Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associa...Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associated gene.The abnormal expansion translates into a protein bearing an abnormally long tract of glutamines.展开更多
基金funded by the Portuguese Science and Technology Foundation (FCT) projectby the French Muscular Dystrophy Association(AFM-Téléthon).by the Ataxia UK+1 种基金by the CureCSB project.AndréConceicao and Rebekah Koppenol are supported by Ph.D.fellowships from FCT (DFA/BD/7892/2020SFRH/BD/148533/2019,respectively)
文摘Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associated gene.The abnormal expansion translates into a protein bearing an abnormally long tract of glutamines.
