Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

Association between Meeting 24-Hour Movement Guidelines and Psychological Features of Chinese Emerging Adults

Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated these changes with an unhealthy lifestyle.The 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual wellness.However,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be explored.This cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging adults.Methods:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this study.Each participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging adulthood.Multivariable logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four characteristics.Results:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)guidelines.Further,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.01),only sleep(β=0.61,95%CI:[0.01,1.21],p=0.04),physical activity+sedentary behavior(β=0.56,95%CI:[0.04,1.07),p=0.01),and physical activity+sleep(β=0.76,95%CI:[0.23,1.27],p=0.01).Conclusions:These findings suggest that adherence to the 24-h movement guidelines was associated with instability in Chinese emerging adults.Future studies are warranted to verify our findings to highlight the importance of maintaining a heath lifestyle to promote health in emerging adulthood.

沙库巴曲缬沙坦钠联合左西孟旦治疗射血分数降低型心力衰竭有效性和安全性的Meta分析

目的:系统评价沙库巴曲缬沙坦钠联合左西孟旦治疗射血分数降低型心力衰竭(heart failure with reduced ejection fraction,HFrEF)的有效性与安全性。方法:计算机检索PubMed、The Cochrane Library、Embase、Web of science、中国生物医学文献服务系统、中国学术期刊全文数据库、维普中文科技期刊数据库和万方数据库。搜索沙库巴曲缬沙坦钠联合左西孟旦治疗HFrEF的相关随机对照试验,检索时限为建库至2023年12月。由两位研究者独自筛选文献、提取相关有效信息和纳入评价研究的偏移风险后,使用RevMan5.4.1分析工具进行Meta分析。结果:纳入12个研究,共计1234例患者。Meta分析结果显示:沙库巴曲缬沙坦钠联合左西孟旦组的NYHA心功能改善总有效率高于对照组(RR=4.46,95%CI:2.86~6.94,P<0.00001),LVEF高于对照组(MD=6.09,95%CI:5.57,6.60,P<0.00001),LVEDD低于对照组(MD=-3.90,95%CI:-4,75~3.06,P<0.00001),不良反应低于对照组(RR=0.39,95%CI:0.21~0.72,P=0.0.003)。结论:当前证据显示,沙库巴曲缬沙坦钠联合左西孟旦能改善NYHA心功能分级,提高射血分数及抑制心室重构,而未出现明显不良反应。

Enhancing Geological Understanding and Identifying Gold Anomalies in the Ailaoshan Orogen

The Ailaoshan Orogen in the southeastern Tibet Plateau,situated between the Yangtze and Simao blocks,underwent a complex structural,magmatic,and metamorphic evolution resulting in different tectonic subzones with varying structural lineaments and elemental concentrations.These elements can conceal or reduce anomalies due to the mutual effect between different anomaly areas.Dividing the whole zone into subzones based on tectonic settings,ore cluster areas,or sample catchment basins(Scb),geochemical and structural anomalies associated with gold(Au)mineralization have been identified utilizing mean plus twice standard deviations(Mean+2STD),factor analysis(FA),concentration-area(CA)modeling of stream sediment geochemical data,and lineament density in both the Ailaoshan Orogen and the individual subzones.The FA in the divided 98 Scbs with 6 Scbs containing Au deposits can roughly ascertain unknown rock types,identify specific element associations of known rocks and discern the porphyry or skarn-type Au mineralization.Compared with methods of Mean+2STD and C-A model of data in the whole orogen,which mistake the anomalies as background or act the background as anomalies,the combined methods of FA and C-A in the separate subzones or Scbs works well in regional metallogenic potential analysis.Mapping of lineament densities with a 10-km circle diameter is not suitable to locate Au deposits because of the delineated large areas of medium-high lineament density.In contrast,the use of circle diameters of 1.3 km or 1.7 km in the ore cluster scale delineates areas with a higher concentration of lineament density,consistent with the locations of known Au deposits.By analyzing the map of faults and Au anomalies,two potential prospecting targets,Scbs 1 and 63 with a sandstone as a potential host rock for Au,have been identified in the Ailaoshan Orogen.The use of combined methods in the divided subzones proved to be more effective in improving geological understanding and identifying mineralization anomalies associated with Au,rather than analyzing the entire large area.

