Objectives: The aim of this review is to explain the role of Dental Pulp Stem Cells (DPSCs) in repairing or regenerating damaged tissue/organs for both systemic and oral diseases and, in addition, review the different...Objectives: The aim of this review is to explain the role of Dental Pulp Stem Cells (DPSCs) in repairing or regenerating damaged tissue/organs for both systemic and oral diseases and, in addition, review the differentiation, isolation of dental pulp stem cells and their applications in regenerative medicine. Materials and Methods: An electronic search was done using Cohchrane, PubMed and Google Scholar. Out of 310 articles, only 25 articles have been selected to be included in this review because it is directly related to the topic and they are matching the inclusion criteria of this review: “Language: English” and “Year: 2006-2016”. Results: DPSCs have been widely used as a mesenchymal stem cells source due to easy accessibility and less invasive harvesting. DPSCs could be used for pulpal regeneration, tooth reconstruction, endocrinology, neurology, angiogenesis and vasculogenises. The most common application of DPSCs in the dental field is pulp regeneration. Conclusion: Stem cell-based therapy holds a great promise to solve health problems from both systemic and oral diseases. Studying in DPSCs grows rapidly;however, there are still questionable issues needed to be optimized and answered such as the variable biological capacity of DPSCs.展开更多
BACKGROUND Herpes simplex virus(HSV)is a highly infectious pathogen that is easily transmitted via the bodily fluids of an infected individual.This virus usually affects individuals older than six months of age,and ra...BACKGROUND Herpes simplex virus(HSV)is a highly infectious pathogen that is easily transmitted via the bodily fluids of an infected individual.This virus usually affects individuals older than six months of age,and rarely causes lesions or symptoms in younger patients.CASE SUMMARY We present the case of a five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles.We discuss the pathophysiology of primary HSV infection and the effect of maternal antibodies on the infant’s immune system.In addition,we explain the diagnosis,management,and prognosis of HSV infection in young infants.CONCLUSION This case highlights the importance of early diagnosis and management of HSV infections to decrease the risk of developing severe complications and death.展开更多
文摘Objectives: The aim of this review is to explain the role of Dental Pulp Stem Cells (DPSCs) in repairing or regenerating damaged tissue/organs for both systemic and oral diseases and, in addition, review the differentiation, isolation of dental pulp stem cells and their applications in regenerative medicine. Materials and Methods: An electronic search was done using Cohchrane, PubMed and Google Scholar. Out of 310 articles, only 25 articles have been selected to be included in this review because it is directly related to the topic and they are matching the inclusion criteria of this review: “Language: English” and “Year: 2006-2016”. Results: DPSCs have been widely used as a mesenchymal stem cells source due to easy accessibility and less invasive harvesting. DPSCs could be used for pulpal regeneration, tooth reconstruction, endocrinology, neurology, angiogenesis and vasculogenises. The most common application of DPSCs in the dental field is pulp regeneration. Conclusion: Stem cell-based therapy holds a great promise to solve health problems from both systemic and oral diseases. Studying in DPSCs grows rapidly;however, there are still questionable issues needed to be optimized and answered such as the variable biological capacity of DPSCs.
基金Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program.
文摘BACKGROUND Herpes simplex virus(HSV)is a highly infectious pathogen that is easily transmitted via the bodily fluids of an infected individual.This virus usually affects individuals older than six months of age,and rarely causes lesions or symptoms in younger patients.CASE SUMMARY We present the case of a five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles.We discuss the pathophysiology of primary HSV infection and the effect of maternal antibodies on the infant’s immune system.In addition,we explain the diagnosis,management,and prognosis of HSV infection in young infants.CONCLUSION This case highlights the importance of early diagnosis and management of HSV infections to decrease the risk of developing severe complications and death.
