BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical signifi...BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective.展开更多
A new basic dodecapeptide BPP was isolated from the water-extract of the buckwheat pollen (BP). The sequence of BPP, which was first reported, was determined by DABITC/PITC double coupling method, and confirmed by che...A new basic dodecapeptide BPP was isolated from the water-extract of the buckwheat pollen (BP). The sequence of BPP, which was first reported, was determined by DABITC/PITC double coupling method, and confirmed by chemical synthesis. Some analogues of BPP were also synthesized by SPPS Method. The effect of these peptides on spleen lymphocytes from mice of Kunming inbred line and on release of SIL-2R from human lymphocytes were studied. The results showed that these peptides exhibit certain immune activity.展开更多
Background Hyperbaric oxygen preconditioning （HBO） is a new method of ischemia preconditioning. In this study, we examined its effects on skin flap survival and the mechanisms involved. Methods Thirty-six rats were ...Background Hyperbaric oxygen preconditioning （HBO） is a new method of ischemia preconditioning. In this study, we examined its effects on skin flap survival and the mechanisms involved. Methods Thirty-six rats were divided into three groups： HBO preconditioning, control, and sham groups. An extended epigastric adipocutaneous flap based on the right superficial epigastric artery and vein was raised. A 3-hour period of flap ischemia was induced by clamping the pedicle vessels with a microvascular clamp. At the end of ischemia induction, the clamp was removed and the flap was resutured. Rats in the HBO preconditioning group were treated with HBO four times before surgery. Microcirculation in the skin flap was measured on postoperative days 1, 3 and 5. The size of the flap was measured on postoperative day 5, before the animals were sacrificed. Samples of the skin flap were prepared and stained with hematoxylin and eosin. The levels of tumor necrosis factor （TNF）-α, interleukin （IL）-1β, and IL-6 in the flap samples were measured.展开更多
To the editor： The diagnosis of juvenile dermatomyositis （JDM） is much more challenging when lacking the cutaneous naanifestations as well as muscular biomarkers. Here we report an interesting case of J DM.
Chinese arthroplasty has made great progresses since the 1970 s, treating almost all the diarthrosis from hip to knee, shoulder, elbow, ankle and interphalangeal joints. Hip and knee, among them, are the most represe...Chinese arthroplasty has made great progresses since the 1970 s, treating almost all the diarthrosis from hip to knee, shoulder, elbow, ankle and interphalangeal joints. Hip and knee, among them, are the most representative ones.展开更多
The Freeman-Sheldon syndrome （FSS） is a rare congenital syndrome,characterized with myopathy and dysplasia.The musculoskeletal and soft-tissue manifestations often require orthopedic and plastic surgery.We reported ...The Freeman-Sheldon syndrome （FSS） is a rare congenital syndrome,characterized with myopathy and dysplasia.The musculoskeletal and soft-tissue manifestations often require orthopedic and plastic surgery.We reported a case of 8-year-old girl with FSS operated on for scoliosis.展开更多
To the editor： Merkel cell carcinoma （MCC） is an extremely rare primary neuroendocrine neoplasm of the skin. It occurs more frequently in elderly and immunosuppresed individuals with a male predominance,l Merkel ce...To the editor： Merkel cell carcinoma （MCC） is an extremely rare primary neuroendocrine neoplasm of the skin. It occurs more frequently in elderly and immunosuppresed individuals with a male predominance,l Merkel cell polyomavirus （MCPyV） has been recently associated with MCC, which was described as one of 7 known human oncogenic viruses.2 MCC is characterized by early and rapid metastases, although there are some reported cases with spontaneous regression.3 Mobs micrographic surgery should be considered fbr treatment of MCC. However, successful treatment still lies in diagnosis and therapy at the early stage of disease, consisting of regular dermatological checkups in older immunocompromised individuals, and early initiation of combination therapy including radical surgical treatment, radiotherapy, and chemotherapy.展开更多
基金This study was supported by a grant from Clinical Subject of Ministry of Health of China (2004-2006-2).
文摘BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective.
文摘A new basic dodecapeptide BPP was isolated from the water-extract of the buckwheat pollen (BP). The sequence of BPP, which was first reported, was determined by DABITC/PITC double coupling method, and confirmed by chemical synthesis. Some analogues of BPP were also synthesized by SPPS Method. The effect of these peptides on spleen lymphocytes from mice of Kunming inbred line and on release of SIL-2R from human lymphocytes were studied. The results showed that these peptides exhibit certain immune activity.
文摘Background Hyperbaric oxygen preconditioning （HBO） is a new method of ischemia preconditioning. In this study, we examined its effects on skin flap survival and the mechanisms involved. Methods Thirty-six rats were divided into three groups： HBO preconditioning, control, and sham groups. An extended epigastric adipocutaneous flap based on the right superficial epigastric artery and vein was raised. A 3-hour period of flap ischemia was induced by clamping the pedicle vessels with a microvascular clamp. At the end of ischemia induction, the clamp was removed and the flap was resutured. Rats in the HBO preconditioning group were treated with HBO four times before surgery. Microcirculation in the skin flap was measured on postoperative days 1, 3 and 5. The size of the flap was measured on postoperative day 5, before the animals were sacrificed. Samples of the skin flap were prepared and stained with hematoxylin and eosin. The levels of tumor necrosis factor （TNF）-α, interleukin （IL）-1β, and IL-6 in the flap samples were measured.
文摘To the editor： The diagnosis of juvenile dermatomyositis （JDM） is much more challenging when lacking the cutaneous naanifestations as well as muscular biomarkers. Here we report an interesting case of J DM.
文摘Chinese arthroplasty has made great progresses since the 1970 s, treating almost all the diarthrosis from hip to knee, shoulder, elbow, ankle and interphalangeal joints. Hip and knee, among them, are the most representative ones.
文摘The Freeman-Sheldon syndrome （FSS） is a rare congenital syndrome,characterized with myopathy and dysplasia.The musculoskeletal and soft-tissue manifestations often require orthopedic and plastic surgery.We reported a case of 8-year-old girl with FSS operated on for scoliosis.
文摘To the editor： Merkel cell carcinoma （MCC） is an extremely rare primary neuroendocrine neoplasm of the skin. It occurs more frequently in elderly and immunosuppresed individuals with a male predominance,l Merkel cell polyomavirus （MCPyV） has been recently associated with MCC, which was described as one of 7 known human oncogenic viruses.2 MCC is characterized by early and rapid metastases, although there are some reported cases with spontaneous regression.3 Mobs micrographic surgery should be considered fbr treatment of MCC. However, successful treatment still lies in diagnosis and therapy at the early stage of disease, consisting of regular dermatological checkups in older immunocompromised individuals, and early initiation of combination therapy including radical surgical treatment, radiotherapy, and chemotherapy.
