Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces.It is a complex combination of tissue regeneration,granulation tissue hy...Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces.It is a complex combination of tissue regeneration,granulation tissue hyperplasia,and scar formation,and shows the synergistic effects of these processes.After skin damage,the environment around the wound and the cells at site of the damage respond immediately,and a range of cytokines and growth factors are released.In cutaneous injury,extracellular vesicle(EV)signaling plays a vital role in the healing process via paracrine and endocrine mechanisms.EVs are natural intercellular and inter-organ communication tools that carry various bioactive substances for message exchange.Stem cells and stem cell EVs facilitate tissue repair,showing promising potential in regenerative medicine.Nevertheless,EVs derived from specific skin tissue cells,such as epidermal cells,fibroblasts,vascular endothelial cells and inflammatory cells,also play important roles in cutaneous tissue repair.Here,we describe the characteristics of wound healing,concentrating on the production and functions of EVs derived from specific skin cells,and provide new ideas for wound therapy using EVs.展开更多
基金supported by the National Natural Science Youth Foundation of China(Grant 82001975)the Natural Science Youth Foundation of the Jiangsu Province(Grant BK20190841)+4 种基金Jiangsu Province‘Entrepreneurship and Innovation Program’-Entrepreneurship and innovation Doctoral category.Top Talent Support Program for young and middle-aged people of Wuxi Health Committee(HB2020108)The Foundation of Clinical Science and Technology of Wuxi(No.Q202059)The Natural Science Youth Foundation of the Jiangsu Province(Grant BK20210074)The Innovation Fund on Medicine and Education Connection of Jiangsu University(JDY2022017)The Innovation Project for Graduate Student Research of Jiangsu Province(Grant No.KYCX21_3406).
文摘Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces.It is a complex combination of tissue regeneration,granulation tissue hyperplasia,and scar formation,and shows the synergistic effects of these processes.After skin damage,the environment around the wound and the cells at site of the damage respond immediately,and a range of cytokines and growth factors are released.In cutaneous injury,extracellular vesicle(EV)signaling plays a vital role in the healing process via paracrine and endocrine mechanisms.EVs are natural intercellular and inter-organ communication tools that carry various bioactive substances for message exchange.Stem cells and stem cell EVs facilitate tissue repair,showing promising potential in regenerative medicine.Nevertheless,EVs derived from specific skin tissue cells,such as epidermal cells,fibroblasts,vascular endothelial cells and inflammatory cells,also play important roles in cutaneous tissue repair.Here,we describe the characteristics of wound healing,concentrating on the production and functions of EVs derived from specific skin cells,and provide new ideas for wound therapy using EVs.
