Many approaches have been proposed to pre-compute data cubes in order to efficiently respond to OLAP queries in data warehouses. However, few have proposed solutions integrating all of the possible outcomes, and it is...Many approaches have been proposed to pre-compute data cubes in order to efficiently respond to OLAP queries in data warehouses. However, few have proposed solutions integrating all of the possible outcomes, and it is this idea that leads the integration of hierarchical dimensions into these responses. To meet this need, we propose, in this paper, a complete redefinition of the framework and the formal definition of traditional database analysis through the prism of hierarchical dimensions. After characterizing the hierarchical data cube lattice, we introduce the hierarchical data cube and its most concise reduced representation, the closed hierarchical data cube. It offers compact replication so as to optimize storage space by removing redundancies of strongly correlated data. Such data are typical of data warehouses, and in particular in video games, our field of study and experimentation, where hierarchical dimension attributes are widely represented.展开更多
This investigation deals with the effects of slip,magnetic field,and nonNewtonian flow parameters on the flow and heat transfer of an incompressible,electrically conducting fourth-grade fluid past an infinite porous p...This investigation deals with the effects of slip,magnetic field,and nonNewtonian flow parameters on the flow and heat transfer of an incompressible,electrically conducting fourth-grade fluid past an infinite porous plate.The heat transfer analysis is carried out for two heating processes.The system of highly non-linear differential equations is solved by the shooting method with the fourth-order Runge-Kutta method for moderate values of the parameters.The effective Broyden technique is adopted in order to improve the initial guesses and to satisfy the boundary conditions at infinity.An exceptional cross-over is obtained in the velocity profile in the presence of slip.The fourth-grade fluid parameter is found to increase the momentum boundary layer thickness,whereas the slip parameter substantially decreases it.Similarly,the non-Newtonian fluid parameters and the slip have opposite effects on the thermal boundary layer thickness.展开更多
The process of ultrafiltration(UF)of natural seawater often encounters the problems of variation in water quality and coastal blooms.To validate the feasibility of UF in shellfish farms,this study compared the hydraul...The process of ultrafiltration(UF)of natural seawater often encounters the problems of variation in water quality and coastal blooms.To validate the feasibility of UF in shellfish farms,this study compared the hydraulic performance and pollutant removal efficiency of the UF process with those of the commonly used treatments that combine several filtration steps with ultraviolet(UV)disinfection.The comparison was conducted in the cases of natural seawater and a coastal bloom.Given that the UF process encountered the specific type of pollution,this study evaluated the filtration performance of the UF process and the retention of total suspended solids(TSS),bacteria,phytoplankton,and zooplankton.A real coastal bloom was considered in the case study of an experimental shellfish hatchery/nursery in France.The results show that both treatments were able to eliminate approximately 50%of TSS.However,in contrast with UV treatment combined with filtration,the UF process retained total amounts of phytoplankton,zooplankton,and bacteria in the bloom.Although the hydraulic performance of the UF process was impacted by the coastal bloom,the fouling was eliminated through chemical cleaning conducted at a frequency less than once per 12 h.Despite the severe pollution,this study confirmed the pollution resistance and treatment performance of the UF process,indicating that UF has the potential to enhance the biosecurity level.展开更多
Faecal incontinence(FI) is a disabling and frequent symptom since its prevalence can vary between 5% and 15% of the general population. It has a particular negative impact on quality of life. Many tools are currently ...Faecal incontinence(FI) is a disabling and frequent symptom since its prevalence can vary between 5% and 15% of the general population. It has a particular negative impact on quality of life. Many tools are currently available for the treatment of FI, from conservative measures to invasive surgical treatments. The conservative treatment may be dietetic measures, various pharmacological agents, anorectal rehabilitation, posterior tibial nerve stimulation, and transanal irrigation. If needed, patients may have miniinvasive approaches such as sacral nerve modulation or antegrade irrigation. In some cases, a surgical treatment is proposed, mainly external anal sphincter repair. Although these different therapeutic options are available, new techniques are arriving allowing new hopes for the patients. Moreover, most of them are non-invasive such as local application of an α1-adrenoceptor agonist, stem cell injections, rectal injection of botulinum toxin, acupuncture. New more invasive techniques with promising results are also coming such as anal magnetic sphincter and antropylorus transposition. This review reports the main current available treatments of FI and the developing therapeutics tools.展开更多
Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(T.cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC pat...Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(T.cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of T.cruzi infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.展开更多