Core–Shell Microfiber Encapsulation Enables Glycerol‑Free Cryopreservation of RBCs with High Hematocrit

Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in emergencies.High concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinical practice,which results in cytotoxicity and osmotic injuries that must be carefully controlled.However,existing studies on the low-glycerol cryopreservation of RBCs still suffer from the bottleneck of low hematocrit levels,which require relatively large storage space and an extra concentration process before transfusion,making it inconvenient(time-consuming,and also may cause injury and sample lose)for clinical applications.To this end,we develop a novel method for the glycerol-free cryopreservation of human RBCs with a high final hematocrit by using trehalose as the sole cryoprotectant to dehydrate RBCs and using core–shell alginate hydrogel microfibers to enhance heat transfer during cryopreservation.Different from previous studies,we achieve the cryopreservation of human RBCs at high hematocrit(>40%)with high recovery(up to 95%).Additionally,the washed RBCs post-cryopreserved are proved to maintain their morphology,mechanics,and functional properties.This may provide a nontoxic,high-efficiency,and glycerol-free approach for RBC cryopreservation,along with potential clinical transfusion benefits.

Transfer force perception skills to robot‐assisted laminectomy via imitation learning from human demonstrations

A comparative study of two force perception skill learning approaches for robot‐assisted spinal surgery,the impedance model method and the imitation learning(IL)method,is presented.The impedance model method develops separate models for the surgeon and patient,incorporating spring‐damper and bone‐grinding models.Expert surgeons'feature parameters are collected and mapped using support vector regression and image navi-gation techniques.The imitation learning approach utilises long short‐term memory networks(LSTM)and addresses accurate data labelling challenges with custom models.Experimental results demonstrate skill recognition rates of 63.61%-74.62%for the impedance model approach,relying on manual feature extraction.Conversely,the imitation learning approach achieves a force perception recognition rate of 91.06%,outperforming the impedance model on curved bone surfaces.The findings demonstrate the potential of imitation learning to enhance skill acquisition in robot‐assisted spinal surgery by eliminating the laborious process of manual feature extraction.

Genomic characterization of peritoneal lavage cytology-positive gastric cancer

Objective: Positive peritoneal lavege cytology(CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric cancer.Methods: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31matched cytology-negative gastric cancer patients were enrolled in this study. The enrollment criteria were based on the results of diagnostic laparoscopy staging and cytology inspection of exfoliated cells. Whole exome sequencing was then performed on tumor samples to evaluate genomic characterization of cytology-positive gastric cancer.Results: Least absolute shrinkage and selection operator(LASSO) algorithm identified 43 cytology-positive marker genes, while Mut Sig CV identified 42 cytology-positive specific driver genes. CD3G and CDKL2 were both driver and marker genes of CY1. Regarding mutational signatures, driver gene mutation and tumor subclone architecture, no significant differences were observed between CY1 and negative peritoneal lavege cytology(CY0).Conclusions: There might not be distinct differences between CY1 and CY0, and CY1 might represent the progression of CY0 gastric cancer rather than constituting an independent subtype. This genomic analysis will thus provide key molecular insights into CY1, which may have a direct effect on treatment recommendations for CY1and CY0 patients, and provides opportunities for genome-guided clinical trials and drug development.

Experimental constraints on the formation of oxychlorine species by UV irradiation and mechanical pulverization on the lunar surface

