In the present study,we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods.Specifically,lipoic acid-modified Oseltami...In the present study,we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods.Specifically,lipoic acid-modified Oseltamivir(OS),which is a strong neuraminidase inhibitor and used as the first-line drug in the treatment of influenza,was synthesized and further attached to the surface of gold nanorods(OS-LA-GNRs).The absorption band and density of OS-LA-GNRs were changed with the decreasing distance between the nanoparticles induced by the target-specific aggregation via strong neuraminidase–OS binding.All of these could be visible with the naked eyes and measured by UV-visible spectrophotometry.The results showed that our system had a comparable limit of detection(LOD)to the commercial colloidal gold stripes,making it feasible for wide diagnostic applications.展开更多
基金Natural Science Foundation of China(Grant No.81773583)Tackling Key Research Project for New Corona Virus Prevention and Treatment of Tianjin University of Science&Technology(Grant No.2020STCV0019)。
文摘In the present study,we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods.Specifically,lipoic acid-modified Oseltamivir(OS),which is a strong neuraminidase inhibitor and used as the first-line drug in the treatment of influenza,was synthesized and further attached to the surface of gold nanorods(OS-LA-GNRs).The absorption band and density of OS-LA-GNRs were changed with the decreasing distance between the nanoparticles induced by the target-specific aggregation via strong neuraminidase–OS binding.All of these could be visible with the naked eyes and measured by UV-visible spectrophotometry.The results showed that our system had a comparable limit of detection(LOD)to the commercial colloidal gold stripes,making it feasible for wide diagnostic applications.