Recent advances in stem cell technologies have opened new avenues for the treatment of a number of diseases still lacking effective therapeutic options.Cell transplantation has emerged as among the most promising clin...Recent advances in stem cell technologies have opened new avenues for the treatment of a number of diseases still lacking effective therapeutic options.Cell transplantation has emerged as among the most promising clinical intervention for disorders such as injuries,diabetes。展开更多
The electric field induced Lyman-α emission diagnostic aims to provide a non intrusive and precise measurement of the electric field in plasma, using a beam of hydrogen atoms prepared in the metastable 2 s state. The...The electric field induced Lyman-α emission diagnostic aims to provide a non intrusive and precise measurement of the electric field in plasma, using a beam of hydrogen atoms prepared in the metastable 2 s state. The metastable particles are obtained by means of a proton beam extracted from a hydrogen plasma source, and neutralised by interaction with vaporised caesium.When a 2 s atom enters a region where an electric field is present, it undergoes a transition to the2 p state(Stark mixing). It then quickly decays to the ground level, emitting Lyman-α radiation,which is collected by a photomultiplier. The 2 s→2 p transition rate is proportional to the square of the magnitude of the electric field, and depends on the field oscillation frequency(with peaks around 1 GHz). By measuring the intensity of the Lyman-α radiation emitted by the beam it is possible to determine the magnitude of the field in a defined region. In this work, an analysis of the behaviour of the diagnostic under static or radiofrequency electric field is presented. Electric field simulations obtained with a finite element solver of Maxwell equations, combined with theoretical calculations of the Stark mixing transition rate, are used to develop a model for the interpretation of photomultiplier data. This method shows good agreement with experimental results for the static field case, and allows to measure the field magnitude for the oscillating case.展开更多
The sophisticated structures of flapping insect wings make it challenging to study the role of wing flexibility in insect flight.In this study,a mass-spring system is used to model wing structural dynamics as a thin,f...The sophisticated structures of flapping insect wings make it challenging to study the role of wing flexibility in insect flight.In this study,a mass-spring system is used to model wing structural dynamics as a thin,flexible membrane supported by a network of veins.The vein mechanical properties can be estimated based on their diameters and the Young's modulus of cuticle.In order to analyze the effect of wing flexibility,the Young's modulus is varied to make a comparison between two different wing models that we refer to as flexible and highly flexible.The wing models are coupled with a pseudo-spectral code solving the incompressible Navier–Stokes equations,allowing us to investigate the influence of wing deformation on the aerodynamic efficiency of a tethered flapping bumblebee.Compared to the bumblebee model with rigid wings,the one with flexible wings flies more efficiently,characterized by a larger lift-to-power ratio.展开更多
We present a Stark–Zeeman spectral line-shape model and the associated numerical code,PPPB,designed to provide fast and accurate line shapes for arbitrary atomic systems for a large range of plasma conditions.PPPB is...We present a Stark–Zeeman spectral line-shape model and the associated numerical code,PPPB,designed to provide fast and accurate line shapes for arbitrary atomic systems for a large range of plasma conditions.PPPB is based on the coupling of the PPP code-a Stark-broadened spectral line-shape code developed for multi-electron ion spectroscopy in hot dense plasmas-and the MASCB code developed recently to generate B-field-dependent atomic physics.The latter provides energy levels,statistical weights,and reduced matrix elements of multi-electron radiators by diagonalizing the atomic Hamiltonian that includes the well know B-dependent term.These are then used as inputs to PPP working in the standard line-broadening approach,i.e.,using the quasi-static ion and impact electron approximations.The effects of ion dynamics are introduced by means of the frequency fluctuation model,and the physical model of electron broadening is based on the semi-classical impact approximation including the effects of a strong collision term,interference,and cyclotron motion.Finally,to account for polarization effects,the output profiles are calculated for a given angle of observation with respect to the direction of the magnetic field.The potential of this model is presented through Stark–Zeeman spectral line-shape calculations performed for various experimental conditions.展开更多
We discuss the possibility of realizing time-resolved Kossel diffraction experiments for providing indications on the crystalline order or the periodic structure of a material.We make use of the interaction of short,u...We discuss the possibility of realizing time-resolved Kossel diffraction experiments for providing indications on the crystalline order or the periodic structure of a material.We make use of the interaction of short,ultra-intense laser pulses with a solid target,which generates short bursts of hot electrons.Penetrating inside a layered sample(i.e.,a crystal or an artificial multilayer material),these electrons ionize inner-shell electrons so that the subsequent radiative filling of K-shell vacancies results in a strong Kαemission that is enhanced in the Bragg directions corresponding to the period of the material.We present simulations of angle-resolved Kαemission,which displays so-called Kossel patterns around the Bragg angles.We then discuss possible experiments appropriate for laser facilities delivering short and intense pulses.展开更多
