Background Several studies have shown that afternoon napping promotes cognitive function in the elderly;on the other hand,some studies have shown opposite results.This current study further examined the relationship b...Background Several studies have shown that afternoon napping promotes cognitive function in the elderly;on the other hand,some studies have shown opposite results.This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population.Methods A total of 2214 elderly were included(napping group:n=1534;non-napping group:n=680).They all received cognitive evaluations by the Beijing version of the Montreal Cognitive Assessment,the Mini-Mental State Examination,and the Chinese version of the Neuropsychological Test Battery.Among all the subjects,739 elderly volunteered to take blood lipid tests.Results Significant differences in cognitive function and blood lipids were observed between the napping and the non-napping groups.Afternoon napping was associated with better cognitive function including orientation,language,and memory in the present study.Subjects with the habit of afternoon napping also showed a higher level of triglyceride than the non-napping subjects.Conclusion The results demonstrated that afternoon napping was related to better cognitive function in the Chinese ageing population.展开更多
Background:China has more cases of Alzheimer’s disease(AD)than any other country in the world.As training to recognize and manage dementia is in its early stage,it is important to study clinicians’current prescripti...Background:China has more cases of Alzheimer’s disease(AD)than any other country in the world.As training to recognize and manage dementia is in its early stage,it is important to study clinicians’current prescription preferences for treating patients with AD.Methods:This study surveyed neurologists,psychiatrists,and general physicians(GPs)in Shanghai who had outpatients with AD,using a questionnaire asking about their prescription preferences for these patients.Results:Among the 148 clinicians in the study,26.4%were psychiatrists,44.6%were neurologists,and 29.1%were GPs.The groups did not differ significantly in age,gender,or their monthly cases of new patients with mild or moderate AD(P>0.05).Most clinicians prescribed Cholinesterase inhibitors(ChEIs),including Huperzine A,but there were significant group-differences in prescribing specific ChEIs(P<0.05).The daily dosages of ChEI and Memantine prescribed by all three groups were small(P>0.05),and all three groups prescribed piracetam,ergot,and ginkgo biloba drugs.All three groups also tended to treat AD patients with a combination of antidepressants and anxiolytics,although psychiatrists were significantly more likely than neurologists to combine antipsychotics with other drugs(P<0.05).Conclusion:Clinicians in Shanghai prescribed low doses of ChEIs and Memantine for patients with AD.A relatively high proportion also prescribed cognitive enhancers,which lack evidence-based support of their use,and antipsychotics.There is a need for more training about treating patients with AD and for clinicians to standardize their clinical practice.展开更多
Background Prospective studies suggest that tea consumption may decrease the risk for cognitive impairment in late life.However,little research has examined the association between tea consumption and cognitive perfor...Background Prospective studies suggest that tea consumption may decrease the risk for cognitive impairment in late life.However,little research has examined the association between tea consumption and cognitive performance across multiple domains.In addition,no research has examined the benefit of tea consumption on cognitive performance among older adults with existing impairment.Aims The current study examined the association between tea consumption and performance on tasks of global cognitive function,episodic memory and executive function in cognitively healthy(CH)older adults and older adults with mild cognitive impairment(MCI).Methods The analytical sample included 1849 community-dwelling older adults from the Shanghai Brain Aging Study(65.6%female,mean age of 69.50(8.02)years).Following ascertainment of cognitive function,816 were categorised as MCI.In addition to completion of a demographics questionnaire,participants reported their tea consumption and completed a battery of tests to measure global cognitive function,episodic memory and working memory.Results Independent analyses of covariance revealed a significant association between tea consumption and measures of episodic memory;however,these associations were restricted to CH older adults but not older adults with MCI.Tea consumption was not associated with working memory performance.Conclusions The current study suggests that the benefit of tea consumption is restricted to cognitively healthy older adults and does not extend to older adults with MCI.展开更多
The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property.It has been shown that α-mangostin(αM)-loaded poly(ethyle...The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property.It has been shown that α-mangostin(αM)-loaded poly(ethylene glycol)-poly(l-lactide)(PEG-PLA)nanoparticles(NP-αM)specifically increased low density lipoprotein receptor(LDLR)expression in microglia and improved clearance of amyloid beta(Aβ)after multiple administration.However,how do the nanoparticles cross the blood‒brain barrier and access microglia remain unknown.Here,we studied the brain delivery property of PEG-PLA nanoparticles under different conditions,finding that the nanoparticles exhibited higher brain transport efficiency and microglia uptake efficiency afterαM loading and multiple administration.To reveal the mechanism,we performed proteomic analysis to characterize the composition of protein corona formed under various conditions,finding that both drug loading and multiple dosing affect the composition of protein corona and subsequently influence the cellular uptake of nanoparticles in b.End3 and BV-2 cells.Complement proteins,immunoglobulins,RAB5A and CD36 were found to be enriched in the corona and associated with the process of nanoparticles uptake.Collectively,we bring a mechanistic understanding about the modulator role of protein corona on targeted drug delivery,and provide theoretical basis for engineering brain or microglia-specific targeted delivery system.展开更多
基金This study was funded by grants from the clinical research center project of Shanghai Mental Health Center(CRC2017ZD02)Western medical guidance project of Shanghai Science and Technology Commission(17411970100)+1 种基金National Natural Science Foundation of China(81301139)Precision medical research project of Shanghai Jiao Tong University School of Medicine(15ZH4010).
