Portal hypertension caused by non-cirrhotic(and non neoplastic)splanchnic vein thrombosis(NC-SVT)is responsible for 5–10%of portal hypertension cases in the western world(1).Chronic myeloproliferative neoplasms(MPN)o...Portal hypertension caused by non-cirrhotic(and non neoplastic)splanchnic vein thrombosis(NC-SVT)is responsible for 5–10%of portal hypertension cases in the western world(1).Chronic myeloproliferative neoplasms(MPN)or systemic prothrombotic disorders are in cause in about 40%of subjects,while in about 30%a local condition,such as recent abdominal surgery or infection/inflammation triggers the event.The local condition,however,can only be the precipitating cause,since a thorough screening allows identifying the co-occurrence of systemic thrombophilia in about 30%of such cases.Hence,screening is mandatory even in cases where the cause of NC-SVT seems obvious.Nevertheless,about 30%of cases of NC-SVT remains unexplained and defined idiopathic(1).展开更多
Frailty is a multidimensional dynamic condition characterized by decreased physiological reserves. Therefore,frail people are more vulnerable to stressors.Indeed,minor stimuli,like a new drug prescription,can alter th...Frailty is a multidimensional dynamic condition characterized by decreased physiological reserves. Therefore,frail people are more vulnerable to stressors.Indeed,minor stimuli,like a new drug prescription,can alter their homeostatic equilibrium determining adverse clinical outcomes(i.e.,falls,institutionalization,disability,and death).[1,2]Since the risk of atrial fibrillation[3]and venous thromboembolism[4]increase with ageing,frail people might require long term anticoagulation.展开更多
文摘Portal hypertension caused by non-cirrhotic(and non neoplastic)splanchnic vein thrombosis(NC-SVT)is responsible for 5–10%of portal hypertension cases in the western world(1).Chronic myeloproliferative neoplasms(MPN)or systemic prothrombotic disorders are in cause in about 40%of subjects,while in about 30%a local condition,such as recent abdominal surgery or infection/inflammation triggers the event.The local condition,however,can only be the precipitating cause,since a thorough screening allows identifying the co-occurrence of systemic thrombophilia in about 30%of such cases.Hence,screening is mandatory even in cases where the cause of NC-SVT seems obvious.Nevertheless,about 30%of cases of NC-SVT remains unexplained and defined idiopathic(1).
文摘Frailty is a multidimensional dynamic condition characterized by decreased physiological reserves. Therefore,frail people are more vulnerable to stressors.Indeed,minor stimuli,like a new drug prescription,can alter their homeostatic equilibrium determining adverse clinical outcomes(i.e.,falls,institutionalization,disability,and death).[1,2]Since the risk of atrial fibrillation[3]and venous thromboembolism[4]increase with ageing,frail people might require long term anticoagulation.