In this study, the reproduction of the sand smelt, Atherina lagunae, from the Tunis North Lake is investigated. The smallest mature female was 39 mm total length (TL). Fifty percent of the females were mature at 58 mm...In this study, the reproduction of the sand smelt, Atherina lagunae, from the Tunis North Lake is investigated. The smallest mature female was 39 mm total length (TL). Fifty percent of the females were mature at 58 mm (TL). The yearly and monthly average gonadosomatic indexes (GSI) are presented. The average value of GSI for the 12-month period was respectively 3.02%, 2.57% and 2.8% for females, males and both sexes. The GSI began to increase in March (2.37% for females and 2.12% for males). The maximum GSI was recorded in May, 11.29% for females and 10.03% for males. The highest values were recorded between March and July, indicating the reproduction period of Atherina lagunae in the Tunis North Lake. Similar GSI values were recorded in sand smelt males from brackish lagoons of southern France.展开更多
AIM: To quantify the wrist cartilage cross-sectional area in humans from a 3D magnetic resonance imaging(MRI) dataset and to assess the corresponding reproducibility. METHODS: The study was conducted in 14 healthy vol...AIM: To quantify the wrist cartilage cross-sectional area in humans from a 3D magnetic resonance imaging(MRI) dataset and to assess the corresponding reproducibility. METHODS: The study was conducted in 14 healthy volunteers(6 females and 8 males) between 30 and 58 years old and devoid of articular pain. Subjectswere asked to lie down in the supine position with the right hand positioned above the pelvic region on top of a home-built rigid platform attached to the scanner bed. The wrist was wrapped with a flexible surface coil. MRI investigations were performed at 3T(Verio-Siemens) using volume interpolated breath hold examination(VIBE) and dual echo steady state(DESS) MRI sequences. Cartilage cross sectional area(CSA) was measured on a slice of interest selected from a 3D dataset of the entire carpus and metacarpalphalangeal areas on the basis of anatomical criteria using conventional image processing radiology software. Cartilage cross-sectional areas between opposite bones in the carpal region were manually selected and quantified using a thresholding method.RESULTS: Cartilage CSA measurements performed on a selected predefined slice were 292.4 ± 39 mm2 using the VIBE sequence and slightly lower, 270.4 ± 50.6 mm2, with the DESS sequence. The inter(14.1%) and intra(2.4%) subject variability was similar for both MRI methods. The coefficients of variation computed for the repeated measurements were also comparable for the VIBE(2.4%) and the DESS(4.8%) sequences. The carpus length averaged over the group was 37.5 ± 2.8 mm with a 7.45% between-subjects coefficient of variation. Of note, wrist cartilage CSA measured with either the VIBE or the DESS sequences was linearly related to the carpal bone length. The variability between subjects was significantly reduced to 8.4% when the CSA was normalized with respect to the carpal bone length.CONCLUSION: The ratio between wrist cartilage CSA and carpal bone length is a highly reproducible standardized measurement which normalizes the natural diversity between individuals.展开更多
We present numerical simulations of simplified models for swimming organisms or robots, using chordwise flexible elastic plates. We focus on the tip vortices originating from three-dimensional effects due to the finit...We present numerical simulations of simplified models for swimming organisms or robots, using chordwise flexible elastic plates. We focus on the tip vortices originating from three-dimensional effects due to the finite span of the plate. These effects play an important role when predicting the swimmer's cruising velocity, since they contribute significantly to the drag force. First we simulate swimmers with rectangular plates of different aspect ratios and compare the results with a recent experimental study. Then we consider plates with expanding and contracting shapes. We find the cruising velocity of the contracting swimmer to be higher than the rectangular one, which in turn is higher than the expanding one. We provide some evidence that this result is due to the tip vortices interacting differently with the swimmer.展开更多
文摘Many approaches have been proposed to pre-compute data cubes in order to efficiently respond to OLAP queries in data warehouses. However, few have proposed solutions integrating all of the possible outcomes, and it is this idea that leads the integration of hierarchical dimensions into these responses. To meet this need, we propose, in this paper, a complete redefinition of the framework and the formal definition of traditional database analysis through the prism of hierarchical dimensions. After characterizing the hierarchical data cube lattice, we introduce the hierarchical data cube and its most concise reduced representation, the closed hierarchical data cube. It offers compact replication so as to optimize storage space by removing redundancies of strongly correlated data. Such data are typical of data warehouses, and in particular in video games, our field of study and experimentation, where hierarchical dimension attributes are widely represented.