文摘Background Several studies have shown that afternoon napping promotes cognitive function in the elderly;on the other hand,some studies have shown opposite results.This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population.Methods A total of 2214 elderly were included(napping group:n=1534;non-napping group:n=680).They all received cognitive evaluations by the Beijing version of the Montreal Cognitive Assessment,the Mini-Mental State Examination,and the Chinese version of the Neuropsychological Test Battery.Among all the subjects,739 elderly volunteered to take blood lipid tests.Results Significant differences in cognitive function and blood lipids were observed between the napping and the non-napping groups.Afternoon napping was associated with better cognitive function including orientation,language,and memory in the present study.Subjects with the habit of afternoon napping also showed a higher level of triglyceride than the non-napping subjects.Conclusion The results demonstrated that afternoon napping was related to better cognitive function in the Chinese ageing population.
基金This study was supported by grants for National Key Clinical Disciplines to the Shanghai Mental Health Center(Office of Medical Affairs,Ministry of Health,2011–873,OMA-MH,2011–873)the Shanghai Clinical Center for Mental Disorders(2014),Shanghai Science&Technology Committee(No.15411961400).
文摘Background:China has more cases of Alzheimer’s disease(AD)than any other country in the world.As training to recognize and manage dementia is in its early stage,it is important to study clinicians’current prescription preferences for treating patients with AD.Methods:This study surveyed neurologists,psychiatrists,and general physicians(GPs)in Shanghai who had outpatients with AD,using a questionnaire asking about their prescription preferences for these patients.Results:Among the 148 clinicians in the study,26.4%were psychiatrists,44.6%were neurologists,and 29.1%were GPs.The groups did not differ significantly in age,gender,or their monthly cases of new patients with mild or moderate AD(P>0.05).Most clinicians prescribed Cholinesterase inhibitors(ChEIs),including Huperzine A,but there were significant group-differences in prescribing specific ChEIs(P<0.05).The daily dosages of ChEI and Memantine prescribed by all three groups were small(P>0.05),and all three groups prescribed piracetam,ergot,and ginkgo biloba drugs.All three groups also tended to treat AD patients with a combination of antidepressants and anxiolytics,although psychiatrists were significantly more likely than neurologists to combine antipsychotics with other drugs(P<0.05).Conclusion:Clinicians in Shanghai prescribed low doses of ChEIs and Memantine for patients with AD.A relatively high proportion also prescribed cognitive enhancers,which lack evidence-based support of their use,and antipsychotics.There is a need for more training about treating patients with AD and for clinicians to standardize their clinical practice.
基金This work was supported by the Science and Technology Commission of Shanghai Municipality(grant number 18411961500,19MC1911100)Shanghai Health Committee(grant number 202040366)+3 种基金the Shanghai Mental Health Center(grant number 2017-YJ-12,CRC2017ZD02)Shanghai Jiao Tong University School of Medicine(15ZH4010)Shanghai Brain Health Foundation(SHBHF2016001)Shanghai Jiao Tong University School of Medicine and Institute of Neuroscience,Chinese Academy of Sciences(2015NKX003).
文摘Background Prospective studies suggest that tea consumption may decrease the risk for cognitive impairment in late life.However,little research has examined the association between tea consumption and cognitive performance across multiple domains.In addition,no research has examined the benefit of tea consumption on cognitive performance among older adults with existing impairment.Aims The current study examined the association between tea consumption and performance on tasks of global cognitive function,episodic memory and executive function in cognitively healthy(CH)older adults and older adults with mild cognitive impairment(MCI).Methods The analytical sample included 1849 community-dwelling older adults from the Shanghai Brain Aging Study(65.6%female,mean age of 69.50(8.02)years).Following ascertainment of cognitive function,816 were categorised as MCI.In addition to completion of a demographics questionnaire,participants reported their tea consumption and completed a battery of tests to measure global cognitive function,episodic memory and working memory.Results Independent analyses of covariance revealed a significant association between tea consumption and measures of episodic memory;however,these associations were restricted to CH older adults but not older adults with MCI.Tea consumption was not associated with working memory performance.Conclusions The current study suggests that the benefit of tea consumption is restricted to cognitively healthy older adults and does not extend to older adults with MCI.
基金This work was supported by National Natural Science Foundation of China(No.81722043,92068111,81973272,81803089,81903582,82073836)National Science and Technology Major Project(2018ZX09734005,2017ZX09304016,China)grant from Shanghai Science and Technology Committee(19410710100,18YF1413400,China).
文摘The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property.It has been shown that α-mangostin(αM)-loaded poly(ethylene glycol)-poly(l-lactide)(PEG-PLA)nanoparticles(NP-αM)specifically increased low density lipoprotein receptor(LDLR)expression in microglia and improved clearance of amyloid beta(Aβ)after multiple administration.However,how do the nanoparticles cross the blood‒brain barrier and access microglia remain unknown.Here,we studied the brain delivery property of PEG-PLA nanoparticles under different conditions,finding that the nanoparticles exhibited higher brain transport efficiency and microglia uptake efficiency afterαM loading and multiple administration.To reveal the mechanism,we performed proteomic analysis to characterize the composition of protein corona formed under various conditions,finding that both drug loading and multiple dosing affect the composition of protein corona and subsequently influence the cellular uptake of nanoparticles in b.End3 and BV-2 cells.Complement proteins,immunoglobulins,RAB5A and CD36 were found to be enriched in the corona and associated with the process of nanoparticles uptake.Collectively,we bring a mechanistic understanding about the modulator role of protein corona on targeted drug delivery,and provide theoretical basis for engineering brain or microglia-specific targeted delivery system.