Perchlorate and chlorate are present in various extraterrestrial celestial bodies throughout the solar system,such as Mars,the moon,and asteroids.To date,the origin mechanisms of perchlorate and chlorate on the Martian surface have been well-established;however,relatively little attention has been cast to airless bodies.Here,we experimentally investigated the potential oxidation mechanisms of chloride to chlorate and perchlorate,such as ultraviolet irradiation under H_(2)O-and O_(2)-free conditions and mechanical pulverization processes.Individual minerals,olivine,pyroxene,ilmenite,magnetite,TiO_(2)and anhydrous ferric sulfate,and lunar regolith simulants(low Ti,CLRS-1;high-Ti,CLRS-2)and their metallic iron(Fe^( 0))bearing counterparts were examined.We found that pulverization of dry matrix material-halite mixtures,even in the presence of O_(2),does not necessarily lead to perchlorate and chlorate formation without involving water.Under photocatalytic and H_(2)O and O_(2)-free conditions,olivine and pyroxene can produce oxychlorine(ClO_(x)^(−))species,although the yields were orders of magnitude lower than those under Martian-relevant conditions.Nanophase-Fe^(0)particles in the lunar regolith and the common photocatalyst TiO_(2)can facilitate the ClO_(x)^(−)formation,but their yields were lower than those with olivine.The oxides ilmenite and magnetite did not efficiently contribute to ClO_(x)^(−)production.Our results highlight the critical role of H_(2)O in the oxidation chloride to chlorate and perchlorate,and provide essential insights into the environmental influence on the formation of oxychlorine species on different celestial bodies.

招平断裂带大尹格庄矿区三维地质结构及断裂控矿规律

本文基于大尹格庄矿区264个钻孔资料,建立了矿区三维精细化地质模型,剖析了金矿床三维空间结构,指出了沿断裂构造深部找矿重点地段。三维可视化展现研究区浅部较为零散的矿体在深部连为一体,构成资源量超过200 t的超大型金矿床。对主要矿体开展品位、厚度及断裂构造形态变化的耦合关系表明,矿体存在沿走向、倾向等间距分布、侧伏和斜列分布规律,矿体富集区主要位于断裂沿倾向陡缓交替地段,进一步理清了断裂与金矿的耦合关系,显示了三维模型在深部找矿中的预测作用。

A glycine-rich nuclear effector VdCE51 of Verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhTRXH2

Verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash crops.Effectors of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,VdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia sclerotiorum.This effector was a required factor for full virulence of V.dahliae,and its nuclear localization was a requisite for suppressing plant immunity.The thioredoxin GhTRXH2,identified as a positive regulator of plant immunity,was a host target of VdCE51.Our findings show a virulence regulating mechanism whereby the secreted nuclear effector VdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhTRXH2,thus suppressing plant immunity.

Characteristics of PM_(2.5) pollution in Beijing after the improvement of air quality

Following the implementation of the strictest clean air policies to date in Beijing,the physicochemical characteristics and sources of PM_(2.5) have changed over the past few years.To improve pollution reduction policies and subsequent air quality further,it is necessary to explore the changes in PM_(2.5) over time.In this study,over one year(2017-2018)field study based on filter sampling(TH-150C;Wuhan Tianhong,China)was conducted in Fengtai District,Beijing,revealed that the annual average PM_(2.5) concentration(64.8±43.1μg/m^3)was significantly lower than in previous years and the highest PM_(2.5) concentration occurred in spring(84.4±59.9μg/m^3).Secondary nitrate was the largest source and accounted for 25.7%of the measured PM_(2.5).Vehicular emission,the second largest source(17.6%),deserves more attention when considering the increase in the number of motor vehicles and its contribution to gaseous pollutants.In addition,the contribution from coal combustion to PM_(2.5) decreased significantly.During weekends,the contribution from EC and NO3−increased whereas the contributions from SO4^2−,OM,and trace elements decreased,compared with weekdays.During the period of residential heating,PM_(2.5) mass decreased by 23.1%,compared with non-heating period,while the contributions from coal combustion and vehicular emission,and related species increased.With the aggravation of pollution,the contribution of vehicular emission and secondary sulfate increased and then decreased,while the contribution of NO3−and secondary nitrate continued to increase,and accounted for 34.0%and 57.5%of the PM_(2.5) during the heavily polluted days,respectively.