文摘This investigation deals with the effects of slip,magnetic field,and nonNewtonian flow parameters on the flow and heat transfer of an incompressible,electrically conducting fourth-grade fluid past an infinite porous plate.The heat transfer analysis is carried out for two heating processes.The system of highly non-linear differential equations is solved by the shooting method with the fourth-order Runge-Kutta method for moderate values of the parameters.The effective Broyden technique is adopted in order to improve the initial guesses and to satisfy the boundary conditions at infinity.An exceptional cross-over is obtained in the velocity profile in the presence of slip.The fourth-grade fluid parameter is found to increase the momentum boundary layer thickness,whereas the slip parameter substantially decreases it.Similarly,the non-Newtonian fluid parameters and the slip have opposite effects on the thermal boundary layer thickness.
基金This work was supported by Fonds Europeen Pour les Affaires Maritimes et la P^eche(FEAMP)(Grant No.R FEA 4700 16FA 1000001).
文摘The process of ultrafiltration(UF)of natural seawater often encounters the problems of variation in water quality and coastal blooms.To validate the feasibility of UF in shellfish farms,this study compared the hydraulic performance and pollutant removal efficiency of the UF process with those of the commonly used treatments that combine several filtration steps with ultraviolet(UV)disinfection.The comparison was conducted in the cases of natural seawater and a coastal bloom.Given that the UF process encountered the specific type of pollution,this study evaluated the filtration performance of the UF process and the retention of total suspended solids(TSS),bacteria,phytoplankton,and zooplankton.A real coastal bloom was considered in the case study of an experimental shellfish hatchery/nursery in France.The results show that both treatments were able to eliminate approximately 50%of TSS.However,in contrast with UV treatment combined with filtration,the UF process retained total amounts of phytoplankton,zooplankton,and bacteria in the bloom.Although the hydraulic performance of the UF process was impacted by the coastal bloom,the fouling was eliminated through chemical cleaning conducted at a frequency less than once per 12 h.Despite the severe pollution,this study confirmed the pollution resistance and treatment performance of the UF process,indicating that UF has the potential to enhance the biosecurity level.
文摘Faecal incontinence(FI) is a disabling and frequent symptom since its prevalence can vary between 5% and 15% of the general population. It has a particular negative impact on quality of life. Many tools are currently available for the treatment of FI, from conservative measures to invasive surgical treatments. The conservative treatment may be dietetic measures, various pharmacological agents, anorectal rehabilitation, posterior tibial nerve stimulation, and transanal irrigation. If needed, patients may have miniinvasive approaches such as sacral nerve modulation or antegrade irrigation. In some cases, a surgical treatment is proposed, mainly external anal sphincter repair. Although these different therapeutic options are available, new techniques are arriving allowing new hopes for the patients. Moreover, most of them are non-invasive such as local application of an α1-adrenoceptor agonist, stem cell injections, rectal injection of botulinum toxin, acupuncture. New more invasive techniques with promising results are also coming such as anal magnetic sphincter and antropylorus transposition. This review reports the main current available treatments of FI and the developing therapeutics tools.
基金financial assistance from CNPq (Brazilian National Research Council)FAPESP (S o Paulo State Research Funding Agency-Brazil) and Institut National de la Santé et de la Recherche Médicale (INSERM)+4 种基金the Aix-Marseille University (Direction des Relations Internationales)USP-COFECUB programthe ARCUS Ⅱ PACA Brésil programfunded either by the French ANR (Br-FrCHAGAS) and the Brazilian FAPESP agenciessupported by the French consulate in Brazil and the University of S o Paulo
文摘Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(T.cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of T.cruzi infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.
