Using ultrasonography we found multiple sites with nerve enlargement along the course of the brachial plexus, median, ulnar, and radial nerves in the majority of 21 patients with multifocal motor neuropathy. Sonograph...Using ultrasonography we found multiple sites with nerve enlargement along the course of the brachial plexus, median, ulnar, and radial nerves in the majority of 21 patients with multifocal motor neuropathy. Sonography and electrophysiologic studies showed more abnormalities than expected on purely clinical grounds. Moreover, sonography revealed nerve enlargement without clinical or electrophysiologic abnormalities.展开更多
Compensating for fluorescence overlap in multiparameter flow cytometry datasets, of which one parameter is linear distributed and at least one parameter is logarithmic distributed, leads usually to extreme high compen...Compensating for fluorescence overlap in multiparameter flow cytometry datasets, of which one parameter is linear distributed and at least one parameter is logarithmic distributed, leads usually to extreme high compensation values. We investigated this phenomenon with an adapted flow cytometry model, of which the two parameters can easily be converted from linear to logarithmic and vice versa. With the adapted model, spectral compensation was performed both for linear-logarithmic and linear-linear parameter distribution. The results of the flow cytometry model were validated with a real world example which was also compensated twice. The results of the two experiments show that the compensation values equal to the theoretically expected value when both parameters are linear distributed. However, the compensation value exceeds 100% when one of the two parameters is logarithmic distributed. In addition, we found that spectral compensation of differently distributed parameters leads to deformation of the compensated events. With the adapted flow cytometry model presented in this paper it is shown how to correctly compensate flow cytometry acquisitions with different distributed parameters.展开更多
OBJECTIVES: This study sought to evaluate the predictive value of baseline placental growth factor(PlGF) for long-term cardiovascular events in acute coronary syndromes(ACS). BACKGROUND: A biomarker of vascular inflam...OBJECTIVES: This study sought to evaluate the predictive value of baseline placental growth factor(PlGF) for long-term cardiovascular events in acute coronary syndromes(ACS). BACKGROUND: A biomarker of vascular inflammation, PlGF is identified as a powerful predictor for short-term outcome in patients with ACS. METHODS: In 544 patients who were enrolled in the placebo arm of the c7E3 Fab Anti Platelet Therapy in Unstable REfractory angina(CAPTURE) trial, PlGF levels were determined as well as markers of myocardial necrosis(troponin T[TnT]), general inflammation(high-sensitivity Creactive protein[hsCRP]), and platelet activation(soluble CD40 ligand[sCD40L]). Cox proportional hazard regression analyses were applied to evaluate the relationship between biomarkers and the occurrence of all-cause death or non-fatal myocardial infarction during a median follow-up period of four years. RESULTS: Patients with PlGF levels in the fourth and fifth quintile(>27 ng/l) had higher mortality than those with lower levels(10.8% vs. 3.2% ; hazard ratio[HR], 3.3; 95% confidence interval[CI], 1.6 to 7.1), as well as a higher incidence of the composite end point of death or myocardial infarction(27.6% vs. 11.3% events;HR, 2.6; 95% CI, 1.7 to 3.9). The relationship between PlGF and the composite end point remained significant after adjustment for TnT, sCD40L, and hsCRP(adjusted HR, 3.3; 95% CI, 2.0 to 5.4). CONCLUSIONS: In patients with ACS, elevated plasma levels of PlGF are associated with adverse cardiac outcomes during long-term follow-up. These data suggest that PlGF as a more specific marker of vascular inflammation should be considered for risk stratification of patients with ACS rather than general markers of inflammation.展开更多
Objective: To test the hypothesis that in pregnancies with a clinically suspected growth restricted foetus at term, induction of labour is as safe as expectant management, and does not lead to increased obstetrical in...Objective: To test the hypothesis that in pregnancies with a clinically suspected growth restricted foetus at term, induction of labour is as safe as expectant management, and does not lead to increased obstetrical interventions or perinatal morbidity. Study design: In one obstetric centre, 33 women with a clinically suspected growth restricted foetus at term were randomly allocated after stratification for parity to either induction or to expectant management. Obstetric and neonatal outcome variables were compared. Results: There was a lower gestational age at labour (median 380 weeks versus 401 weeks) with a corresponding tendency to lower birth weight (mean 2428 g versus 2651 g), and a reduced need for ante partum medical surveillance, in the induction group. No significant differences in obstetrical interventions (25% versus 24% ) and neonatal morbidity rates (50% versus 35% ) were found. Conclusion: A larger multicenter study with a sufficient power and long-term follow-up to decide the best policy for the term growth restricted foetus is feasible.展开更多
We describe a 36 year old woman with progressive bila teral ulnar neuropathy. Sonographic and magnetic resonance imaging studies revealed extensive focal ulnar nerve enlargement at the elbow. Histological studies gave...We describe a 36 year old woman with progressive bila teral ulnar neuropathy. Sonographic and magnetic resonance imaging studies revealed extensive focal ulnar nerve enlargement at the elbow. Histological studies gave evidence of an intraneural perineurioma. Because intraneural perineurioma usually appears as a single mass lesion at sites other than typical entrapment sites, this mode of presentation is unusual. We discuss the nature of this benign tumor and the differential diagnosis of nerve enlargement. Knowledge of possible causes of nerve thickening is crucial when performing imaging in patients with neuropathies.展开更多
文摘Using ultrasonography we found multiple sites with nerve enlargement along the course of the brachial plexus, median, ulnar, and radial nerves in the majority of 21 patients with multifocal motor neuropathy. Sonography and electrophysiologic studies showed more abnormalities than expected on purely clinical grounds. Moreover, sonography revealed nerve enlargement without clinical or electrophysiologic abnormalities.
