.Twenty-nine patients were in the intervention group,and 33 patients were in the control group.Patients in the intervention group received four sessions of motivational interviewing,whereas those in the control group received traditional health education.At 2,4,and 8 weeks post-discharge,the intervention group underwent telephone follow-up based on motivational interviewing,whereas the control group underwent routine telephone follow-up.Primary outcome was measured using the Self-care of Heart Failure Index at baseline and at 2 months postdischarge.Results:Before intervention,the self-care behaviours scores were 79.00±48.80 in the intervention group and 88.68±29.26in the control group.No statistically significant differences were found between two groups in scores for each subscale and total scale(P>0.05).After intervention,the scores of self-care behaviours in the two groups were both improved at 155.13±35.65 for the intervention group and 115.44±22.82 for the control group with statistically significance(P<0.01).The score of self-care behaviours increased by 76.13 point in the intervention group on average,whereas 26.76 point in the control group.There was significant difference between increases in scores of self-care behaviours in two groups(P<0.01).Conclusions:The self-care behaviours of patients with chronic heart failure could be improved effectively through motivational interviewing.
文摘Objective: This study aims to use reflective theory and critical emancipatory theory to explore nurses' communicative role with unsatisfied clients.Methods: This paper begins with the broad issue, and the analysis will engage Smyth's cycle, which includes describing, analyzing,exploring, and reconstructing.Results: Critical emancipatory reflection is essential to make changes in the professional practice of nursing, because it is of primary importance for the professional learning and development of a nurse.Conclusions: Critical emancipatory reflection helps a nurse to analyze the constraints, including historical, sociocultural, political, and personal aspects.
基金China National Science and Technology Major Project(2017ZX05035).
文摘Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Shan23 sub-member of Permian Shanxi Formation in the east margin of Ordos Basin was systematically analyzed in this study.The Shan23 sub-member has six lithofacies,namely,low TOC clay shale(C-L),low TOC siliceous shale(S-L),medium TOC siliceous shale(S-M),medium TOC hybrid shale(M-M),high TOC siliceous shale(S-H),and high TOC clay shale(C-H).Among them,S-H is the best lithofacies,S-M and M-M are the second best.The C-L and C-H lithofacies,mainly found in the upper part of Shan23 sub-member,generally developed in tide-dominated delta facies;the S-L,S-M,S-H and M-M shales occurring in the lower part of Shan23 sub-member developed in tide-dominated estuarine bay facies.The S-H,S-M and M-M shales have good pore struc-ture and largely organic matter pores and mineral interparticle pores,including interlayer pore in clay minerals,pyrite inter-crystalline pore,and mineral dissolution pore.C-L and S-L shales have mainly mineral interparticle pores and clay mineral in-terlayer pores,and a small amount of organic matter pores,showing poorer pore structure.The C-H shale has organic mi-cro-pores and a small number of interlayer fissures of clay minerals,showing good micro-pore structure,and poor meso-pore and macro-pore structure.The formation of favorable lithofacies is jointly controlled by depositional environment and diagen-esis.Shallow bay-lagoon depositional environment is conducive to the formation of type II2 kerogen which can produce a large number of organic cellular pores.Besides,the rich biogenic silica is conducive to the preservation of primary pores and en-hances the fracability of the shale reservoir.