基金supported by Fondation pour la Recherche Médicale(Equipe FRM),SATT Sud Est-Accelerator of Technology Transfer,Association France Parkinson,Fondation de France(Committee Parkinson),COST Action CM1106
文摘Recent advances in stem cell technologies have opened new avenues for the treatment of a number of diseases still lacking effective therapeutic options.Cell transplantation has emerged as among the most promising clinical intervention for disorders such as injuries,diabetes。
文摘The electric field induced Lyman-α emission diagnostic aims to provide a non intrusive and precise measurement of the electric field in plasma, using a beam of hydrogen atoms prepared in the metastable 2 s state. The metastable particles are obtained by means of a proton beam extracted from a hydrogen plasma source, and neutralised by interaction with vaporised caesium.When a 2 s atom enters a region where an electric field is present, it undergoes a transition to the2 p state(Stark mixing). It then quickly decays to the ground level, emitting Lyman-α radiation,which is collected by a photomultiplier. The 2 s→2 p transition rate is proportional to the square of the magnitude of the electric field, and depends on the field oscillation frequency(with peaks around 1 GHz). By measuring the intensity of the Lyman-α radiation emitted by the beam it is possible to determine the magnitude of the field in a defined region. In this work, an analysis of the behaviour of the diagnostic under static or radiofrequency electric field is presented. Electric field simulations obtained with a finite element solver of Maxwell equations, combined with theoretical calculations of the Stark mixing transition rate, are used to develop a model for the interpretation of photomultiplier data. This method shows good agreement with experimental results for the static field case, and allows to measure the field magnitude for the oscillating case.
基金Financial support from the Agence Nationale de la Recherche(ANR)(Grant 15-CE40-0019)and Deutsche Forschungsgemeinschaft(DFG)(Grant SE 824/26-1),project AIFITHPC resources of IDRIS under the allocation No.2018-91664 attributed by Grand Equipement National de Calcul Intensif(GENCI)+2 种基金Centre de Calcul Intensif d'Aix-Marseille is acknowledged for granting access to its high performance computing resources financed by the project Equip@Meso(No.ANR-10-EQPX-29-01)financial support granted by the ministeres des Affaires etrangeres et du developpement international(MAEDI)et de l'Education nationale et l'enseignement superieur,de la recherche et de l'innovation(MENESRI),the Deutscher Akademischer Austauschdienst(DAAD)within the French-German Procope project FIFITfinancial support from the JSPS KAKENHI Grant No.JP18K13693。
文摘The sophisticated structures of flapping insect wings make it challenging to study the role of wing flexibility in insect flight.In this study,a mass-spring system is used to model wing structural dynamics as a thin,flexible membrane supported by a network of veins.The vein mechanical properties can be estimated based on their diameters and the Young's modulus of cuticle.In order to analyze the effect of wing flexibility,the Young's modulus is varied to make a comparison between two different wing models that we refer to as flexible and highly flexible.The wing models are coupled with a pseudo-spectral code solving the incompressible Navier–Stokes equations,allowing us to investigate the influence of wing deformation on the aerodynamic efficiency of a tethered flapping bumblebee.Compared to the bumblebee model with rigid wings,the one with flexible wings flies more efficiently,characterized by a larger lift-to-power ratio.
基金supported by the EUROfusion Enabling Research work programme 2017(Grant No.CfP-AWP17-IFE-CEA-02).
文摘We present a Stark–Zeeman spectral line-shape model and the associated numerical code,PPPB,designed to provide fast and accurate line shapes for arbitrary atomic systems for a large range of plasma conditions.PPPB is based on the coupling of the PPP code-a Stark-broadened spectral line-shape code developed for multi-electron ion spectroscopy in hot dense plasmas-and the MASCB code developed recently to generate B-field-dependent atomic physics.The latter provides energy levels,statistical weights,and reduced matrix elements of multi-electron radiators by diagonalizing the atomic Hamiltonian that includes the well know B-dependent term.These are then used as inputs to PPP working in the standard line-broadening approach,i.e.,using the quasi-static ion and impact electron approximations.The effects of ion dynamics are introduced by means of the frequency fluctuation model,and the physical model of electron broadening is based on the semi-classical impact approximation including the effects of a strong collision term,interference,and cyclotron motion.Finally,to account for polarization effects,the output profiles are calculated for a given angle of observation with respect to the direction of the magnetic field.The potential of this model is presented through Stark–Zeeman spectral line-shape calculations performed for various experimental conditions.