文摘Compensating for fluorescence overlap in multiparameter flow cytometry datasets, of which one parameter is linear distributed and at least one parameter is logarithmic distributed, leads usually to extreme high compensation values. We investigated this phenomenon with an adapted flow cytometry model, of which the two parameters can easily be converted from linear to logarithmic and vice versa. With the adapted model, spectral compensation was performed both for linear-logarithmic and linear-linear parameter distribution. The results of the flow cytometry model were validated with a real world example which was also compensated twice. The results of the two experiments show that the compensation values equal to the theoretically expected value when both parameters are linear distributed. However, the compensation value exceeds 100% when one of the two parameters is logarithmic distributed. In addition, we found that spectral compensation of differently distributed parameters leads to deformation of the compensated events. With the adapted flow cytometry model presented in this paper it is shown how to correctly compensate flow cytometry acquisitions with different distributed parameters.
文摘OBJECTIVES: This study sought to evaluate the predictive value of baseline placental growth factor(PlGF) for long-term cardiovascular events in acute coronary syndromes(ACS). BACKGROUND: A biomarker of vascular inflammation, PlGF is identified as a powerful predictor for short-term outcome in patients with ACS. METHODS: In 544 patients who were enrolled in the placebo arm of the c7E3 Fab Anti Platelet Therapy in Unstable REfractory angina(CAPTURE) trial, PlGF levels were determined as well as markers of myocardial necrosis(troponin T[TnT]), general inflammation(high-sensitivity Creactive protein[hsCRP]), and platelet activation(soluble CD40 ligand[sCD40L]). Cox proportional hazard regression analyses were applied to evaluate the relationship between biomarkers and the occurrence of all-cause death or non-fatal myocardial infarction during a median follow-up period of four years. RESULTS: Patients with PlGF levels in the fourth and fifth quintile(>27 ng/l) had higher mortality than those with lower levels(10.8% vs. 3.2% ; hazard ratio[HR], 3.3; 95% confidence interval[CI], 1.6 to 7.1), as well as a higher incidence of the composite end point of death or myocardial infarction(27.6% vs. 11.3% events;HR, 2.6; 95% CI, 1.7 to 3.9). The relationship between PlGF and the composite end point remained significant after adjustment for TnT, sCD40L, and hsCRP(adjusted HR, 3.3; 95% CI, 2.0 to 5.4). CONCLUSIONS: In patients with ACS, elevated plasma levels of PlGF are associated with adverse cardiac outcomes during long-term follow-up. These data suggest that PlGF as a more specific marker of vascular inflammation should be considered for risk stratification of patients with ACS rather than general markers of inflammation.
文摘Objective: To test the hypothesis that in pregnancies with a clinically suspected growth restricted foetus at term, induction of labour is as safe as expectant management, and does not lead to increased obstetrical interventions or perinatal morbidity. Study design: In one obstetric centre, 33 women with a clinically suspected growth restricted foetus at term were randomly allocated after stratification for parity to either induction or to expectant management. Obstetric and neonatal outcome variables were compared. Results: There was a lower gestational age at labour (median 380 weeks versus 401 weeks) with a corresponding tendency to lower birth weight (mean 2428 g versus 2651 g), and a reduced need for ante partum medical surveillance, in the induction group. No significant differences in obstetrical interventions (25% versus 24% ) and neonatal morbidity rates (50% versus 35% ) were found. Conclusion: A larger multicenter study with a sufficient power and long-term follow-up to decide the best policy for the term growth restricted foetus is feasible.
文摘We describe a 36 year old woman with progressive bila teral ulnar neuropathy. Sonographic and magnetic resonance imaging studies revealed extensive focal ulnar nerve enlargement at the elbow. Histological studies gave evidence of an intraneural perineurioma. Because intraneural perineurioma usually appears as a single mass lesion at sites other than typical entrapment sites, this mode of presentation is unusual. We discuss the nature of this benign tumor and the differential diagnosis of nerve enlargement. Knowledge of possible causes of nerve thickening is crucial when performing imaging in patients with neuropathies.
