Objective: Evaluating the auditory function in patients with chronic hepatitis C treated with sofosbuvir and ribavirin.Methods: This study involved 80 patients with chronic hepatitis C who agreed to receive sofosbuvir...Objective: Evaluating the auditory function in patients with chronic hepatitis C treated with sofosbuvir and ribavirin.Methods: This study involved 80 patients with chronic hepatitis C who agreed to receive sofosbuvir and ribavirin. All participants were subjected to baseline otological and audiological assessment just before treatment. The audiological assessment included standard pure tone audiometry, extended highfrequency audiometry, immitancemetry and otoacoustic emissions(OAEs)(transient and distortion product). According to baseline hearing threshold measurements, the study population was divided into2 groups. Group 1 included 42 patients with normal hearing sensitivity(250-8000 Hz), and Group 2 included 38 patients with sensorineural hearing loss. After 24 weeks of therapy, otological and audiological assessments were repeated and compared between the two groups and before and after therapy.Results: Post-treatment hearing threshold evaluation showed no significant difference from pretreatment evaluation at all tested frequencies. There was no statistically significant difference between pre and post-treatment otoacoustic emissions results.Conclusion: Therapy with sofosbuvir and ribavirin in chronic hepatitis C has no noticeable effects on cochlear functions.展开更多
文摘Objective: Evaluating the auditory function in patients with chronic hepatitis C treated with sofosbuvir and ribavirin.Methods: This study involved 80 patients with chronic hepatitis C who agreed to receive sofosbuvir and ribavirin. All participants were subjected to baseline otological and audiological assessment just before treatment. The audiological assessment included standard pure tone audiometry, extended highfrequency audiometry, immitancemetry and otoacoustic emissions(OAEs)(transient and distortion product). According to baseline hearing threshold measurements, the study population was divided into2 groups. Group 1 included 42 patients with normal hearing sensitivity(250-8000 Hz), and Group 2 included 38 patients with sensorineural hearing loss. After 24 weeks of therapy, otological and audiological assessments were repeated and compared between the two groups and before and after therapy.Results: Post-treatment hearing threshold evaluation showed no significant difference from pretreatment evaluation at all tested frequencies. There was no statistically significant difference between pre and post-treatment otoacoustic emissions results.Conclusion: Therapy with sofosbuvir and ribavirin in chronic hepatitis C has no noticeable effects on cochlear functions.