聚醚醚酮棒与钛棒在后路腰椎椎间融合中的有限元分析

背景:聚醚醚酮棒是一种新型的半刚性固定材料,但是其在后路腰椎椎间融合术中的生物力学性能仍不清楚。目的:对比聚醚醚酮棒与钛棒在后路腰椎椎间融合过程中的生物力学性能,尝试回答聚醚醚酮棒是否有潜力成为钛棒的替代品,尤其在前柱支撑不充分的情况下。方法:利用有限元方法构建完整的人腰椎(L)模型,并进一步构建4个后路腰椎椎间融合模型:①聚醚醚酮棒+cage;②钛棒+cage;③聚醚醚酮棒+纯植骨;④钛棒+纯植骨。比较不同模型中节段活动度、相关结构应力以及应变。结果与结论:①所有手术模型在限制L节段活动度方面无明显差异;②与钛棒相比,聚醚醚酮棒增加了椎间植骨的平均应变、增加了终板以及cage的峰值应力,同时降低了螺钉以及骨-螺钉界面的峰值应力;聚醚醚酮棒的峰值应力与屈服应力之比为6%-26%,高于钛棒的3%-12%;③在L节段上,聚醚醚酮棒仅轻微地降低了节段活动度与椎间盘峰值应力;④因此与钛棒相比,聚醚醚酮棒可能降低假关节、螺钉断裂与松动的风险,但是也可能导致终板塌陷、cage损坏以及棒断裂的风险更高;聚醚醚酮棒在延缓邻近节段退变中可能较钛棒有微弱的优势;在不使用cage而仅采用骨移植物进行椎间融合时,聚醚醚酮棒也许是一个可供选择的方案。

冷轧汽车板短线缺陷的分析和控制

根据冷轧连退反馈的短线缺陷(宽度0.2~0.5 mm、长度1.5~2 mm),采用扫描电镜(SEM)和电子能谱(EDS)仪分析了缺陷区域底层的物质构成,确定缺陷处的主要成分为w(Ni)=5%~7%、w(Cr)=1%~2%、w(Si)=1%~2%,与热轧精轧F4—F6无限冷硬精轧轧辊成分相同。结合缺陷的宏观特征,确定缺陷的产生机理为热轧F5—F6工作辊冷却不足,导致轧辊温度偏高,轧辊表层组织破碎剥落,压入带钢后经冷轧形成短线缺陷。通过热轧烫辊制度优化、末道次精轧负荷控制、各机架工作辊冷却水和润滑控制、F1—F6全机架高速钢轧辊配置等措施,使冷轧短线缺陷发生率由15.8%降低至1.0%。

新时代背景下三线精神与高校教师职业发展融合探究

新时代背景下,三线精神与高校教师职业发展的融合是缅怀峥嵘岁月的历史功绩,帮助高校教师树立正确的职业观念、艰苦奋斗的良好品质以及勇于创新、团结协作的精神的有效方式,同时也可以提升高校教师专业素养以及教学能力,推动高校各项工作的有序开展。然而由于部分高校领导与教师对三线精神的理解以及重视程度不足,在教师评价以及职称评定体系建设过程中,对三线精神的运用有限,阻碍了高校教师的成长发展。因此,高校需要进一步提升本校教师对三线精神的理解与重视程度,提升三线精神在高校职业目标制定上的影响力,促进高校教师职业素养的提升,实现全面发展。

存内计算芯片研究进展及应用

随着数据快速增长,冯诺依曼架构内存墙成为计算性能进一步提升的关键瓶颈。新型存算一体架构(包括存内计算(IMC)架构与近存计算(NMC)架构),有望打破冯诺依曼架构瓶颈,大幅提高算力和能效。该文介绍了存算一体芯片的发展历程、研究现状以及基于各类存储器介质(如传统存储器DRAM,SRAM和Flash和新型非易失性存储器ReRAM,PCM,MRAM,FeFET等)的存内计算基本原理、优势与面临的问题。然后,以知存科技WTM2101量产芯片为例,重点介绍了存算一体芯片的电路结构与应用现状。最后,分析了存算一体芯片未来的发展前景与面临的挑战。

