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Efficacy and Safety of Dexmedetomidine during Anesthesia Induction of Patients with Intracranial Tumor: A Preliminary Observational Trial 被引量:2
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作者 Jiangbei Cao Wenzhu Shi +1 位作者 Weidong Mi Hong Zhang 《Pharmacology & Pharmacy》 2013年第8期584-589,共6页
Background: The efficacy and safety of dexmedetomidine during the anesthesia induction of intracranial tumor patients remain unknown. We wondered whether loading infusion of dexmedetomidine 1 μg/kg over 10 min to int... Background: The efficacy and safety of dexmedetomidine during the anesthesia induction of intracranial tumor patients remain unknown. We wondered whether loading infusion of dexmedetomidine 1 μg/kg over 10 min to intracranial tumor patients was as efficient and safe as to those abdominal disease patients. Methods: Patients aged 18-60 years, male or female, ASA I or II, scheduled for intracranial tumor resection (Group N, n = 30) or abdominal operation (Group A, n = 30) were enrolled in this observational trial. Dexmedetomidine was administrated with a loading dosage of 1 μg/kg over 10 min following with continuous infusing of 0.5 μg/kg/h. Fentanyl, propofol and rocuronium were sequentially administered for anesthesia induction. Heart rate (HR), blood pressure (BP), pulse oxygen saturation (SpO2), bispectral index (BIS) and other adverse effects were recorded from the beginning of loading infusion of dexmedetomidine to the end of endotracheal intubation. Results: Among with loading infusion, HR and BIS value decreased and were significantly lower at the end of infusion than before infusion (P P > 0.05). One patient of Group N dropped out from this trial because of a serious headache. 14 of 29 patients during dexmedetomidine loading infusion suffered hypoxemia (SpO2 P Conclusion: A loading dosage of 1 μg/kg of dexmedetomidine was not suitable for the anesthesia induction of intracranial tumor patients as compared to patients undergoing abdominal operation. 展开更多
关键词 DEXMEDETOMIDINE INTRACRANIAL Tumor ADVERSE Effects Loading INFUSION
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Prevention and control strategies for emergency,limited-term,and elective operations in pediatric surgery during the epidemic period of COVID-19 被引量:1
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作者 Daxing Tang Jinfa Tou +9 位作者 Jinhu Wang Qingjiang Chen Wei Wang Jinjin Huang Hangyan Zhao Jia Wei Zheming Xu Dongyan Zhao Junfen Fu Qiang Shu 《World Journal of Pediatric Surgery》 2020年第1期39-45,共7页
The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread to more than 100 countries.Children approved to be susceptible to SARS-CoV-2 infection.... The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread to more than 100 countries.Children approved to be susceptible to SARS-CoV-2 infection.Preventing and controlling the epidemic while ensuring orderly flows of pediatric surgery clinical work has proven to be a big challenge for both patients and clinicians during the epidemic.Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19,the authors proposed some concrete measures and practical strategies of managing emergency,limited-term,and elective pediatric surgeries during the epidemic period. 展开更多
关键词 PEDIATRIC surgery prevention
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