Oligo(p-phenyleneethynylene)s(OPEs)end-capped with(alkynyl)bis(diphosphine)ruthenium and thiol/thiolate groups stabilize ca.2 nm diameter gold nanoparticles(AuNPs).The morphology,elemental composition and stability of...Oligo(p-phenyleneethynylene)s(OPEs)end-capped with(alkynyl)bis(diphosphine)ruthenium and thiol/thiolate groups stabilize ca.2 nm diameter gold nanoparticles(AuNPs).The morphology,elemental composition and stability of the resultant organometallic OPE/AuNP hybrid materials have been defined using a combination of molecular-and nano-material chacterization techniques.The hybrids display long-term stability in solution(more than a month),good solubility in organic solvents,reversible rutheniumcentered oxidation,and transparency beyond 800 nm,and possess very strong nonlinear absorption activity at the first biological window,and unprecedented two-photon absorption activity in the second biological window(σ2 up to 38,000 GM at 1,050 nm).展开更多
Bacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering,death and increased costs of healthcare.To address this problem,we propose using flexible organic light-...Bacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering,death and increased costs of healthcare.To address this problem,we propose using flexible organic light-emitting diodes(OLEDs)as light sources for photodynamic therapy(PDT)to kill bacteria.PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells.We have developed flexible top-emitting OLEDs with the ability to tune the emission peak from 669 to 737 nm to match the photosensitizer,together with high irradiance,low driving voltage,long operational lifetime and adequate shelf-life.These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources.A detailed study of OLED–PDT for killing Staphylococcus aureus was performed.The results show that our OLEDs in combination with the photosensitizer methylene blue,can kill more than 99%of bacteria.This indicates a huge potential for using OLEDs to treat bacterial infections.展开更多
基金We thank the Australian Research Council(DP170100411:M.G.H.and M.S.)the National Science Centre(NCN)Poland(UMO-2016/22/M/ST4/00275:J.K.Z.and M.S.)for support of this work.C.Q.thanks Becas Chile(Agencia Nacional de Investigacion y Desarrollo)for financial support in the form of a PhD scholarship(2015-72160061),J.P.L.M.thanks the Australian Government for an Australian Postgraduate Award,J.D.thanks the China Scholarship Council and the Australian National University for a CSC-ANU scholarship,and J.K.Z.thanks the Foundation for Polish Science(FNP)for support.The authors acknowledge the facilities,and the scientific and technical assistance,of the Australian Microscopy&Microanalysis Research Facility and the Centre of Advanced Microscopy at the Australian National University.
文摘Oligo(p-phenyleneethynylene)s(OPEs)end-capped with(alkynyl)bis(diphosphine)ruthenium and thiol/thiolate groups stabilize ca.2 nm diameter gold nanoparticles(AuNPs).The morphology,elemental composition and stability of the resultant organometallic OPE/AuNP hybrid materials have been defined using a combination of molecular-and nano-material chacterization techniques.The hybrids display long-term stability in solution(more than a month),good solubility in organic solvents,reversible rutheniumcentered oxidation,and transparency beyond 800 nm,and possess very strong nonlinear absorption activity at the first biological window,and unprecedented two-photon absorption activity in the second biological window(σ2 up to 38,000 GM at 1,050 nm).
文摘Bacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering,death and increased costs of healthcare.To address this problem,we propose using flexible organic light-emitting diodes(OLEDs)as light sources for photodynamic therapy(PDT)to kill bacteria.PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells.We have developed flexible top-emitting OLEDs with the ability to tune the emission peak from 669 to 737 nm to match the photosensitizer,together with high irradiance,low driving voltage,long operational lifetime and adequate shelf-life.These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources.A detailed study of OLED–PDT for killing Staphylococcus aureus was performed.The results show that our OLEDs in combination with the photosensitizer methylene blue,can kill more than 99%of bacteria.This indicates a huge potential for using OLEDs to treat bacterial infections.