Data-Driven Control of Distributed Event-Triggered Network Systems

The present paper deals with data-driven event-triggered control of a class of unknown discrete-time interconnected systems(a.k.a.network systems).To this end,we start by putting forth a novel distributed event-triggering transmission strategy based on periodic sampling,under which a model-based stability criterion for the closed-loop network system is derived,by leveraging a discrete-time looped-functional approach.Marrying the model-based criterion with a data-driven system representation recently developed in the literature,a purely data-driven stability criterion expressed in the form of linear matrix inequalities(LMIs)is established.Meanwhile,the data-driven stability criterion suggests a means for co-designing the event-triggering coefficient matrix and the feedback control gain matrix using only some offline collected state-input data.Finally,numerical results corroborate the efficacy of the proposed distributed data-driven event-triggered network system(ETS)in cutting off data transmissions and the co-design procedure.

新型活性复合射流成型及侵彻混凝土研究

为了兼顾活性复合射流对目标的侵爆联合毁伤效应,提出了一种新型活性复合药型罩聚能装药结构.采用正交设计方法,基于Autodyn-2D数值模拟平台对新型活性复合罩聚能装药结构进行了优化设计,获得了复合罩总壁厚、内罩口径比、内罩壁厚比、复合罩锥角及炸高对新结构聚能装药作用混凝土的侵彻深度、开孔直径、活性材料流入量与平均流入深度的影响规律,优化出了一组新型活性复合罩结构,并开展了新结构聚能装药作用混凝土靶的静爆实验,实验结果与仿真计算的侵深基本吻合.此外,实验结果还表明:在这种新结构活性复合射流侵爆联合作用下,可使混凝土表面形成较大崩落区,且形成的入孔孔径与仿真结果相比明显较大,这些现象表明活性材料发生了剧烈爆燃效应,可造成二次扩孔效应.

Life cycle assessment of high concentration organic wastewater treatment by catalytic wet air oxidation

There have been many studies on life cycle assessment in sewage treatment,but there are scarce few studies on the treatment of industrial wastewater in combination with advanced oxidation technology,especially in catalytic wet air oxidation(CWAO).There are no cases of using actual industrialized data onto life cycle assessment.This paper uses Simapro 9.0 software to establish a life cycle assessment model for the treatment of high-concentration organic wastewater by CWAO,and comprehensively explains the impact on the environment from three aspects:the construction phase,the operation phase and the demolition phase.In addition,sensitivity analysis and uncertainty analysis were performed.The results showed that the key factors affecting the environment were marine ecotoxicity,mineral resource consumption and global warming,the operation stage had the greatest impact on the environment,which was related to high power consumption during operation and emissions from the treatment process.Sensitivity analysis showed that electricity consumption has the greatest impact on abiotic depletion and freshwater aquatic ecotoxicity,and it also proved that global warming is mainly caused by pollutant emissions during operation phase.Monte Carlo simulations found slightly higher uncertainty for abiotic depletion and toxicity-related impact categories.

新课标视角下的语文作文教学刍论

新课标强调教师应加大教学活动中对学生核心素养的培养力度。教师在进行语文作文教学的过程中,应明确新课标中关于学生语文核心素养培养的政策要求,并在此基础上进行相应的教学设计,以构建良好的语文作文教学氛围,进一步激发学生的写作兴趣,提升学生的写作水平。文章从新课标视域下语文作文教学的价值和功能入手,分析了传统教学方式下语文作文教学中存在的问题,并对新课标视角下语文作文教学的实施策略进行探究,以期提高语文作文教学质量。

尾矿库尾矿矿物特征及综合利用探究

我国矿产资源丰富,随着经济的发展,对矿产资源的需求也在不断增加,使矿物开采严重。为了满足社会发展需求,就要利用尾矿库中的尾矿进行综合选矿,解决矿产资源不足现象。所以就要对尾矿库尾矿中的矿物特征进行分析,分别是粒度小,矿物组成复杂;富集有毒元素,缺乏经济价值;结构松散,酸性强;易流失,长期存储隐患较大等特征,并提出了其利用的方向,是在玻璃、建筑材料、填充等方面使用尾矿的矿物,提升矿产企业的资源利用效率。