A third pyrimidine strand can bind the complementary purine strand of homopurinehomopyrimidine tracts of duplex DNA to form a local triplex structure. Recently investigations have indicated that triplex-forming-oligon...A third pyrimidine strand can bind the complementary purine strand of homopurinehomopyrimidine tracts of duplex DNA to form a local triplex structure. Recently investigations have indicated that triplex-forming-oligonucleotides can specifically inhibit gene transcription in vitro and in vivo, and can be used in chromosome analysis and展开更多
基金the Eighth Five-Year Project Grant of Chinese Academy of Sciences and Natural Science Foundation of China.
文摘A third pyrimidine strand can bind the complementary purine strand of homopurinehomopyrimidine tracts of duplex DNA to form a local triplex structure. Recently investigations have indicated that triplex-forming-oligonucleotides can specifically inhibit gene transcription in vitro and in vivo, and can be used in chromosome analysis and
