Prestress enables the Glulam beam could make full use of the compression strength,and then increase the span,but it still could not reduce all drawbacks,such as cross-section weakening and small force arm.To avoid slo...Prestress enables the Glulam beam could make full use of the compression strength,and then increase the span,but it still could not reduce all drawbacks,such as cross-section weakening and small force arm.To avoid slotting and ensure suitable tension and compression couple,one kind of novel anchor has been proposed,which could meet the bearing capacity requirement.And then the bending test of prestressed Glulam beams with a geometric scale ratio of 1:2 was simulated,to investigate the effect of the force arm on bending capacities,failure modes,and deformation performance.Results show that increasing the force arm could improve the ultimate bending per-formance of the beam significantly,and the anchor arm length has a certain effect on the performance,but it is not obvious.Finally,based on Finite element method analysis,the practice design suggestions have been offered.展开更多
Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers....Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside（present in H.rhamnoides）,zeaxanthin,and translutein（present in H.salicifolia） significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski＇s rule.Absorption,distribution,metabolism,excretion and toxicity（ADME/tox） analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers.展开更多
基金supported by the Resources Industry Science and Technology Innovation Joint Funding Project of Nanping(N2021Z003)the Special Project of Service Industry Research of Wuyi University under Grant(2021XJFWCY03)+2 种基金the Research Launch Fund of Wuyi University’s Introduct Talent(YJ202309)the Fujian Training Program of Innovation and Entrepreneurship for Undergraduates(S202210397076)Research on the Stress Performance of Reinforced Bamboo Highway Guardrail with Embedded Channel Steel(LS202304).
文摘Prestress enables the Glulam beam could make full use of the compression strength,and then increase the span,but it still could not reduce all drawbacks,such as cross-section weakening and small force arm.To avoid slotting and ensure suitable tension and compression couple,one kind of novel anchor has been proposed,which could meet the bearing capacity requirement.And then the bending test of prestressed Glulam beams with a geometric scale ratio of 1:2 was simulated,to investigate the effect of the force arm on bending capacities,failure modes,and deformation performance.Results show that increasing the force arm could improve the ultimate bending per-formance of the beam significantly,and the anchor arm length has a certain effect on the performance,but it is not obvious.Finally,based on Finite element method analysis,the practice design suggestions have been offered.
文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside（present in H.rhamnoides）,zeaxanthin,and translutein（present in H.salicifolia） significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski＇s rule.Absorption,distribution,metabolism,excretion and toxicity（ADME/tox） analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers.
