DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The mai...DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The main function of mitochondria is to produce energy in the form of ATP,which is vital to fulfill high energy demand of neurons,mainly for synaptic processes(Lee et al.,2018).Mitochondrial dysfunction acts as a key factor for age-related cognitive decline(Grimm and Eckert,2017).展开更多
Epigenetic mechanisms,including DNA methylation,histone modification,and non-coding RNAs(ncRNAs),have been widely implicated in synaptic plasticity,memory formation,and memory consolidation.Dysregulation in epigenetic...Epigenetic mechanisms,including DNA methylation,histone modification,and non-coding RNAs(ncRNAs),have been widely implicated in synaptic plasticity,memory formation,and memory consolidation.Dysregulation in epigenetic mechanisms has been reported in aged brains as well as age-related diseases,such as Alzheimer’s disease(AD).The reversible nature of epigenetic changes and their role in regulating gene expression in response to environmental stimuli make them exciting targets for therapy.Here,we will briefly discuss epigenetic changes in aged and AD brains,epigenetic biomarkers for diagnosis and prognosis,as well as HDAC-based treatment regimes.展开更多
The mechanisms underlying learning and memory have been a longstanding focus of neuroscience research.In recent decades,there has been a substantial increase in the investigation and understanding of the intricate mol...The mechanisms underlying learning and memory have been a longstanding focus of neuroscience research.In recent decades,there has been a substantial increase in the investigation and understanding of the intricate molecular processes involved in learning and memory.Epigenetic mechanisms,which encompass dynamic and reversible modifications at various levels of cellular regulation.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.82125009,U19A2034,31871082,91849101,32121002,82071185,32100794 and 92149303)the National Key R&D Program of China (2020YFA0509300,2021YFA0804900)+4 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000)CAS Project for Young Scientists in Basic Research (YSBR-013)Collaborative Innovation Program of Hefei Science Center,CAS (2022HSC-CIP003)the Fundamental Research Funds for the Central Universities (YD2070002011,WK2070000168)Institute of Health and Medicine,Hefei Comprehensive National Science Center (QYZD20220003).
文摘DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The main function of mitochondria is to produce energy in the form of ATP,which is vital to fulfill high energy demand of neurons,mainly for synaptic processes(Lee et al.,2018).Mitochondrial dysfunction acts as a key factor for age-related cognitive decline(Grimm and Eckert,2017).
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+3 种基金the National Natural Science Foundation of China(82030034,32121002,and 81971123)CAMS Innovation Fund for Medical Sciences(2021-I2M-C&T-B-012)the Fundamental Research Funds for the Central Universities(YD9110002027)the Guangzhou Key Research Program on Brain Science(202007030008)。
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)the Fundamental Research Funds for the Central Universities(YD9100002033)+1 种基金the Hefei Comprehensive National Science Center Hefei Brain Projectthe Natural Science Foundation of Anhui Province(2308085QH265)。
基金supported by the National Natural Science Foundation of China(82125009,31871082,91849101,32121002,82071185,32100794,and 92149303)the National Key R&D Program of China(2020YFA0509300 and 2021YFA0804900)+3 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)CAS Project for Young Scientists in Basic Research(YSBR-013)the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003)the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003)。
文摘Epigenetic mechanisms,including DNA methylation,histone modification,and non-coding RNAs(ncRNAs),have been widely implicated in synaptic plasticity,memory formation,and memory consolidation.Dysregulation in epigenetic mechanisms has been reported in aged brains as well as age-related diseases,such as Alzheimer’s disease(AD).The reversible nature of epigenetic changes and their role in regulating gene expression in response to environmental stimuli make them exciting targets for therapy.Here,we will briefly discuss epigenetic changes in aged and AD brains,epigenetic biomarkers for diagnosis and prognosis,as well as HDAC-based treatment regimes.
基金supported by the National Natural Science Foundation of China(82125009,31871082,91849101,32121002,82071185,32100794,and 92149303)the National Key R&D Program of China(2020YFA0509300 and 2021YFA0804900)+5 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)CAS Project for Young Scientists in Basic Research(YSBR-013)the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003)the Anhui Provincial Natural Science Foundation(2008085QC117)the Fundamental Research Funds for the Central Universities(YD2070002011 and WK2070000168)the Institute of Health and Medicine,Hefei Comprehensive National Science Center(QYZD20220003)。
文摘The mechanisms underlying learning and memory have been a longstanding focus of neuroscience research.In recent decades,there has been a substantial increase in the investigation and understanding of the intricate molecular processes involved in learning and memory.Epigenetic mechanisms,which encompass dynamic and reversible modifications at various levels of cellular regulation.