文摘We discuss the possibility of realizing time-resolved Kossel diffraction experiments for providing indications on the crystalline order or the periodic structure of a material.We make use of the interaction of short,ultra-intense laser pulses with a solid target,which generates short bursts of hot electrons.Penetrating inside a layered sample(i.e.,a crystal or an artificial multilayer material),these electrons ionize inner-shell electrons so that the subsequent radiative filling of K-shell vacancies results in a strong Kαemission that is enhanced in the Bragg directions corresponding to the period of the material.We present simulations of angle-resolved Kαemission,which displays so-called Kossel patterns around the Bragg angles.We then discuss possible experiments appropriate for laser facilities delivering short and intense pulses.
文摘In this study, the reproduction of the sand smelt, Atherina lagunae, from the Tunis North Lake is investigated. The smallest mature female was 39 mm total length (TL). Fifty percent of the females were mature at 58 mm (TL). The yearly and monthly average gonadosomatic indexes (GSI) are presented. The average value of GSI for the 12-month period was respectively 3.02%, 2.57% and 2.8% for females, males and both sexes. The GSI began to increase in March (2.37% for females and 2.12% for males). The maximum GSI was recorded in May, 11.29% for females and 10.03% for males. The highest values were recorded between March and July, indicating the reproduction period of Atherina lagunae in the Tunis North Lake. Similar GSI values were recorded in sand smelt males from brackish lagoons of southern France.
基金Supported by Aix-Marseille University and APHM(Assistance Publique Hopitaux de Marseille),No.CNRS(UMR#7339)
文摘AIM: To quantify the wrist cartilage cross-sectional area in humans from a 3D magnetic resonance imaging(MRI) dataset and to assess the corresponding reproducibility. METHODS: The study was conducted in 14 healthy volunteers(6 females and 8 males) between 30 and 58 years old and devoid of articular pain. Subjectswere asked to lie down in the supine position with the right hand positioned above the pelvic region on top of a home-built rigid platform attached to the scanner bed. The wrist was wrapped with a flexible surface coil. MRI investigations were performed at 3T(Verio-Siemens) using volume interpolated breath hold examination(VIBE) and dual echo steady state(DESS) MRI sequences. Cartilage cross sectional area(CSA) was measured on a slice of interest selected from a 3D dataset of the entire carpus and metacarpalphalangeal areas on the basis of anatomical criteria using conventional image processing radiology software. Cartilage cross-sectional areas between opposite bones in the carpal region were manually selected and quantified using a thresholding method.RESULTS: Cartilage CSA measurements performed on a selected predefined slice were 292.4 ± 39 mm2 using the VIBE sequence and slightly lower, 270.4 ± 50.6 mm2, with the DESS sequence. The inter(14.1%) and intra(2.4%) subject variability was similar for both MRI methods. The coefficients of variation computed for the repeated measurements were also comparable for the VIBE(2.4%) and the DESS(4.8%) sequences. The carpus length averaged over the group was 37.5 ± 2.8 mm with a 7.45% between-subjects coefficient of variation. Of note, wrist cartilage CSA measured with either the VIBE or the DESS sequences was linearly related to the carpal bone length. The variability between subjects was significantly reduced to 8.4% when the CSA was normalized with respect to the carpal bone length.CONCLUSION: The ratio between wrist cartilage CSA and carpal bone length is a highly reproducible standardized measurement which normalizes the natural diversity between individuals.
文摘We present numerical simulations of simplified models for swimming organisms or robots, using chordwise flexible elastic plates. We focus on the tip vortices originating from three-dimensional effects due to the finite span of the plate. These effects play an important role when predicting the swimmer's cruising velocity, since they contribute significantly to the drag force. First we simulate swimmers with rectangular plates of different aspect ratios and compare the results with a recent experimental study. Then we consider plates with expanding and contracting shapes. We find the cruising velocity of the contracting swimmer to be higher than the rectangular one, which in turn is higher than the expanding one. We provide some evidence that this result is due to the tip vortices interacting differently with the swimmer.